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C12orf65

Official Full Name

C12orf65 chromosome 12 open reading frame 65 [ Homo sapiens (human) ]
Overview

This nuclear gene encodes a mitochondrial matrix protein that appears to contribute to peptide chain termination in the mitochondrial translation machinery. Two different 1 bp deletions (resulting in the same premature stop codon)result in decreased mitochondrial translation, decreased levels of oxidative phosphorylation complexes and encepthalomyopathy. Alternative splicing results in multiple transcript variants.
Synonyms

C12orf65; chromosome 12 open reading frame 65; CL065_HUMAN; COXPD7; mitochondrial; Probable peptide chain release factor C12orf65; probable peptide chain release factor C12orf65, mitochondrial; SPG55;

Type

Recombinant Proteins
Cell & Tissue Lysates

Species

Human

Source

E.coli
HEK293
HEK293T
In Vitro Cell Free System
Wheat Germ

Tag

GST
Myc
DDK
Myc|DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	C12orf65-10376H	Recombinant Human C12orf65, GST-tagged	E.coli	GST	11-94a.a.	$319 / 25ug
Human	C12orf65-624H	Recombinant Human C12orf65 Protein, MYC/DDK-tagged	HEK293	Myc/DDK		Inquiry
Human	C12orf65-8310HCL	Recombinant Human C12orf65 293 Cell Lysate	HEK293	N/A		Inquiry
Human	C12orf65-6454H	Recombinant Human C12orf65 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK		Inquiry
Human	C12orf65-4328H	Recombinant Human C12orf65 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	C12orf65-5061HF	Recombinant Full Length Human C12orf65 Protein, GST-tagged	In Vitro Cell Free System	GST	166 amino acids	Inquiry

Involved Pathway
Protein Function
Interacting Protein
C12orf65 Related Articles

C12orf65 involved in several pathways and played different roles in them. We selected most pathways C12orf65 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with C12orf65 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

C12orf65 has several biochemical functions, for example, aminoacyl-tRNA hydrolase activity, ribosome binding, translation release factor activity, codon nonspecific. Some of the functions are cooperated with other proteins, some of the functions could acted by C12orf65 itself. We selected most functions C12orf65 had, and list some proteins which have the same functions with C12orf65. You can find most of the proteins on our site.

Function	Related Protein
aminoacyl-tRNA hydrolase activity	PTRH2;ICT1;PTRHD1;C12orf65;PTRH1
ribosome binding	CPEB1A;EIF2A;RPN2;SEC61B;ERI1;ICT1;CPEB3;MTOR;C12orf65
translation release factor activity, codon nonspecific	C12orf65;ICT1
NOT translation release factor activity, codon specific	C12orf65;ICT1

C12orf65 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with C12orf65 here. Most of them are supplied by our site. Hope this information will be useful for your research of C12orf65.

CDK2

Akabane, S; Ueda, T; et al. Ribosome Rescue and Translation Termination at Non-Standard Stop Codons by ICT1 in Mammalian Mitochondria. PLOS GENETICS 10:-(2014).

Spiegel, R; Mandel, H; et al. Delineation of C12orf65-related phenotypes: a genotype-phenotype relationship. EUROPEAN JOURNAL OF HUMAN GENETICS 22:-(2014).