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HSF4

Official Full Name

heat shock transcription factor 4
Overview

Heat-shock transcription factors (HSFs) activate heat-shock response genes under conditions of heat or other stresses.HSF4 lacks the carboxyl-terminal hydrophobic repeat which is shared among all vertebrate HSFs and has been suggested to be involved in the negative regulation of DNA binding activity. Two alternatively spliced transcripts encoding distinct isoforms and possessing different transcriptional activity have been described.
Synonyms

HSF4; heat shock transcription factor 4; cataract, Marner , CTM; heat shock factor protein 4; HSF 4; hHSF4; HSTF 4; CTM;

Type

Recombinant Proteins
Cell & Tissue Lysates

Species

Chicken
Human
Mouse
Rat
Zebrafish

Source

E.coli
Mammalian Cell
Wheat Germ

Tag

GST
His
His|GST
His|T7
N/A
N

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	HSF4-716H	Recombinant Human HSF4 Protein, His-tagged	E.coli	His		Inquiry
Human	HSF4-29388TH	Recombinant Human HSF4	Wheat Germ	N/A	100 amino acids	Inquiry
Human	HSF4-5662H	Recombinant Human HSF4 protein, His & GST-tagged	E.coli	His/GST	Val171~Arg284 (Accession # Q9ULV5)	Inquiry
Human	HSF4-5091H	Recombinant Human HSF4 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	HSF4-821HCL	Recombinant Human HSF4 cell lysate		N/A		Inquiry
Human	HSF4-2675H	Recombinant Human HSF4 Protein (Val171-Arg284), N-GST tagged	E.coli	N-GST	Val171-Arg284	Inquiry
Mouse	Hsf4-5663M	Recombinant Mouse Hsf4 protein, His & T7-tagged	E.coli	His/T7	Glu159~Asp411 (Accession # Q9R0L1)	Inquiry
Rat	Hsf4-5664R	Recombinant Rat Hsf4 protein, His & T7-tagged	E.coli	His/T7	Leu91~Met407 (Accession # D4A5A8)	Inquiry
Zebrafish	HSF4-2111Z	Recombinant Zebrafish HSF4	Mammalian Cell	His		Inquiry
Chicken	HSF4-4064C	Recombinant Chicken HSF4	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein

HSF4 involved in several pathways and played different roles in them. We selected most pathways HSF4 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with HSF4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

HSF4 has several biochemical functions, for example, protein phosphatase binding, sequence-specific DNA binding, transcription corepressor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HSF4 itself. We selected most functions HSF4 had, and list some proteins which have the same functions with HSF4. You can find most of the proteins on our site.

Function	Related Protein
protein phosphatase binding	ANAPC5;MAP3K5;PARD3;EIF2AK3;JAK1;JAK3;PPP6R1;SKAP1;CDH5
sequence-specific DNA binding	EMX2;FOXD2;LHX2B;E2F1;IRX1A;RX3;ZNF192;CREB5;TRP53
transcription corepressor activity	ANKRD1;NEUROD2;NRIP1;WNT4;TFCP2L1;SKOR1B;NCOR1;PPP1R13L;SSX3
transcription factor activity, sequence-specific DNA binding	HIC1;NFE2L2B;FOS;ESRRGA;ATF4B1;ZBTB48;DRAP1;NFE2L2;GABPA

HSF4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HSF4 here. Most of them are supplied by our site. Hope this information will be useful for your research of HSF4.

NUDT21; CDK2AP2; ZBED8; BCL6; HSF1; HSF2; TARBP1; FKBP5; RABEP1; SESTD1; MYO15A; SUGT1; TIMM13