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ITCH

Official Full Name

itchy E3 ubiquitin protein ligase
Overview

This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein plays a role in multiple cellular processes including erythroid and lymphoid cell differentiation and the regulation of immune responses. Mutations in this gene are a cause of syndromic multisystem autoimmune disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]
Synonyms

ITCH; itchy E3 ubiquitin protein ligase; AIF4; AIP4; NAPP1; dJ468O1.1; E3 ubiquitin-protein ligase Itchy homolog; NFE2-associated polypeptide 1; atrophin-1 interacting protein 4; itchy E3 ubiquitin protein ligase homolog; dJ468O1.1 (atrophin 1 interacting protein 4 (AIP4));

Type

Recombinant Proteins
Cell & Tissue Lysates

Species

Human
Zebrafish

Source

E.coli
HEK293
Mammalian Cell
Wheat Germ

Tag

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	ITCH-3094H	Recombinant Human ITCH protein	E.coli	N/A	Arg526-Glu903	$498 / 20 µg
Human	ITCH-5141HCL	Recombinant Human ITCH 293 Cell Lysate	HEK293	N/A		Inquiry
Human	ITCH-5004H	Recombinant Human ITCH Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	ITCH-01H	Recombinant Human ITCH protein	E.coli			Inquiry
Human	ITCH-1255H	Recombinant Human ITCH protein	E.coli	N/A		Inquiry
Zebrafish	ITCH-8480Z	Recombinant Zebrafish ITCH	Mammalian Cell	His		Inquiry

ITCH involved in several pathways and played different roles in them. We selected most pathways ITCH participated on our site, such as Ubiquitin mediated proteolysis, Endocytosis, TNF signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ITCH were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Ubiquitin mediated proteolysis	FBXO4;MGRN1A;CDC27;PIAS2;UBE2D2L;RHOBTB1;DET1;CDC34A;MDM2
Endocytosis	SH3GL3;ACAP3B;GRK7A;CYTH1;AP2M1B;HLA-A;SH3GLB1B;HLA-B;STAMBPA
TNF signaling pathway	AKT1;TRAF3;MAP3K5;CXCL1;CX3CL1;FOS;RELA;SELE;DNM1L
Non-alcoholic fatty liver disease (NAFLD)	INS1;CASP8;NDUFB7;PIK3CD;PKLR;LEPR;CYCS;UQCRFS1;MAPK9

ITCH has several biochemical functions, for example, CXCR chemokine receptor binding, ligase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ITCH itself. We selected most functions ITCH had, and list some proteins which have the same functions with ITCH. You can find most of the proteins on our site.

Function	Related Protein
CXCR chemokine receptor binding	CXCL20;CXCL12;AMCF-II;CXCL12B;CXCL1;CXCL18B;CXCL6;CXCL5;CXCL12A
ligase activity	MARCH9;GLULA;TRIM21;TRIM32;BIRC2;GLULB;RAD18;SHRPRBCK1R;TTLL2
protein binding	RRAGD;RPL23;TGFB3;GTF3C5;POU1F1;NEDD9;SIRPB1;VAC14;NUDT14
ribonucleoprotein complex binding	SRP54;RNASEL;PRMT7;IFIH1;YBX2;PITX2;SECISBP2;WDR12;TIMM50
ubiquitin protein ligase activity	CBLC;RNF122;CDC34B;UBE2Z;BFAR;ANKIB1;SIAH1A;FANCL;CDC42
ubiquitin-protein transferase activity	TRAF5;FBXO3;RNF146;RC3H2;UBR3;UBE2M;FBXO30A;UBE2W;UBA7

ITCH has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ITCH here. Most of them are supplied by our site. Hope this information will be useful for your research of ITCH.

TP73; SGK3; SNX9; GLI1

Zandberg, DP; Rollins, S; et al. A phase I dose escalation trial of MAGE-A3-and HPV16-specific peptide immunomodulatory vaccines in patients with recurrent/metastatic (RM) squamous cell carcinoma of the head and neck (SCCHN). CANCER IMMUNOLOGY IMMUNOTHERAPY 64:367-379(2015).

Mendling, W; et al. Guideline: Vulvovaginal Candidosis (AWMF 015/072), S2k (excluding chronic mucocutaneous candidosis). MYCOSES 58:1-15(2015).

E3 Ubiquitin Ligases