INPPL1
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Official Full Name
inositol polyphosphate phosphatase-like 1
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Overview
SH2-containing inositol phosphatase 1 (SHIP1) is a hematopoietic phosphatase that hydrolyzes phosphatidylinositol-3,4,5-triphosphate to phosphatidylinositol-3,4-bisphosphate. SHIP1 is a cytosolic phosphatase with an SH2 domain in its amino terminus and tw -
Synonyms
INPPL1; inositol polyphosphate phosphatase-like 1; phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2; 51C protein; SHIP2; SHIP-2; INPPL-1; protein 51C; SH2 domain-containing inositol 5-phosphatase 2; SH2 domain-containing inositol-5-phosphatase 2;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Rhesus Macaque
- E.coli
- HEK293
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- Involved Pathway
- Protein Function
- Interacting Protein
- INPPL1 Related Articles
- INPPL1 Related Research Area
INPPL1 involved in several pathways and played different roles in them. We selected most pathways INPPL1 participated on our site, such as Inositol phosphate metabolism, Phosphatidylinositol signaling system, B cell receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with INPPL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Inositol phosphate metabolism | ITPK1A;PLCB4;MTMR1A;INPP5A;NUDT3B;PIK3CD;PIP5K1B;PIK3C2B;PLCE1 |
Phosphatidylinositol signaling system | MTMR7;MTMR14;MTMR7B;PI4KA;PIKFYVE;ITPR3;TMEM55A;CALML3;MTMR6 |
B cell receptor signaling pathway | HDAC5;NFKBIE;RASGRP3;CDK7;DOK1B;ARPC4;ARPC2;FCGR2B;AKT2 |
Fc gamma R-mediated phagocytosis | ASAP2;SYK;MAPK1;AKT2;PRKCD;LAT;PLA2G4D;HCK;PIP5K1B |
Insulin signaling pathway | TRIP10A;PHKB;MTOR;SHC3;FBP1B;PYGM;FBP1;PTPRFB;AKT2 |
INPPL1 has several biochemical functions, for example, SH2 domain binding, SH3 domain binding, actin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by INPPL1 itself. We selected most functions INPPL1 had, and list some proteins which have the same functions with INPPL1. You can find most of the proteins on our site.
Function | Related Protein |
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SH2 domain binding | NUP62;SHCBP1;SKAP1;PTK2;SH3PXD2B;PAG1;SRC;CRK;SIT1 |
SH3 domain binding | ILK;CBL;DOCK4;EVL;PLSCR3;PTPN22;QKI;NOXA1;DNAJC6 |
actin binding | WASB;CORO1A;ANG;TPM2;KPTN;WASF2;VPS18;DAG1;ADD1 |
hydrolase activity | GALCA;ADAMTS12;PSMB9A;Ces2c;C6AST3;PPAPDC3;MMP1A;CELL;CDADC1 |
inositol-polyphosphate 5-phosphatase activity | INPP5A;INPP5K;INPP5E;INPPL1;INPP5D;INPP5J |
phosphatidylinositol-3,4,5-trisphosphate binding | PHLDA3;INPPL1;ARAP3;ZFYVE16;ASAP1;RS1;NRGN;RACGAP1;CYTH3 |
protein binding | POLE4;TBC1D23;HSD17B8;MRPL20;CROP;INTS3;CEP57L1;ATXN1;DTD2 |
INPPL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with INPPL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of INPPL1.
PTPN1; Sorbs3; Itsn1; Shc1; LRRK1
- Q&As
- Reviews
Q&As (7)
Ask a questionThe INPPL1 protein is encoded by the INPPL1 gene.
INPPL1 plays a key role in regulating insulin signaling and glucose metabolism.
Yes, INPPL1 is known to be involved in lipid metabolism and can affect insulin sensitivity.
Mutations in INPPL1 have been linked to insulin resistance and type 2 diabetes.
The molecular weight of INPPL1 is approximately 135 kDa.
INPPL1 is often referred to as "Inositol Polyphosphate Phosphatase-Like 1."
INPPL1 is mainly found in the cytoplasm and can translocate to the plasma membrane.
Customer Reviews (3)
Write a reviewRemarkable changes in cell behavior were attributed to the potent effects of the product.
Despite its cost, the product's contributions to our research goals made it an invaluable asset.
Our research benefited greatly from the product's ability to induce specific cellular responses, enriching our findings.
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