ARMCX1
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Official Full Name
armadillo repeat containing, X-linked 1
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Overview
This gene encodes a member of the ALEX family of proteins and may play a role in tumor suppression. The encoded protein;contains a potential N-terminal transmembrane domain and two Armadillo (arm) repeats. Other proteins containing the;arm repeat are involved in development, maintenance of tissue integrity, and tumorigenesis. This gene is closely;localized with other family members, including ALEX2 and ALEX3, on the X chromosome. -
Synonyms
ARMCX1; armadillo repeat containing, X-linked 1; armadillo repeat-containing X-linked protein 1; ALEX1; ARMCX 1; AD032; ARM protein lost in epithelial cancers on chromosome X 1; Armadillo repeat containing X linked protein 1; ARMX1_HUMAN; Protein ALEX1; OTTHUMP00000023686; arm protein lost in epithelial cancers, X chromosome, 1;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Rat
- Rhesus Macaque
- E.coli
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- N/A
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | ARMCX1-9871H | Recombinant Human ARMCX1, His-tagged | E.coli | His | 28-229a.a. | |
Human | ARMCX1-833H | Recombinant Human ARMCX1 protein, GST-tagged | Wheat Germ | GST | ||
Human | ARMCX1-126HCL | Recombinant Human ARMCX1 cell lysate | N/A | |||
Human | ARMCX1-1280HF | Recombinant Full Length Human ARMCX1 Protein, GST-tagged | In Vitro Cell Free System | GST | 453 amino acids | |
Rat | ARMCX1-791R | Recombinant Rat ARMCX1 Protein | Mammalian Cell | His | ||
Rat | ARMCX1-447R-B | Recombinant Rat ARMCX1 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Rat | ARMCX1-447R | Recombinant Rat ARMCX1 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Rhesus Macaque | ARMCX1-410R | Recombinant Rhesus monkey ARMCX1 Protein, His-tagged | Mammalian Cell | His | ||
Rhesus Macaque | ARMCX1-239R | Recombinant Rhesus Macaque ARMCX1 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Rhesus Macaque | ARMCX1-239R-B | Recombinant Rhesus Macaque ARMCX1 Protein Pre-coupled Magnetic Beads | HEK293 |
- Involved Pathway
- Protein Function
- Interacting Protein
ARMCX1 involved in several pathways and played different roles in them. We selected most pathways ARMCX1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ARMCX1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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ARMCX1 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ARMCX1 itself. We selected most functions ARMCX1 had, and list some proteins which have the same functions with ARMCX1. You can find most of the proteins on our site.
Function | Related Protein |
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protein binding | STAT5B;ZNF266;ARPC5;FAM54A;FAM158A;GNB1;KIRREL3;MMP20;ASB2 |
ARMCX1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARMCX1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ARMCX1.
COIL; ZBTB8A; TFIP11; y4083_yerpe
- Q&As
- Reviews
Q&As (23)
Ask a questionThe impact of changes in ARMCX1 expression levels on cell proliferation or apoptosis is not currently clear. Further studies are needed to investigate whether alterations in ARMCX1 expression can influence these cellular processes.
There is limited information available regarding ARMCX1 gene polymorphisms and their association with disease susceptibility. More research is required to determine any potential links between ARMCX1 polymorphisms and disease susceptibility.
Yes, the ARMCX1 protein has orthologs in various species, including mammals such as mice, rats, and primates. These orthologs share high sequence similarity and are believed to have similar functions.
The expression pattern of the ARMCX1 protein across different tissues and organs varies. It is expressed in various tissues, including the brain, testes, heart, and placenta, suggesting its potential roles in multiple biological processes.
Mutations in the ARMCX1 gene can potentially lead to loss or gain of protein function. Loss-of-function mutations may result in reduced or altered ARMCX1 protein activity, while gain-of-function mutations may enhance its activity or disrupt normal cellular processes.
The involvement of the ARMCX1 protein in signaling pathways is not yet well characterized. However, studies suggest its potential interaction with other proteins involved in cellular signaling and gene expression regulation.
