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HHAT

  • Official Full Name

    hedgehog acyltransferase

  • Overview

    Skinny hedgehog (SKI1) encodes an enzyme that acts within the secretory pathway to catalyze amino-terminal palmitoylation of hedgehog (see MIM 600725).
  • Synonyms

    HHAT; hedgehog acyltransferase; protein-cysteine N-palmitoyltransferase HHAT; FLJ10724; GUP2; MART 2; MART2; rasp; sit; ski; Skn; 2810432O22Rik; AI462858; FLJ34867; AC115917.1; HHAT_HUMAN; MART-2; Melanoma antigen recognized by T cells 2; Melanoma antigen recognized by T-cells 2; MGC11697; OTTMUSP00000033669; Protein cysteine N palmitoyltransferase HHAT; RGD1311746; SKI1; Skinny hedgehog protein 1; Skinny hedgehog protein; OTTHUMP00000034608; OTTHUMP00000034611;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Zebrafish
  • HEK293
  • HEK293T
  • Mammalian Cell
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human HHAT-255H Recombinant Human HHAT Protein, MYC/DDK-tagged HEK293 Myc/DDK
Mouse HHAT-7609M Recombinant Mouse HHAT Protein Mammalian Cell His
Mouse HHAT-4149M Recombinant Mouse HHAT Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Hhat-3389M Recombinant Mouse Hhat Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse HHAT-4149M-B Recombinant Mouse HHAT Protein Pre-coupled Magnetic Beads HEK293
Zebrafish HHAT-6488Z Recombinant Zebrafish HHAT Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • HHAT Related Articles
  • HHAT Related Research Area

HHAT involved in several pathways and played different roles in them. We selected most pathways HHAT participated on our site, such as Hedgehog ligand biogenesis, Signal Transduction, Signaling by Hedgehog, which may be useful for your reference. Also, other proteins which involved in the same pathway with HHAT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Hedgehog ligand biogenesisSCUBE2;HHAT;GPC5A;NOTUM1A;DERL2;NOTUM;DISP2;OS9
Signal TransductionARHGEF3;CRABP1;CLPS;DZIP1;NPB;C;DLC1;CIT;SHARPIN
Signaling by HedgehogSPOP;CDC73;HHAT;NOTUM1A;TTC21B;WDR35;DZIP1;IFT52;IFT172

HHAT has several biochemical functions, for example, 2,4,4-trimethyl-3-oxopentanoyl-CoA 2-C-propanoyl transferase activity, 2,6-dimethyl-5-methylene-3-oxo-heptanoyl-CoA C-acetyltransferase activity, 2-methylhexanoyl-CoA C-acetyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HHAT itself. We selected most functions HHAT had, and list some proteins which have the same functions with HHAT. You can find most of the proteins on our site.

