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BLM

Official Full Name

Bloom syndrome, RecQ helicase-like
Overview

The Bloom syndrome gene product is related to the RecQ subset of DExH box-containing DNA helicases and has both DNA-stimulated ATPase and ATP-dependent DNA helicase activities. Mutations causing Bloom syndrome delete or alter helicase motifs and may disable the 3-5 helicase activity.The normal protein may act to suppress inappropriate recombination.
Synonyms

BLM; Bloom syndrome, RecQ helicase-like; Bloom syndrome; Bloom syndrome protein; BS; RECQ2; RECQL3; recQ protein-like 3; DNA helicase, RecQ-like type 2; RECQL2; MGC126616; MGC131618; MGC131620;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse

Source

E.coli
HEK293
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
His|Myc

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	BLM-241H	Recombinant Human BLM Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	BLM-34H	Recombinant Human BLM Protein	E.coli			Inquiry
Mouse	BLM-2415M	Recombinant Mouse BLM Protein	Mammalian Cell	His		Inquiry
Mouse	BLM-2206M	Recombinant Mouse BLM Protein (684-859 aa), His-Myc-tagged	E.coli	His/Myc	684-859 aa	Inquiry
Mouse	BLM-1040M-B	Recombinant Mouse BLM Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	BLM-1040M	Recombinant Mouse BLM Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Chicken	BLM-1738C	Recombinant Chicken BLM	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
BLM Related Articles

BLM involved in several pathways and played different roles in them. We selected most pathways BLM participated on our site, such as Homologous recombination, Fanconi anemia pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with BLM were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Homologous recombination	RAD51B;POLD2;FUZ;SHFM1;RAD54L;RPA2;CDK5R2;RPA3;RAD51C
Fanconi anemia pathway	REV1;PALB2;FANCM;RPA3;ZBTB32;POLH;HES1;BRCA2;EME1

BLM has several biochemical functions, for example, ATP binding, ATP-dependent 3-5 DNA helicase activity, ATP-dependent DNA helicase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by BLM itself. We selected most functions BLM had, and list some proteins which have the same functions with BLM. You can find most of the proteins on our site.

Function	Related Protein
ATP binding	PIK3C2G;TMEM38A;SMARCA5;TLK1A;FGFR1A;PRKCD;HIPK3A;UBE2Z;ACVR2A
ATP-dependent 3-5 DNA helicase activity	WRN;RECQL4;ASCC3;BLM
ATP-dependent DNA helicase activity	WRN;CHD2;FBXO18;RUVBL2;CHD1;G3BP1;CHST13;XRCC6;XRCC5
ATP-dependent helicase activity	CHD4A;RTEL1;SNRNP200;ERCC6L2;DHX37;RECQL5;TTF2;DHX36;BLM
ATPase activity	CARNS1;ATP13A;KIF3C;NSFB;PSMC3;ABCA1B;ATAD1B;CLPX;PSMC1
DNA binding	POU3F2B;MCM3;ZFP639;HJURP;H2AFV;KHSRP;ZNF697;SP140L;ISL2B
G-quadruplex DNA binding	WRN;BLM;LONP1;DHX36
annealing helicase activity	RECQL;SMARCAL1;RAD54L;RECQL4;BLM;ANXA1;ZRANB3
bubble DNA binding	BLM;RECQL4;ERCC5;NEIL3;WRN;HMGB1
catalytic activity	HADHAA;SLC27A1B;AZIN1B;LDHBA;TDH;CKBA;SLC3A2;DPYDB;HADHAB
four-way junction helicase activity	WRN;BLM
helicase activity	ACTG2;SUPV3L1;SETX;GTF2F2;EIF4A2;UPF1;MCM9;DHX37;RAD54L
hydrolase activity	Ctsl;PLCD3A;CDC14AB;DDX51;DCP1A;ABHD16B;CHD8;SHHB;G6PC3
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	BLM;RTEL1;CHD4A
nucleic acid binding	ZKSCAN17;RBPMS2;ZIC6;SCRT2;SP5L;EAR1;HNRNPABA;SRSF5B;BCL11AB
nucleotide binding	MSI2;RPL23A;RAF1A;ACTG2;KIF15;TUBB2;TSSK1;BMPR2A;CHD9
p53 binding	EHMT1;ZNF346;TRIAP1;ANKRD1;MAPKAPK5;TP53BP1;TAF3;BCL2L12;ZFP385C
protein binding	ATP6AP2;DUSP15;UBE2H;SOX13;TRIM6;PINX1;NTN1;ANXA2;KRT14
single-stranded DNA binding	NUP35;NABP1A;RAD51L3;FUBP1;CTC1;RPA4;RAD51B;ERCC1;RBMS1

BLM has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BLM here. Most of them are supplied by our site. Hope this information will be useful for your research of BLM.

Aono, Y; Kishi, M; et al. Role of Platelet-Derived Growth Factor/Platelet-Derived Growth Factor Receptor Axis in the Trafficking of Circulating Fibrocytes in Pulmonary Fibrosis. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY 51:793-801(2014).

Li, J; Wang, G; et al. Transforming growth factor beta regulates beta-catenin expression in lung fibroblast through NF-kappa B dependent pathway. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 34:1219-1224(2014).