FDXR
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Official Full Name
Ferredoxin Reductase
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Overview
Ferredoxin reductase is a ubiquitous flavoenzyme, containing noncovalently bound FAD as a prosthetic group. It plays a role in delivering NADPH or low potential one-electron donors such as ferredoxin and flavodoxin to redox-based metabolisms in plastids, mitochondria and bacteria. In mammals, ferredoxin reductase is loosely associated with the inner mitochondrial membrane and receives electrons from NADPH. These electrons are transferred to ferredoxin which shuttles electrons to cytochrome P450 in the adrenal cortex mitochondrial steroid hydroxylation systems. -
Synonyms
FDXR; ferredoxin reductase; ADXR; NADPH: adrenodoxin oxidoreductase, mitochondrial; AR; adrenodoxin reductase; ferredoxin--NADP(+) reductase; NP_004101.2; EC 1.18.1.2; NP_077728.2;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Bovine
- E.coli
- Human
- Mouse
- Rat
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- Yeast
- GST
- His
- His (Fc)
- Avi
- His|T7
- SUMO
- Myc
- DDK
- Myc|DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- FDXR Related Articles
FDXR involved in several pathways and played different roles in them. We selected most pathways FDXR participated on our site, such as Biological oxidations, Cytochrome P450 - arranged by substrate type, Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR), which may be useful for your reference. Also, other proteins which involved in the same pathway with FDXR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
---|---|
Biological oxidations | CYP1A1;UGT1B7;CYP2K17;CYP11A1;ADH8B;CYP51A1;CYP2V1;CYP7A1;CYP2W1 |
Cytochrome P450 - arranged by substrate type | CYP4T8;CYP2K8;CYP2K17;CYP7A1;CYP2AD2;CYP4F12;CYP2AD6;CYP2A6;CYP2F1 |
Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR) | FDX1L;FDX1;CYP11A1;FDXR |
Direct p53 effectors | CTSD;FOXA1;ZNF385A;GDF15;GADD45A;SMARCA4;DGCR8;DDB2;BCL2L14 |
Disease | TNKS2;RCC1;HDAC5;PRELP;MTRR;PPIAL4A;CFTR;JAG2;RBP4 |
Diseases of metabolism | AMN;CYP11A1;CCDC59;MMADHC;FDX1;FDXR;MTRR;FDX1L;GYG2 |
Electron transport from NADPH to Ferredoxin | FDXR;FDX1;FDX1L |
Endogenous sterols | CYP19A1;CYP11B1;FDXR;FDX1L;CYP21A2;CYP11B2;CYP46A1;CYP7A1;CYP11A1 |
FDXR has several biochemical functions, for example, NADPH-adrenodoxin reductase activity, ferredoxin-NADP+ reductase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FDXR itself. We selected most functions FDXR had, and list some proteins which have the same functions with FDXR. You can find most of the proteins on our site.
Function | Related Protein |
---|---|
NADPH-adrenodoxin reductase activity | |
ferredoxin-NADP+ reductase activity | |
protein binding | INTS3;BLOC1S6;GPR37L1;FANCC;NME2;CA2;COMMD1;MPZL2B;KRT15 |
FDXR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FDXR here. Most of them are supplied by our site. Hope this information will be useful for your research of FDXR.
FHIT; HSPD1
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