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HERC2

Official Full Name

hect domain and RLD 2
Overview

This gene belongs to the HERC gene family that encodes a group of unusually large proteins, which contain multiple structural domains. All members have at least 1 copy of an N-terminal region showing homology to the cell cycle regulator RCC1 and a C-terminal HECT (homologous to E6-AP C terminus) domain found in a number of E3 ubiquitin protein ligases. Genetic variations in this gene are associated with skin/hair/eye pigmentation variability.
Synonyms

HERC2; hect domain and RLD 2; E3 ubiquitin-protein ligase HERC2; D15F37S1; jdf2; p528; HECT domain and RCC1 like domain containing protein 2; SHEP1; probable E3 ubiquitin-protein ligase HERC2; hect domain and RCC1-like domain-containing protein 2;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse

Source

E.coli
HEK293
Mammalian Cell

Tag

His
His (Fc)
Avi
No tag

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	HERC2-0433H	Recombinant Human HERC2 Protein (S3951-P4321), His tagged	E.coli	His	S3951-P4321	Inquiry
Human	HERC2-0432H	Recombinant Human HERC2 Protein (S3951-P4321), Tag Free	E.coli	No tag	S3951-P4321	Inquiry
Mouse	HERC2-7580M	Recombinant Mouse HERC2 Protein	Mammalian Cell	His		Inquiry
Mouse	HERC2-4127M	Recombinant Mouse HERC2 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	HERC2-4127M-B	Recombinant Mouse HERC2 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Chicken	HERC2-4573C	Recombinant Chicken HERC2	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
HERC2 Related Articles

HERC2 involved in several pathways and played different roles in them. We selected most pathways HERC2 participated on our site, such as Ubiquitin mediated proteolysis, which may be useful for your reference. Also, other proteins which involved in the same pathway with HERC2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Ubiquitin mediated proteolysis	MID1;BRCA1;CUL2;UBE2NA;UBA7;RBX1;UBR5;UBE3C;UBE2N

HERC2 has several biochemical functions, for example, SUMO binding, UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity, coenzyme F420-0 gamma-glutamyl ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HERC2 itself. We selected most functions HERC2 had, and list some proteins which have the same functions with HERC2. You can find most of the proteins on our site.

Function	Related Protein
SUMO binding	USPL1;CBX4;TDG;PML;USP25;RPS3;HERC2;TOLLIP
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity	NEURL1B;SIAH2L;LTN1;MARCH5L;ZNRF3;HERC2;RNF187;MARCH6;UBR1
coenzyme F420-0 gamma-glutamyl ligase activity	RC3H2;ITCHA;RNF180;MARCH6;DTX1;MARCH9;TRIM50;MARCH5L;UBR1
coenzyme F420-2 alpha-glutamyl ligase activity	TMEM129;ARIH1L;ZNRF2B;RNF144AB;TRIM71;MARCH9;ZNRF3;SIAH2L;MARCH4
ligase activity	PELI3;UBR1;HECW1B;UBE2G1B;RNF111;TRIM5;UBE2CBP;MYLIP;MID2
metal ion binding	ADPRM;ZFAT;CYP2K17;BTR30;LMX1BA;NRXN3A;AMY1B;ZDHHC15B;POLB
protein-glutamic acid ligase activity	MYLIPA;MUL1A;TRIM50;MARCH9;HECW2;RNF169;TRIM41;TRIM71;RAG1
protein-glycine ligase activity	UBE2IB;RNF180;ZNRF3;HECW2;SHRPRBCK1R;ZNRF2B;MARCH9;DTX1;UBR1
protein-glycine ligase activity, elongating	MARCH5L;RNF149;MARCH11;TRIM50;TMEM129;RNF180;HECW2;MYLIPB;UBE2IB
protein-glycine ligase activity, initiating	MYLIPA;MUL1A;NEURL3;RAG1;TRIM41;RNF149;RNF187;MARCH6;SIAH2L
ribosomal S6-glutamic acid ligase activity	ZNRF3;ZNRF2B;LTN1;RNF169;RNF144AB;RFWD2;RNF149;SIAH2L;SHRPRBCK1R
tubulin-glutamic acid ligase activity	ZNRF2B;RNF180;MGRN1A;DTX1;HERC2;MUL1A;TRIM41;MARCH5L;MYLIPA
tubulin-glycine ligase activity	RNF144AA;MARCH6;MARCH11;RFWD2;ARIH1L;ZNRF2B;TRIM41;TMEM129;MUL1A
ubiquitin protein ligase activity	C12orf51;UBE2S;ARIH2;CBLC;ZNRF2;TRIP12;NEURL3;G2E3;ZSWIM2
ubiquitin protein ligase binding	ARRB2;CUL1A;LRPPRC;HM13;ASB4;ARIH1;TRIB2;AXIN2;MAP1LC3C
ubiquitin-protein transferase activity	BARD1;RNF20;ZYG11;FBXO21;MALT1;PARK2;RNF217;DZIP3;TRIM32
zinc ion binding	RBM5;CPA6;BMP1A;CXXC4;ZDHHC22;BTR09;ZNRF1;CPD;ZNF205

HERC2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HERC2 here. Most of them are supplied by our site. Hope this information will be useful for your research of HERC2.

NEURL4; ZBTB5; SSSCA1; SFN; ESCO1

Moroishi, T; Yamauchi, T; et al. HERC2 Targets the Iron Regulator FBXL5 for Degradation and Modulates Iron Metabolism. JOURNAL OF BIOLOGICAL CHEMISTRY 289:16430-16441(2014).

Long, Y; Wang, YB; et al. Neurotoxicity of Perfluorooctane Sulfonate to Hippocampal Cells in Adult Mice. PLOS ONE 8:-(2013).