BTRC
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Official Full Name
beta-transducin repeat containing E3 ubiquitin protein ligase
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Overview
beta-transducin repeat-containing protein (beta-TrCP or FBW1A) is an F-box family protein characterized by the presence of the protein-protein mediating F-box domain first described in cyclin F. F box proteins act as substrate adapters that target protein -
Synonyms
BTRC; beta-transducin repeat containing E3 ubiquitin protein ligase; beta transducin repeat containing; F-box/WD repeat-containing protein 1A; beta TrCP1; betaTrCP; bTrCP; bTrCP1; FBXW1A; Fwd1; beta-TrCP1; E3RSIkappaB; F-box and WD-repeat protein 1B; pIka;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Cynomolgus Monkey
- Human
- Mouse
- E.coli
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- BTRC Related Research Area
BTRC involved in several pathways and played different roles in them. We selected most pathways BTRC participated on our site, such as Oocyte meiosis, Ubiquitin mediated proteolysis, Wnt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with BTRC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Oocyte meiosis | IGF1R;PPP3CA;YWHAQA;ANAPC7;PPP3CC;YWHAB;MAD2L1;CCNE1;RPS6KA2 |
| Ubiquitin mediated proteolysis | RNF7;UBE2NA;UBE2E3;KEAP1;CDC23;CDC34A;CUL1;CDC34;UBE2L3B |
| Wnt signaling pathway | TCF7L2;NFATC3;WNT8A;WNT9B;CTBP2A;WIF1;WNT2;WNT2B;TBL1X |
| Hedgehog signaling pathway | WNT7AA;WNT4;BTRC;WNT11B;GAS1B;GLI3;IHHB;CSNK1DB;RAB23 |
| Hippo signaling pathway | WNT5A;AFP;WNT9B;SAV1;SMAD7;WNT11;WNT7A;ACTB;TGFBR1 |
| Circadian rhythm | FBXL3;PRKAA2;RORA;PRKAG3;CSNK1E;BTRC;PRKAG2;PRKAB1;CUL1 |
| Shigellosis | ELMO2;MAPK9;MAPK12;NFKBIA;ITGA5;CDC42;PFN2;WASF1;WASL |
BTRC has several biochemical functions, for example, beta-catenin binding, ligase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BTRC itself. We selected most functions BTRC had, and list some proteins which have the same functions with BTRC. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| beta-catenin binding | CTNNA3;ESR1;PTPRJ;TCF7L2;BCL9;TCF7;SMAD7;TCF7L1B;CDH5 |
| ligase activity | HERC3;CPS1;MID2;NEDD4;UFL1;ACSL1;TRAF2;LRSAM1;RNF126 |
| protein binding | WBP4;RFX1;RPTOR;NPM3;HSPB9;ANAPC4;GET4;TCL1A;RPL39L |
| protein dimerization activity | NEUROD6B;HER2;MESP1;POLR2C;NEUROG1;BTRC;NEUROD6A;AHRRB;FERD3L |
| protein phosphorylated amino acid binding | ARRB1;CRK;BTRC |
| ubiquitin protein ligase activity | LRSAM1;ANAPC11;C12orf51;RNF19B;MED1;RNF115;HECW1;UBE2G1;PJA1 |
| contributes_to ubiquitin-protein transferase activity | KLHL4;BACH1A;KLHL28;KEAP1;KLHDC7B;KLHL23;KBTBD12;TNFAIP1;KBTBD2 |
BTRC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BTRC here. Most of them are supplied by our site. Hope this information will be useful for your research of BTRC.
SKP1; CUL1; CTNNB1
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