PRSS7
-
Official Full Name
TMPRSS15 transmembrane protease, serine 15
-
Overview
This gene encodes an enzyme that converts the pancreatic proenzyme trypsinogen to trypsin, which activates other proenzymes including chymotrypsinogen and procarboxypeptidases. The precursor protein is cleaved into two chains that form a heterodimer linked by a disulfide bond. This protein is a member of the trypsin family of peptidases. Mutations in this gene cause enterokinase deficiency, a malabsorption disorder characterized by diarrhea and failure to thrive. -
Synonyms
ENTK; PRSS7; MGC133046; enteropeptidase; enterokinase; serine protease 7; OTTHUMP00000083248; protease, serine, 7 (enterokinase);
- Recombinant Proteins
- Native Proteins
- Assay Kits
- Bovine
- Pig
- E.coli
- HEK293
- Yeast
- N/A
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
---|---|---|---|---|---|---|
Bovine | PRSS7-25B | Recombinant Bovine Enterokinase | E.coli | N/A | ||
Bovine | PRSS7-02B | Recombinant Bovine Enterokinase | Yeast | N/A | ||
Bovine | PRSS7-286B | Recombinant Bovine PRSS7 | HEK293 | N/A | ||
Pig | PRSS7-42P | Native Porcine Enterokinase | N/A | |||
Kit-0739 | PRSS7 Assay/Inhibitor Screening Fluorometric Kit | N/A | ||||
Kit-0738 | PRSS7 Activity Fluorometric Assay Kit | N/A |
- Background
- Involved Pathway
- Protein Function
- Interacting Protein
What is PRSS7 protein?
PRSS7 protein, also known as trypsinogen 7 or trypsinogen VII, is a serine protease belonging to the trypsin family. It is primarily produced in the pancreas and secreted into the digestive system, where it plays a role in the breakdown and digestion of proteins. PRSS7 is initially synthesized as an inactive precursor known as trypsinogen, which is then activated through enzymatic cleavage to form the active trypsin enzyme. Trypsin is essential for the digestion of dietary proteins and also contributes to various physiological processes, such as blood coagulation and inflammation.
What is the function of PRSS7 protein?
The main function of PRSS7 is to aid in the digestion of proteins by catalyzing their breakdown into smaller peptides. It does this by cleaving peptide bonds within protein molecules. Additionally, PRSS7 has been implicated in certain pathological conditions, such as pancreatic inflammation and pancreatic cancer, although its precise role in these diseases is still being studied.
PRSS7 related signaling pathway
The signaling pathways associated with PRSS7 activity are not well-documented. However, it is known that the activation of PRSS7 involves proteolytic cleavage and activation of trypsinogen into trypsin by other proteases or the acidic environment of the gastrointestinal tract. Once activated, trypsin can further activate other proteases and initiate downstream signaling cascades involved in protein digestion and related biological processes.
PRSS7 Related Diseases
- Pancreatitis: Mutations or abnormal regulation of PRSS7 can lead to pancreatitis, an inflammation of the pancreas. This can result in symptoms such as abdominal pain, nausea, vomiting, and digestive problems.
- Pancreatic cancer: PRSS7 has been implicated in the development and progression of pancreatic cancer. Changes in PRSS7 expression or activity may contribute to the uncontrolled growth and spread of cancer cells in the pancreas.
- Cystic fibrosis: In individuals with cystic fibrosis, the PRSS7 protein may be abnormally processed and regulated, leading to the obstruction of the pancreatic ducts and impaired pancreatic function.
- Bacterial infections: PRSS7 plays a role in innate immune defense by directly killing bacteria. Dysregulation of PRSS7 expression or activity may contribute to increased susceptibility to bacterial infections.
- Pancreatitis: Mutations in the PRSS7 gene have been linked to hereditary pancreatitis, a condition characterized by inflammation of the pancreas. These mutations can lead to the activation of PRSS7 prematurely, causing tissue damage and pancreatitis.
- Pancreatic cancer: Overexpression of PRSS7 has been observed in pancreatic cancer cells. This suggests that PRSS7 may contribute to the progression and metastasis of pancreatic cancer.
- Liver fibrosis: Studies have shown that PRSS7 expression is increased in activated hepatic stellate cells, which play a key role in the development of liver fibrosis. PRSS7 may promote liver fibrosis by activating transforming growth factor-beta (TGF-β) and other profibrotic pathways.
- Pancreatitis: Mutations in the PRSS7 gene have been linked to hereditary pancreatitis, a condition characterized by inflammation of the pancreas. These mutations can lead to the activation of PRSS7 prematurely, causing tissue damage and pancreatitis.
- Pancreatic cancer: Overexpression of PRSS7 has been observed in pancreatic cancer cells. This suggests that PRSS7 may contribute to the progression and metastasis of pancreatic cancer.
- Liver fibrosis: Studies have shown that PRSS7 expression is increased in activated hepatic stellate cells, which play a key role in the development of liver fibrosis. PRSS7 may promote liver fibrosis by activating transforming growth factor-beta (TGF-β) and other profibrotic pathways.
PRSS7 involved in several pathways and played different roles in them. We selected most pathways PRSS7 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with PRSS7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
---|
PRSS7 has several biochemical functions, for example, scavenger receptor activity, serine-type endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PRSS7 itself. We selected most functions PRSS7 had, and list some proteins which have the same functions with PRSS7. You can find most of the proteins on our site.
Function | Related Protein |
---|---|
scavenger receptor activity | TMPRSS3;CD6;CD163L1;ACKR4;SUSD2;ABHD1;DMBT1;LOXL2;ENPP1 |
serine-type endopeptidase activity | F9A;GZMH;KLK1B11;KLK7;KLK1B5;PRSS45;OVCH2;MCPT9;TMPRSS3 |
PRSS7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRSS7 here. Most of them are supplied by our site. Hope this information will be useful for your research of PRSS7.
- Q&As
- Reviews
Q&As (5)
Ask a questionPRSS7 dysregulation has been linked to conditions such as pancreatitis and pancreatic cancer, highlighting its clinical significance in these diseases.
PRSS7 has been studied in the context of inflammatory conditions and may have implications beyond pancreatic disorders.
The potential side effects of targeting PRSS7 for therapy would need careful consideration and further research.
Some diagnostic tests measure PRSS7 levels in blood or other biological samples to assess pancreatic function and health.
Yes, abnormal levels or activity of PRSS7 have been implicated in certain pancreatic disorders, making it a potential biomarker for diagnostic purposes.
Customer Reviews (3)
Write a reviewTheir expertise and prompt assistance can effectively address any concerns or challenges that may arise during the experimental process.
The PRSS7 protein is of exceptional quality, making it an ideal choice to meet my experimental requirements.
In addition to its outstanding quality, the manufacturer of the PRSS7 protein provides excellent technical support, which is a valuable asset for researchers
Ask a Question for All PRSS7 Products
Required fields are marked with *
My Review for All PRSS7 Products
Required fields are marked with *