ARHGAP4A
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
---|---|---|---|---|---|---|
Zebrafish | ARHGAP4A-10750Z | Recombinant Zebrafish ARHGAP4A | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
ARHGAP4A involved in several pathways and played different roles in them. We selected most pathways ARHGAP4A participated on our site, such as Cell death signalling via NRAGE, NRIF and NADE, G alpha (12/13) signalling events, GPCR downstream signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARHGAP4A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
---|---|
Cell death signalling via NRAGE, NRIF and NADE | OBSCN;AATF;NET1;ARHGEF18A;AKAP13;BCL2L11;PLEKHG2;ARHGEF3;ARHGAP4A |
G alpha (12/13) signalling events | ARHGEF3;ARHGEF16;TRIO;AKAP13;ITSN1;RHOAE;ARHGAP4;ARHGEF1B;ADRA1D |
GPCR downstream signaling | APLNR;ARHGEF17;GPR132B;TAS2R3;ARHGEF1A;RGS6;FPR-RS3;PIK3R6;RGS18 |
NRAGE signals death through JNK | FGD2;AATF;ARHGEF18A;ARHGEF18;NET1;ARHGEF1A;FGD4;FGD4A;ARHGEF16 |
Rho GTPase cycle | ARAP1;ARHGAP11A;TAGAPB;ARHGAP40;ARHGAP20;TAGAP;ARHGAP4A;MYO9B;TAGAPA |
Signal Transduction | PDK3B;BCO2;GPR68;OMG;LRP12;VIP;RSPO2;TAX1BP3;RHOT1 |
Signaling by GPCR | OR4D2;TAS2R13;EDNRAB;OR10A5;DCLRE1B;GPR4;CCL35.2;TRH;SCT |
Signaling by Rho GTPases | ARHGAP28;ARHGAP33;ARHGEF17;ARHGEF16;PLEKHG2;FMNL1;ARHGAP1;RHOT1A;ARHGAP17 |
ARHGAP4A has several biochemical functions, for example, GTPase activator activity, Rac GTPase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ARHGAP4A itself. We selected most functions ARHGAP4A had, and list some proteins which have the same functions with ARHGAP4A. You can find most of the proteins on our site.
Function | Related Protein |
---|---|
GTPase activator activity | AGFG1;LLGL1;RASAL1;SMAP1;RGS5A;SRGAP2A;TBC1D19;PLEKHG6;ALS2CL |
Rac GTPase binding | FMNL1;NCF2;RALBP1;MAP3K11;ARHGAP4A;PAK7;CDKL5;EPS8;NOXA1 |
ARHGAP4A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARHGAP4A here. Most of them are supplied by our site. Hope this information will be useful for your research of ARHGAP4A.
- Q&As
- Reviews
Q&As (16)
Ask a questionThere is limited information available on mutations or genetic variants specifically in the ARHGAP4A gene. However, the ARHGAP4 gene, which is highly similar to ARHGAP4A, has been associated with certain diseases. For example, mutations in the ARHGAP4 gene have been reported in patients with intellectual disability, epileptic encephalopathy, and developmental delay. It is possible that similar mutations or genetic variants in ARHGAP4A could also contribute to disease phenotypes, but further research is needed to explore this.
Targeting ARHGAP4A for therapeutic interventions is a possibility, as it plays a role in cellular processes that are dysregulated in certain diseases. However, more research is needed to fully understand the function and regulation of ARHGAP4A, as well as its specific roles in disease pathogenesis. Additionally, developing targeted therapies that selectively modulate the activity of ARHGAP4A without affecting other essential cellular functions may pose a challenge. Nevertheless, exploring the therapeutic potential of ARHGAP4A is an area of interest for future research.
Although ARHGAP4A has not been extensively studied in the context of cancer, Rho GTPase signaling pathways have been implicated in tumorigenesis and metastasis. Hence, targeting ARHGAP4A or other molecules involved in Rho GTPase regulation could hold potential as a therapeutic approach for certain cancers. Further research is needed to establish its therapeutic relevance in specific cancer types.
The involvement of ARHGAP4A in neurological disorders has not been extensively studied. However, since Rho GTPases and their regulators play crucial roles in neuronal development, axon guidance, and synaptic plasticity, it is possible that dysregulation of ARHGAP4A could contribute to neurological disorders. Further research is needed to explore its potential role in these disorders.
Currently, there is limited information linking ARHGAP4A to specific diseases. However, dysregulation of Rho GTPase signaling pathways, which may involve ARHGAP4A, has been implicated in diseases such as cancer, cardiovascular disorders, and neurological disorders.
