ATM
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Official Full Name
ataxia telangiectasia mutated
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Overview
The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle;checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins,;including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA;repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell;cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability.Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. -
Synonyms
ATM; ataxia telangiectasia mutated; ATA, ataxia telangiectasia mutated (includes complementation groups A, C and D) , ATC, ATD, ATDC; serine-protein kinase ATM; TEL1; telomere maintenance 1; homolog (S. cerevisiae); TELO1; AT mutated; A-T mutated; TEL1,;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- E.coli
- HEK293
- In Vitro Cell Free System
- Insect Cell
- Mammalian Cell
- Mammalian cell line
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- His|GST
- His|T7
- N
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | ATM-848H | Recombinant Human ATM | Mammalian Cell | His | ||
Human | ATM-6852H | Recombinant Human ATM protein, His & GST-tagged | E.coli | His/GST | Val2484~Arg2748 (Accession # Q13315) | |
Human | ATM-9987H | Recombinant Human ATM, GST-tagged | E.coli | GST | 1332-1479a.a. | |
Human | ATM-185H | Recombinant Human ATM protein, GST-tagged | Insect Cell | GST | ||
Human | ATM-953H | Recombinant Human ATM protein, GST-tagged | Wheat Germ | GST | ||
Human | ATM-0624H | Recombinant Human ATM Protein (Met1-Arg110), N-His-tagged | E.coli | N-His | Met1-Arg110 | |
Human | ATM-1531HF | Recombinant Full Length Human ATM Protein, GST-tagged | In Vitro Cell Free System | GST | 138 amino acids | |
Human | ATM-186H | Active Recombinant Human ATM Protein (Full Length), Flag-tagged | Mammalian cell line | Flag | ||
Human | ATM-2514H | Recombinant Human ATM Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Human | ATM-2514H-B | Recombinant Human ATM Protein Pre-coupled Magnetic Beads | HEK293 | |||
Mouse | Atm-6853M | Recombinant Mouse Atm protein, His & T7-tagged | E.coli | His/T7 | Ile486~Ser742 (Accession # Q62388) | |
Mouse | ATM-2094M | Recombinant Mouse ATM Protein | Mammalian Cell | His | ||
Mouse | ATM-834M-B | Recombinant Mouse ATM Protein Pre-coupled Magnetic Beads | HEK293 | |||
Mouse | ATM-834M | Recombinant Mouse ATM Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Chicken | ATM-3968C | Recombinant Chicken ATM | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
- ATM Related Articles
- ATM Related Signal Pathway
ATM involved in several pathways and played different roles in them. We selected most pathways ATM participated on our site, such as NF-kappa B signaling pathway, FoxO signaling pathway, Cell cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with ATM were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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NF-kappa B signaling pathway | BCL2A1;PRKCB;PLCG1;IKBKB;DDX58;CD14;TRAF2;IKBKG;IRAK1 |
FoxO signaling pathway | MAPK8A;GADD45AB;SGK2;PDPK1B;CCND2A;RAG2;MAPK11;PIK3R3;EGFRA |
Cell cycle | HJURP;CCDC99;KNTC1;YWHABA;DYNC1H1;CCNB1;PIANP;ARF1;GSK3AA |
p signaling pathway | CCNB1;SERPINE1;ATM;CCND2;MDM2;PPM1DA;CCNG2;TNFRSF10B;GADD45BA |
Apoptosis | IRF4;TNFRSF10A;BIRC7;CTNNB1;DSG3;PIK3R5;DSP;BCL2L11;BCAP31 |
HTLV-I infection | SMAD2;SFPI1;IKBKG;WNT10B;PRKACB;NRP1;SRF;HLA-DRA;SLC25A31 |
Transcriptional misregulation in cancer | RUNX1;REL;ERG;TP53;EWSR1;PBX1;NTRK1;NCOR1;PFTK1 |
MicroRNAs in cancer | DICER1;BCL2;NOTCH1;EZR;CCND1;DNMT3B;HOXD10;ROCK1;PRKCE |
ATM has several biochemical functions, for example, 1-phosphatidylinositol-3-kinase activity, ATP binding, DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ATM itself. We selected most functions ATM had, and list some proteins which have the same functions with ATM. You can find most of the proteins on our site.
Function | Related Protein |
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1-phosphatidylinositol-3-kinase activity | PIK3CA;PIK3C2A;PIK3R3;PIK3CD;PIK3C2G;ATM;PIK3CB;PIK3C3;PIK3C2B |
ATP binding | OASL;RARS;PIM2;MOS;CAMK2G;ABL2;PIP5K1B;HSPA4L;MAP2K1 |
DNA binding | PMS2;HOXA10B;ZEB1B;ZFP536;GON4L;ELF2B;ZNF484;TADA2A;PAX2A |
DNA-dependent protein kinase activity | PRKDC;ATM;XRCC6BP1;HMGA2;ALPK2 |
histone serine kinase activity | AURKB;ATM;PRKAA1;AURKC;PRKAA2;AURKA |
protein N-terminus binding | MEN1;MAP2K1;ACOX1;EIF5A;GLRX;NBN;MAU2;LACRT;SNF8 |
protein binding | HOMEZ;DAPP1;UBA2;MYZAP;NXF1;FAM189B;MB21D2;BET1;PPP2R3A |
protein complex binding | RAD18;ITPR1;WASF1;UQCRC2;SKIL;EP300;ING2;Casp3;STK11 |
protein dimerization activity | NCOA3;ATOH7;SRFA;MYC;RIMKLB;TWIST1A;TCF3B;HER1;SCXA |
protein serine/threonine kinase activity | PLK2B;RIOK3;TNNI3K;PSKH2;MYO3B;UHMK1;BMP2K;SIK3;TRIO |
ATM has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ATM here. Most of them are supplied by our site. Hope this information will be useful for your research of ATM.
TELO2; TERF1; TTI1; NABP2; ATMIN
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