ARHGDIB
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Official Full Name
Rho GDP dissociation inhibitor (GDI) beta
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Overview
Members of the Rho (or ARH) protein family (see MIM 165390) and other Ras-related small GTP-binding proteins (see MIM;179520) are involved in diverse cellular events, including cell signaling, proliferation, cytoskeletal organization,;and secretion. The GTP-binding proteins are active only in the GTP-bound state. At least 3 classes of proteins tightly;regulate cycling between the GTP-bound and GDP-bound states: GTPase-activating proteins (GAPs), guanine;nucleotide-releasing factors (GRFs), and GDP-dissociation inhibitors (GDIs). The GDIs, including ARHGDIB, decrease the;rate of GDP dissociation from Ras-like GTPases (summary by Scherle et al., 1993 (PubMed 8356058)). -
Synonyms
ARHGDIB; Rho GDP dissociation inhibitor (GDI) beta; GDIA2, GDID4, RAP1GN1; rho GDP-dissociation inhibitor 2; Ly GDI; RhoGDI2; Rho GDI 2; rho-GDI beta; D4; GDIA2; GDID4; LYGDI; Ly-GDI; RAP1GN1;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- His|GST
- Myc
- DDK
- MYC
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
ARHGDIB involved in several pathways and played different roles in them. We selected most pathways ARHGDIB participated on our site, such as Neurotrophin signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARHGDIB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Neurotrophin signaling pathway | SH2B1;RAP1A;KRAS;MAPK1;RAPGEF1;CDC42;SHC1;NTRK2;NTF4 |
ARHGDIB has several biochemical functions, for example, GTPase activator activity, GTPase activity, Rho GDP-dissociation inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ARHGDIB itself. We selected most functions ARHGDIB had, and list some proteins which have the same functions with ARHGDIB. You can find most of the proteins on our site.
Function | Related Protein |
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GTPase activator activity | RASAL1;RABGAP1;SH3BGRL3;ARHGAP33;ASAP2;GIT2B;ECT2;RASA1;ARHGAP15 |
GTPase activity | GNGT2;RAP1GAP;RAB18A;EEF1A2;RND1;RASEF;MFN1;GNG10;TUBG1 |
Rho GDP-dissociation inhibitor activity | ARHGDIG;ARHGDIB;ARHGDIA |
ARHGDIB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARHGDIB here. Most of them are supplied by our site. Hope this information will be useful for your research of ARHGDIB.
RAC2; RAC3; UFM1; RAC1; ANKRD1; dacD; pepP; nagA; asd; 1-phosphatidyl-1d-myo-inositol 3,5-bisphosphate; 1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate
- Q&As
- Reviews
Q&As (18)
Ask a questionARHGDIB does not have known isoforms or splice variants. It is a single gene that encodes a conserved protein across different species and tissues.
ARHGDIB binds to GTP-bound Rho GTPases and inhibits their activity by preventing their dissociation from the cell membrane, thus keeping them inactive.
Mutations in the ARHGDIB gene have not been clearly associated with any genetic disorders. However, further research is needed to explore any potential disease-causing mutations in ARHGDIB.
Yes, ARHGDIB has been reported to play a role in other cellular processes, including vesicular trafficking, cell adhesion, and apoptosis.
The potential diagnostic utility of ARHGDIB expression changes is currently not well established. However, alterations in ARHGDIB expression levels have been observed in certain cancers, suggesting its potential as a diagnostic marker in those specific contexts.
Both ARHGDIA and ARHGDIB are members of the Rho GTPase regulator family and play roles in modulating Rho GTPase activity. However, they have distinct amino acid sequences and may have different tissue expression patterns and specific functions in cellular processes.
Yes, ARHGDIB can interact with various proteins involved in cell signaling pathways, particularly those associated with Rho GTPase signaling. These include guanine nucleotide exchange factors (GEFs), GTPase-activating proteins (GAPs), and effector proteins that mediate downstream signaling events.
ARHGDIB inhibits Rho GTPases, which are central regulators of cell motility. By keeping Rho GTPases inactive, ARHGDIB can suppress cell migration and invasion.
Yes, ARHGDIB can undergo post-translational modifications such as phosphorylation, acetylation, and ubiquitination, which can regulate its stability, function, and cellular localization.
Although not extensively studied, some studies have suggested a potential link between ARHGDIB dysregulation and certain diseases, including cancer, neuronal disorders, and cardiovascular diseases. However, more research is needed to establish these associations conclusively.
Although ARHGDIB has not been extensively studied in the context of diseases, alterations in its expression or function have been implicated in certain cancers, such as hepatocellular carcinoma and colorectal cancer.
Yes, knockout studies have been performed on ARHGDIB in animal models to investigate its physiological functions. These studies have provided insights into the role of ARHGDIB in various cellular processes and its impact on overall organismal development.
Yes, ARHGDIB has been implicated in various cellular processes, including cell adhesion, cytoskeleton organization, cell polarity, cell division, and vesicle trafficking.
Modulation of ARHGDIB expression or activity may have therapeutic implications in cancer treatment. Since Rho GTPase signaling is involved in cancer progression and metastasis, targeting ARHGDIB might help inhibit these processes and improve treatment outcomes.
The potential of ARHGDIB as a therapeutic target is still being explored. Modulation of ARHGDIB expression or activity could have therapeutic implications in certain diseases, particularly those involving aberrant Rho GTPase signaling. However, further studies are needed to assess the feasibility and efficacy of targeting ARHGDIB for therapeutic interventions.
Yes, ongoing research is focused on further understanding the role of ARHGDIB in cellular processes, its potential involvement in diseases, and its therapeutic implications. Researchers are also exploring the underlying molecular mechanisms of ARHGDIB regulation and its interactions with other proteins.
As of now, there is limited research on targeting ARHGDIB for therapeutic purposes. However, further investigations are needed to explore its potential as a therapeutic target in various diseases.
ARHGDIB has been reported to interact with several proteins, including Rho GTPases, specific guanine nucleotide exchange factors (GEFs), and other regulatory proteins involved in Rho GTPase signaling.
Customer Reviews (8)
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