The involvement of ARHGAP4A in cell division or cell cycle regulation is not well studied. However, since Rho GTPase signaling is known to play a role in these processes, it is possible that ARHGAP4A, as a regulator of Rho GTPase activity, might influence cell division and cell cycle progression indirectly. Future research is needed to explore this potential connection and elucidate the specific mechanisms by which ARHGAP4A might impact cell division and the cell cycle.
Yes, ARHGAP4A can interact with various proteins to regulate Rho GTPase signaling and other cellular processes. For example, it has been shown to interact with Rho family GTPases (such as RhoA and CDC42) through its RhoGAP domain, promoting their inactivation. ARHGAP4A can also interact with other proteins involved in cytoskeletal organization and cell migration, such as α-actinin and filamin. These protein-protein interactions play a role in the modulation of cellular functions.
Research on ARHGAP4A is ongoing, with scientists investigating its role in various cellular processes and its potential involvement in disease pathways. Further studies are needed to fully understand the functional significance of ARHGAP4A and its potential as a therapeutic target.
The precise role of ARHGAP4A in disease pathogenesis is not well established. However, dysregulation of Rho GTPase signaling, to which ARHGAP4A contributes, has been implicated in various diseases. For example, aberrant Rho GTPase activity has been associated with cancer metastasis, cardiovascular disease, neurological disorders, and immune system dysfunctions. Further research is needed to determine the specific contribution of ARHGAP4A to these disease processes.
The involvement of ARHGAP4A in neuronal development has not been extensively studied. However, considering the role of Rho GTPases in neuronal processes such as neurite outgrowth and growth cone dynamics, it is plausible that ARHGAP4A may have a role in neuronal development and synaptic plasticity.
ARHGAP4A regulates cell migration by modulating Rho GTPase activity and cytoskeletal dynamics. Its RhoGAP domain promotes the inactivation of Rho family GTPases, leading to the disassembly of actin stress fibers and focal adhesions, which are necessary for cell migration. By inhibiting Rho GTPase signaling, ARHGAP4A can regulate the formation of lamellipodia and filopodia, which are crucial for cell motility.
At present, there are no known animal models specifically targeting ARHGAP4A. However, general Rho GTPase-deficient animal models, or models focusing on related ARHGAP family members, can provide insights into the functions and potential involvement of ARHGAP4A in various biological processes.
ARHGAP4A is involved in various cellular processes, including cell migration, cell adhesion, cytoskeletal organization, and signaling pathways mediated by Rho GTPases. By regulating Rho GTPase activity, ARHGAP4A impacts actin cytoskeleton dynamics, focal adhesion formation, lamellipodia and filopodia formation, and overall cell motility. Additionally, ARHGAP4A's interaction with other proteins can influence cellular processes related to membrane dynamics and protein-protein interactions.
Given its role in regulating RhoA and potentially other Rho GTPases, ARHGAP4A holds promise as a potential therapeutic target. However, more studies are required to better understand its specific functions and potential implications for disease treatments.
Specific natural inhibitors or activators of ARHGAP4A have not been reported so far. However, some signaling pathways or extracellular cues have been shown to regulate the activity of Rho GTPases, which indirectly influence ARHGAP4A function. Identifying specific modulators of ARHGAP4A would require further research.
ARHGAP4A has been reported to interact with several other proteins, including guanine nucleotide exchange factors (GEFs) that activate Rho GTPases and other RhoGAPs that regulate the activity of Rho GTPases. These interactions contribute to the intricate regulation of Rho GTPase signaling pathways in cells.
Customer Reviews (8)
Write a reviewThis can help ensure compatibility between different components used in the trials and ease the overall experimental workflow.
A manufacturer that can deliver the protein promptly and reliably can save researchers time and allow them to proceed with their experiments without unnecessary delays.
Manufacturers can support researchers in developing assays to measure ARHGAP4A protein levels or activity specific to their clinical trial settings.
They can offer detailed characterization data, including purity, stability, and functional assessments, to support researchers' confidence in using the protein in their trials.
This support could range from assisting with experimental design to offering advice on optimal protein handling and storage conditions.
A reliable manufacturer should be able to provide a consistently pure and high-quality ARHGAP4A protein, ensuring that the samples are suitable for research purposes.
This may involve guidance in selecting appropriate detection methods, providing assay components, or optimizing protocols for optimal performance and sensitivity.
Such manufacturer support fosters a conducive environment for successful and impactful research outcomes.
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