Tnfrsf18
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Official Full Name
tumor necrosis factor receptor superfamily, member 18
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Overview
This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased;expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance;maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in;the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript;variants of this gene encoding distinct isoforms have been reported. -
Synonyms
TNFRSF18; tumor necrosis factor receptor superfamily, member 18; tumor necrosis factor receptor superfamily member 18; glucocorticoid-induced TNFR-related protein; AITR; Gitr;
- Recombinant Proteins
- Cell & Tissue Lysates
- GMP Proteins
- Protein Pre-coupled Magnetic Beads
- Canine
- Chicken
- Cynomolgus
- Cynomolgus Monkey
- Human
- Mouse
- Mus musculus (Mouse)
- Rat
- Rhesus macaque
- Rhesus monkey
- Zebrafish
- CHO cells
- E.coli
- E.coli expression system
- HEK293
- HEK293T
- Human Cell
- Human cells
- Insect Cell
- Mammalian cell
- Mammalian Cell
- Mammalian cells
- C
- Fc
- His
- mFc
- 6×His
- DYKDDDDK
- Avi
- Flag
- GST
- hFc
- hIgG1
- hIgG4
- His (Fc)
- His|GST
- His|HIgG
- human|IgG1|Fc
- MlgG1 Fc
- Mouse|IgG2a|Fc
- Myc
- DDK
- Myc|DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- Tnfrsf18 Related Gene Family
- Tnfrsf18 Related Research Area
- Tnfrsf18 Related Signal Pathway
Tnfrsf18 involved in several pathways and played different roles in them. We selected most pathways Tnfrsf18 participated on our site, such as Cytokine-cytokine receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with Tnfrsf18 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Cytokine-cytokine receptor interaction | CCL11;CXCL12;IL10RB;CCR9A;TNFRSF10A;CXCL10;CRFB16;IL1R1;CCR6 |
Tnfrsf18 has several biochemical functions, for example, tumor necrosis factor-activated receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Tnfrsf18 itself. We selected most functions Tnfrsf18 had, and list some proteins which have the same functions with Tnfrsf18. You can find most of the proteins on our site.
Function | Related Protein |
---|---|
tumor necrosis factor-activated receptor activity | TNFRSF4;CD27;TNFRSF11B;TNFRSF25;TNFRSF9A;NRADD;CD40;TNFRSF1A;TNFRSF10B |
Tnfrsf18 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Tnfrsf18 here. Most of them are supplied by our site. Hope this information will be useful for your research of Tnfrsf18.
MYC
- Q&As
- Reviews
Q&As (5)
Ask a questionClinical trials are investigating TNFRSF18 agonists, such as monoclonal antibodies, in combination with other cancer treatments in various cancer types.
As of my knowledge cutoff date in January 2022, there were no approved TNFRSF18-targeted therapies for cancer. However, this may have changed since then.
Side effects may include immune-related adverse events, similar to those seen with other immunotherapies, and can range from mild to severe.
TNFRSF18-targeted therapies may enhance the body's immune response against cancer cells, leading to better tumor control and improved patient outcomes.
Yes, combination therapies involving TNFRSF18 agonists and other immunotherapies are under investigation to improve treatment efficacy.
Customer Reviews (3)
Write a reviewThis flexibility enables researchers like myself to tailor TNFRSF18 protein experiments to our unique needs, enhancing the reliability and relevance of the obtained results.
Their commitment to delivering exceptional products and assisting with any challenges that may arise ensures a successful and rewarding experimental journey.
The TNFRSF18 protein offered by the manufacturer is of exceptional quality, and it meets the rigorous standards necessary for my experimental needs.
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