Function Related Protein
2,4,4-trimethyl-3-oxopentanoyl-CoA 2-C-propanoyl transferase activityCML2;MBOAT7;NAT14;LPCAT3;CML5;MBOAT4;MBOAT1;DGAT2L6;ACNAT2
2,6-dimethyl-5-methylene-3-oxo-heptanoyl-CoA C-acetyltransferase activityMBOAT4;CML2;DGAT2L6;HHAT;MBOAT7;ACNAT2;MBOAT1;Acnat1;NAT14
2-methylhexanoyl-CoA C-acetyltransferase activityDGAT2L6;LPCAT3;MBOAT1;Acnat1;NAT14;CML5;CML2;MBOAT7;MBOAT4
3-hydroxybutyryl-CoA thiolase activityMBOAT7;DGAT2L6;LPCAT3;Acnat1;MBOAT1;MBOAT4;CML2;CML5;NAT14
3-ketopimelyl-CoA thiolase activityAcnat1;DGAT2L6;HHAT;ACNAT2;MBOAT1;CML5;NAT14;MBOAT4;CML2
C-acyltransferase activityMBOAT4;HHAT;CML5;LPCAT3;CML2;ACNAT2;MBOAT7;MBOAT1;NAT14
C-palmitoyltransferase activityLPCAT3;MBOAT4;MBOAT7;DGAT2L6;HHAT;CML5;ACNAT2;NAT14;CML2
GTP bindingTUBG2;ACSM5;RAC3;ARL8;RALB;EIF2S3Y;RHOUB;RAB5AA;ARL15A
L-2-aminoadipate N-acetyltransferase activityHHAT;DGAT2L6;ACNAT2;MBOAT7;CML2;Acnat1;MBOAT1;NAT14;CML5
N-acetyltransferase activityNAA40;NAT9;AANAT2;SAT1A.2;SAT2B;NAT14;SAT1A.1;DGAT2L6;Acnat1
N-acyltransferase activityNAT14;Acnat1;HHAT;BAAT;CML5;MBOAT1;ACNAT2;MBOAT7;HRASLS5
N-palmitoyltransferase activityAcnat1;LPCAT3;MBOAT4;DGAT2L6;MBOAT7;ACNAT2;CML5;HHAT;NAT14
N-succinyltransferase activityLPCAT3;CML5;HHAT;DGAT2L6;MBOAT7;ACNAT2;MBOAT4;Acnat1;MBOAT1
O-acetyltransferase activityCML5;Acnat1;DGAT2L6;MBOAT7;ACNAT2;HHAT;NAT14;CML2;LPCAT3
O-acyltransferase activityNAT14;MBOAT7;Acnat1;DGAT1A;PLA2G15;DGAT2L6;HHAT;MBOAT4;CML2
O-octanoyltransferase activityNAT14;DGAT2L6;LPCAT3;MBOAT4;Acnat1;ACNAT2;CML5;HHAT;MBOAT1
O-palmitoyltransferase activityACNAT2;MBOAT4;NAT14;MBOAT1;MBOAT7;CML2;HHAT;CML5;DGAT2L6
O-sinapoyltransferase activityACNAT2;CML2;LPCAT3;MBOAT1;NAT14;CML5;MBOAT7;HHAT;Acnat1
O-succinyltransferase activityHHAT;MBOAT1;CML2;Acnat1;MBOAT7;NAT14;MBOAT4;LPCAT3;DGAT2L6
Ras palmitoyltransferase activityCML2;MBOAT4;ZDHHC9;MBOAT1;Acnat1;LPCAT3;NAT14;MBOAT7;HHAT
S-acetyltransferase activityACNAT2;NAT14;Acnat1;CML5;DGAT2L6;MBOAT4;LPCAT3;MBOAT7;MBOAT1
S-acyltransferase activityACNAT2;LPCAT3;HHAT;MBOAT7;Acnat1;DGAT2L6;NAT14;CML5;MBOAT1
S-malonyltransferase activityLPCAT3;Acnat1;CML5;HHAT;DGAT2L6;MBOAT7;MBOAT4;CML2;MBOAT1
S-succinyltransferase activityCML2;CML5;ACNAT2;MBOAT1;Acnat1;MBOAT4;MBOAT7;LPCAT3;NAT14
UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase activityNAT14;MBOAT4;HHAT;CML2;Acnat1;MBOAT7;ACNAT2;MBOAT1;DGAT2L6
acetyl-CoA:L-lysine N6-acetyltransferaseCML2;CML5;HHAT;NAT14;DGAT2L6;MBOAT1;Acnat1;MBOAT4;LPCAT3
acetyltransferase activityACNAT2;AANAT2;AANAT1;EP300;KAT6B;CML5;CML2;KAT8;MBOAT1
acyl-CoA N-acyltransferase activityMBOAT4;DGAT2L6;CML5;NAT14;CML2;ACNAT2;LPCAT3;MBOAT1;Acnat1
acylglycerol O-acyltransferase activityMBOAT1;MBOAT4;Acnat1;LPCAT3;DGAT2L6;CML2;NAT14;HHAT;ACNAT2
azetidine-2-carboxylic acid acetyltransferase activityMBOAT1;HHAT;LPCAT3;DGAT2L6;CML5;ACNAT2;MBOAT4;Acnat1;MBOAT7
benzoyl acetate-CoA thiolase activityCML2;MBOAT1;DGAT2L6;CML5;HHAT;MBOAT7;MBOAT4;Acnat1;ACNAT2
