C1QA
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Official Full Name
complement component 1, q subcomponent, alpha polypeptide
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Overview
C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes. -
Synonyms
C1QA; complement component 1, q subcomponent, alpha polypeptide; C1q; AI255395; complement C1q subcomponent subunit A;
- Recombinant Proteins
- Cell & Tissue Lysates
- Native Proteins
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Zebrafish
- E. coli
- E.coli
- HEK293
- Human Serum
- Insect Cell
- Mammalian Cell
- Yeast
- C
- His
- GST
- His (Fc)
- Avi
- Myc
- His|T7
- SUMO
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- C1QA Related Articles
- C1QA Related Research Area
C1QA involved in several pathways and played different roles in them. We selected most pathways C1QA participated on our site, such as Complement and coagulation cascades, Prion diseases, Pertussis, which may be useful for your reference. Also, other proteins which involved in the same pathway with C1QA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Complement and coagulation cascades | BDKRB2;SERPINF2;CR1L;C8G;Hc;Serpina1c;PROC;C1S;C4BPB |
Prion diseases | HSPA1A;PRKACA;MAPK1;PRKACG;IL1A;C8A;SOD1;MAP2K1;C6 |
Pertussis | C4BPA;AMCF-II;ITGB1;SERPING1;RELA;GNAI3;MAPK12;ITGB2L;MAPK3 |
Chagas disease (American trypanosomiasis) | MAPK11;PIK3CB;IRAK4;PPP2R1A;PPP2R2C;NFKB1;SERPINE1;FOS;TGFBR1 |
Staphylococcus aureus infection | MASP1;PTAFR;HLA-DRA;SELPLG;MBL1;H2-AA;DSG1A;ITGB2;CFH |
Systemic lupus erythematosus | HIST1H3F;HIST2H3C1;FCGR3A;HIST1H3D;TNF;HIST2H2BB;HLA-DRB1;HIST1H2BN;HLA-DOA |
C1QA has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by C1QA itself. We selected most functions C1QA had, and list some proteins which have the same functions with C1QA. You can find most of the proteins on our site.
Function | Related Protein |
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protein binding | ATP1A2;FCER1G;PAX8;TRIM43;HNRNPAB;KIRREL2;SCAMP5;ETS2;FRS2 |
C1QA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with C1QA here. Most of them are supplied by our site. Hope this information will be useful for your research of C1QA.
C1QB; C1QC; LRP1; SGTA; PIAS2; PPP1CC; BAG6; PPP1CA; SLC25A47; GNPNAT1; HIPK3; q9k5j5_bacan; UBQLN2; UBQLN1; APOA1
- Q&As
- Reviews
Q&As (7)
Ask a questionIt plays a role in recognizing and promoting the removal of apoptotic cells.
Strategies are being explored to modulate C1QA activity in conditions like lupus and rheumatoid arthritis.
Genetic deficiencies in C1QA are linked to increased susceptibility to infections and autoimmune conditions.
C1QA is involved in immune responses against pathogens and in the clearance of immune complexes.
Dysregulation of C1QA can contribute to impaired clearance of immune complexes, leading to autoimmune diseases.
It binds to antibodies or C-reactive protein on pathogen surfaces, activating C1r and C1s in the C1 complex.
C1QA is a vital component of the C1 complex, initiating the classical complement pathway.
Customer Reviews (3)
Write a reviewExcellent quality, fast delivery.
Reliable in experiments, quality.
Product met all requirements.
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