HFE2
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Official Full Name
hemochromatosis type 2 (juvenile)
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Overview
The product of this gene is involved in iron metabolism. It may be a component of the signaling pathway which activates hepcidin or it may act as a modulator of hepcidin expression. It could also represent the cellular receptor for hepcidin. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Defects in this gene are the cause of hemochromatosis type 2A, also called juvenile hemochromatosis (JH). JH is an early-onset autosomal recessive disorder due to severe iron overload resulting in hypogonadotrophic hypogonadism, hepatic fibrosis or cirrhosis and cardiomyopathy, occurring typically before age of 30. -
Synonyms
HFE2; hemochromatosis type 2 (juvenile); hemojuvelin; haemojuvelin; HFE2A; HJV; JH; repulsive guidance molecule c; RGMC; RGM domain family member C; hemochromatosis type 2 protein; MGC23953;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Cynomolgus Monkey
- Human
- Mouse
- Zebrafish
- E.coli
- HEK293
- HEK293F
- Human Cell
- Insect Cell
- Insect Cells
- Mammalian Cell
- Wheat Germ
- C
- His
- Flag
- GST
- His (Fc)
- Avi
- His|Fc
- His|GST
- His|T7
- N/A
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | HFE2-4722H | Recombinant Human HFE2 Protein, GST-tagged | Wheat Germ | GST | ||
Human | HFE2-2082H | Recombinant Human HFE2 protein, His-tagged | E.coli | His | Lys234~Ser416 | |
Human | HFE2-2419H | Recombinant Human Hemochromatosis Type 2 (Juvenile), FLAG-tagged | Human Cell | Flag | ||
Human | HFE2-7288H | Recombinant Human HFE2 protein(Met1-Ser399), His-tagged | Insect Cells | C-His | Met1-Ser399 | |
Human | HFE2-2083H | Recombinant Human HFE2 protein, His & T7-tagged | E.coli | His/T7 | Leu29~Ala401 (Accession # Q6ZVN8) | |
Human | HFE2-469H | Recombinant Human HFE2 protein, His & Fc-tagged | HEK293F | His/Fc | Gln36~Asp400 | |
Human | HFE2-2084H | Recombinant Human HFE2 protein, His & GST-tagged | E.coli | His/GST | Gln36~Phe200 (Accession # Q6ZVN8) | |
Human | HFE2-423HCL | Recombinant Human HFE2 cell lysate | Insect Cell | N/A | ||
Mouse | HFE2-7602M | Recombinant Mouse HFE2 Protein | Mammalian Cell | His | ||
Mouse | HFE2-4145M-B | Recombinant Mouse HFE2 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Mouse | HFE2-4145M | Recombinant Mouse HFE2 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Cynomolgus Monkey | HFE2-205C | Recombinant Cynomolgus HFE2, His-tagged | Insect Cell | His | Met1-Ser400 | |
Cynomolgus Monkey | HFE2-001CCL | Recombinant Cynomolgus HFE2 cell lysate | Insect Cell | N/A | ||
Zebrafish | HFE2-4276Z | Recombinant Zebrafish HFE2 | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
HFE2 involved in several pathways and played different roles in them. We selected most pathways HFE2 participated on our site, such as Axon guidance, BMP receptor signaling, Developmental Biology, which may be useful for your reference. Also, other proteins which involved in the same pathway with HFE2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Axon guidance | EFNA5;PEBP1;SEMA3G;LRRC4;EPHB4B;ARPC2;ITGB1B.1;Ntng2;SEMA7A |
BMP receptor signaling | CTDSP1;RGMB;CHRDL1;SOSTDC1;SKI;RGMA;CALML4;GREM1;CTDSP2 |
Developmental Biology | PLXNC1;EZRA;CACNG2;FGF18B;SIAH2;CAP1;KBTBD7;SCN3B;TRPC7 |
Netrin-1 signaling | RGMB;PITPNA;NTN1A;RGMA;NTN1B;TRPC5;HFE2;RNF8;TRPC4 |
HFE2 has several biochemical functions, for example, BMP binding, contributes_to BMP receptor activity, coreceptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HFE2 itself. We selected most functions HFE2 had, and list some proteins which have the same functions with HFE2. You can find most of the proteins on our site.
Function | Related Protein |
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BMP binding | TCAP;BMPR2;GREM2;NBL1;CER1;GDF5;GREM1;HFE2 |
contributes_to BMP receptor activity | |
coreceptor activity | CD80;RGMA;CD28;RAMP1;CCR8;CCR5;RAMP3;IGSF1;ACVR2A |
glycoprotein binding | RASA1;PTBP3;LCK;FBXO17;THBS1;IGF2R;BMPR1B;LACRT;DNAJC5 |
protein binding | FAM109B;CDAN1;HUWE1;APOA1BP;TA;KIR2DL1;ELMO2;EDAR;MED22 |
receptor binding | MYO1C;NRG3;SMARCD3;Ren1;GRIN2A;WNT7A;CX3CL1;CXCL10;LPL |
transferrin receptor binding | SNX1;CD81;HFE2;RGMA;HFE;SNX2;Trf;TF;SNX4 |
HFE2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HFE2 here. Most of them are supplied by our site. Hope this information will be useful for your research of HFE2.
- Q&As
- Reviews
Q&As (7)
Ask a questionHFE2 responds to anemia and hypoxic conditions, adjusting iron metabolism to meet physiological needs.
Changes in HFE2 function can lead to liver diseases and cardiomyopathy due to abnormal iron accumulation.
HFE2 impacts intestinal iron absorption, influencing how the body takes up and stores iron.
HFE2 regulates systemic iron levels, ensuring balance between iron uptake, storage, and utilization.
HFE2 is involved in hereditary hemochromatosis, with its dysfunction leading to iron accumulation in organs.
Mutations or deficiencies in HFE2 can cause iron overload, disrupting normal iron metabolism.
HFE2 is crucial in regulating iron metabolism, controlling hepcidin levels to maintain iron homeostasis.
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