butyryl-CoA 2-C-propionyltransferase activityNAT14;CML5;MBOAT7;MBOAT4;CML2;ACNAT2;Acnat1;HHAT;MBOAT1
carnitine O-acyltransferase activityCML5;DGAT2L6;MBOAT1;MBOAT7;CML2;LPCAT3;Acnat1;ACNAT2;MBOAT4
dihydrolipoamide S-acyltransferase activityAcnat1;HHAT;NAT14;DGAT2L6;ACNAT2;MBOAT7;CML2;MBOAT4;CML5
dihydrolipoamide branched chain acyltransferase activityCML2;MBOAT7;DGAT2L6;NAT14;MBOAT1;CML5;LPCAT3;MBOAT4;HHAT
ergosterol O-acyltransferase activityACNAT2;MBOAT7;NAT14;CML2;DGAT2L6;MBOAT1;Acnat1;HHAT;LPCAT3
glucosaminyl-phosphotidylinositol O-acyltransferase activityMBOAT7;DGAT2L6;NAT14;LPCAT3;ACNAT2;Acnat1;MBOAT1;MBOAT4;CML2
keto acid formate lyase activityCML2;Acnat1;MBOAT4;LPCAT3;HHAT;MBOAT1;ACNAT2;DGAT2L6;NAT14
lanosterol O-acyltransferase activityACNAT2;MBOAT7;CML2;DGAT2L6;MBOAT4;LPCAT3;CML5;Acnat1;MBOAT1
malonyltransferase activityNAT14;Acnat1;HHAT;DGAT2L6;MBOAT4;CML5;MBOAT7;ACNAT2;LPCAT3
myristoyltransferase activityHHAT;MBOAT1;MBOAT4;CML2;NAT14;Acnat1;ACNAT2;MBOAT7;DGAT2L6
naphthyl-2-oxomethyl-succinyl-CoA succinyl transferase activityCML5;HHAT;NAT14;MBOAT4;CML2;Acnat1;MBOAT7;ACNAT2;DGAT2L6
nucleotide bindingJAK2B;PAK2B;RHOGA;TSSK1;BMPR2B;EIF3G;RBFOX3;HNRNPL;ACVR2AA
octanoyltransferase activityHHAT;DGAT2L6;LPCAT3;ACNAT2;MBOAT7;CML2;Acnat1;MBOAT1;NAT14
palmitoleoyl [acyl-carrier-protein]-dependent acyltransferase activityAcnat1;CML5;MBOAT1;MBOAT7;CML2;HHAT;MBOAT4;LPCAT3;DGAT2L6
palmitoyltransferase activityLPCAT3;ZDHHC9;MBOAT1;ZDHHC18;ZDHHC3;HHAT;NAT14;ZDHHC20;ZDHHC2
peptidyl-lysine N-acetyltransferase activity, acting on acetyl phosphate as donorNAA50;CML2;NAT14;MBOAT4;LPCAT3;ACNAT2;DGAT2L6;HHAT;CML5
peptidyl-lysine N6-myristoyltransferase activityCML2;DGAT2L6;CML5;MBOAT1;ACNAT2;MBOAT7;HHAT;MBOAT4;NAT14
peptidyl-lysine N6-palmitoyltransferase activityMBOAT7;DGAT2L6;MBOAT1;CML5;LPCAT3;Acnat1;ACNAT2;CML2;NAT14
protein-cysteine S-acyltransferase activityHHAT;ACNAT2;Acnat1;CML5;MBOAT4;MBOAT1;LPCAT3;CML2;DGAT2L6
protein-cysteine S-myristoyltransferase activityCML5;MBOAT7;NAT14;MBOAT4;HHAT;ACNAT2;DGAT2L6;Acnat1;LPCAT3
serine O-acyltransferase activityHHAT;LPCAT3;Acnat1;MBOAT4;ACNAT2;NAT14;MBOAT1;CML2;CML5
sinapoyltransferase activityDGAT2L6;CML2;MBOAT1;NAT14;MBOAT4;ACNAT2;LPCAT3;MBOAT7;CML5
sterol O-acyltransferase activityMBOAT4;MBOAT7;LPCAT3;SOAT1;DGAT2L6;CML2;CML5;HHAT;NAT14
succinyltransferase activityACNAT2;Acnat1;NAT14;CML2;DGAT2L6;MBOAT4;MBOAT7;HHAT;MBOAT1
transferase activityHECTD1;B3GAT1A;REV3L;CTU1;METTL8;NR5A1B;PIGB;OGT.1;GKUP
transferase activity, transferring acyl groupsMBOAT7;ESCO1;CHATB;LIPT1;PIGW;ZDHHC5A;CML5;ZDHHC24;CRATA

HHAT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HHAT here. Most of them are supplied by our site. Hope this information will be useful for your research of HHAT.

Katoh, Y; Katoh, M; et al. Hedgehog signaling pathway and gastric cancer. CANCER BIOLOGY & THERAPY 4:1050-1054(2005).
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