Mutations or genetic variations in the ARMCX1 gene have been identified in individuals with X-linked intellectual disability. These mutations are believed to disrupt normal neuronal development and synaptic function, leading to cognitive impairments.
Yes, the ARMCX1 protein contains multiple armadillo (ARM) repeat domains. Armadillo repeats are known for their protein-protein interaction properties, suggesting that ARMCX1 may interact with other proteins through these domains.
At present, there are no established biomarkers based on ARMCX1 expression levels for any diseases. However, future research may reveal potential associations with specific diseases, leading to the identification of ARMCX1 as a biomarker candidate.
There is evidence to suggest that the expression of the ARMCX1 gene is indeed tissue-specific. Studies have shown that ARMCX1 is expressed in a variety of tissues, including the brain, heart, kidney, and testis. However, the precise tissue-specific regulation of ARMCX1 expression is still not well understood.
Currently, there are no specific animal models available for studying the function of ARMCX1. The generation of animal models, such as knockout mice, could be valuable for investigating the biological role of ARMCX1 in vivo.
Yes, scientists are actively studying the ARMCX1 protein to understand its function, mechanism of action, and its association with specific genetic disorders or conditions.
Although primarily associated with X-linked intellectual disability, the ARMCX1 protein's potential involvement in other diseases or conditions is not yet well established. Further research is needed to explore its role in different biological contexts.
Currently, there are no specific drugs or treatments targeting the ARMCX1 protein. However, ongoing research may identify potential therapeutic interventions related to its functions and associated disorders in the future.
The ARMCX1 protein's role in developmental processes is not yet clearly defined. However, its expression in various organs and tissues suggests potential involvement in developmental events such as neurogenesis and organogenesis.
Currently, there are no specific drugs or therapeutics targeting the ARMCX1 protein. However, further exploration of its function and involvement in diseases may provide opportunities for the development of targeted therapies in the future.
The ARMCX1 protein is predominantly localized in the cytoplasm of cells. However, it has been reported to shuttle between the cytoplasm and the nucleus, suggesting potential nuclear functions.
Some proteins that have been reported to interact with the ARMCX1 protein include BRCA1-associated RING domain protein 1 (BARD1) and the histone deacetylase HDAC6. These interactions may contribute to the protein's functional role in cellular processes.
The ARMCX1 protein has been shown to interact with various proteins, such as transcription factors, co-factors, and components of the chromatin remodeling complex. These interactions may be crucial for its function and role in cellular processes.
The exact role of ARMCX1 in cell signaling pathways is not well understood. However, studies have suggested potential involvement of ARMCX1 in pathways such as MAPK/ERK signaling and the Wnt/β-catenin pathway. Further investigation is needed to elucidate the precise mechanisms and functions of ARMCX1 in these pathways.
Currently, the main association of ARMCX1 is with X-linked intellectual disability. There is no strong evidence implicating it in other neurological disorders. However, its potential role in other disorders or neurological conditions remains a subject of ongoing research.
Mutations in the ARMCX1 gene have been associated with X-linked intellectual disability, which is a condition characterized by developmental delays and intellectual impairments in affected individuals.
The regulation of ARMCX1 protein is not yet fully understood. However, studies suggest that its expression and activity can be regulated at the transcriptional level through various signaling pathways and transcription factors.
Customer Reviews (6)
Write a reviewthe manufacturer's dedication to excellent technical support assures me that any challenges or obstacles I encounter will be swiftly resolved.
ARMCX1 protein is highly recommended for researchers, as it demonstrates excellent performance in WB experiments and has proven useful in protein electron microscopy structure analysis.
The high-quality ARMCX1 protein available from manufacturers ensures consistent and reproducible results in WB experiments, making it an essential tool for researchers studying ANO2-related pathways and biological processes.
Its top-notch purity and integrity instill confidence in obtaining precise and reliable data, thereby enabling significant advancements in my research.
Coupled with the manufacturer's commitment to impeccable technical support, I am equipped with the necessary tools to overcome any hurdles and achieve significant breakthroughs in my scientific pursuits.
ARMCX1 protein is highly recommended for researchers due to its excellent performance in various assays, particularly in Western blotting (WB) experiments, and its applicability in protein electron microscopy structure analysis.
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