GAD1
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Official Full Name
glutamate decarboxylase 1 (brain, 67kDa)
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Overview
Glutamic Acid Decarboxylase (GAD) catalyzes the conversion of L-glutamate to gamma-aminobutyric acid (GABA), the principal inhibitory neurotransmitter in the brain, and a putative paracrine signal molecule in pancreatic islets. GAD67 is a cytoplasmic protein and is encodes on chromosome 2. -
Synonyms
GAD1; glutamate decarboxylase 1 (brain, 67kDa); GAD, glutamate decarboxylase 1 (brain, 67kD); glutamate decarboxylase 1; GAD-67; 67 kDa glutamic acid decarboxylase; glutamate decarboxylase 67 kDa isoform; GAD; SCP; CPSQ1; FLJ45882;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- E.coli
- HEK293
- HEK293 cells
- HEK293T
- In Vitro Cell Free System
- Insect Cell
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- His|GST
- His|S
- Myc
- DDK
- Myc|DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- GAD1 Related Articles
- GAD1 Related Research Area
GAD1 involved in several pathways and played different roles in them. We selected most pathways GAD1 participated on our site, such as Alanine, aspartate and glutamate metabolism, beta-Alanine metabolism, Taurine and hypotaurine metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with GAD1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Alanine, aspartate and glutamate metabolism | GAD1B;GLSA;IL4I1;GLUD1A;RIMKLA;GAD1;FOLH1;GPT2;ABAT |
beta-Alanine metabolism | ACADM;SRM;ALDH1A3;ALDH3A1;GAD1;AOC2;CARNS1;ALDH7A1;HIBCH |
Taurine and hypotaurine metabolism | GGT7;GAD1;CDO1;GGT5;GGT5A;ADOB;GGT1;GGT1A;BAAT |
Butanoate metabolism | Acsm2a;GAD1;BDH2;HMGCLL1;ACSM2;HADHA;ACSM5;HMGCS1;OXCT1 |
Metabolic pathways | AMY2A5;DNMT3AB;MUT;NT5C2;QDPR;ALDH2.2;PPCDC;ST3GAL5;PTGS2A |
GABAergic synapse | GABRR3;GABRE;PRKACG;GNB4;GNB3;GABRR1;GABRB1;GABRA4;GABBR1 |
Type I diabetes mellitus | HLA-DQB1;HLA-DRB5;INS;LTA;CPE;HLA-DRB3;IL12B;HLA-DRB4;IL1B |
GAD1 has several biochemical functions, for example, glutamate decarboxylase activity, protein binding, pyridoxal phosphate binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GAD1 itself. We selected most functions GAD1 had, and list some proteins which have the same functions with GAD1. You can find most of the proteins on our site.
Function | Related Protein |
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glutamate decarboxylase activity | GLUL;GAD2;GAD1;GAD1B |
protein binding | SLC48A1;USH1C;PPIG;PINK1;NFE2L2;PSMD11;ALDOC;MERTK;TEAD3 |
pyridoxal phosphate binding | GOT2;CCBL2;HINT2;SPTLC2B;PROSC;CTH;GOT1;ACCS;GPT |
GAD1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GAD1 here. Most of them are supplied by our site. Hope this information will be useful for your research of GAD1.
HAAO; CMTM5; STK3; AGTRAP; ABL1; JUN; FYN; NCK1; GRB2
- Q&As
- Reviews
Q&As (5)
Ask a questionMolecular techniques such as PCR (Polymerase Chain Reaction) and genetic sequencing are employed to investigate mutations and variations in the GAD1 gene.
Altered GAD1 function can disrupt the balance of GABAergic neurotransmission, potentially contributing to the development or exacerbation of anxiety disorders.
Investigating GAD1 as a therapeutic target may offer novel approaches to modulate GABAergic signaling and manage conditions associated with its dysregulation.
In some cases, alterations in GAD1 expression levels have been proposed as potential biomarkers for specific neurological and psychiatric disorders.
Yes, genetic polymorphisms in the GAD1 gene have been identified, and variations may influence an individual's susceptibility to certain neurological and psychiatric disorders.
Customer Reviews (3)
Write a reviewOne advantage of using GAD1 protein in trials is its versatility.
GAD1 is a key regulator of cellular structure and function, particularly in the context of maintaining the integrity of the cell membrane and organizing cytoskeletal components.
GAD1 can be used in various experimental setups and assays, including in vitro cell culture studies, animal models, and even clinical investigations.
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