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ITPR1

Official Full Name

Itpr1 inositol 1,4,5-trisphosphate receptor 1
Synonyms

ITPR1; inositol 1,4,5-trisphosphate receptor 1; inositol 1,4,5-trisphosphate receptor type 1; IP3R 1; insP3R1; IP3 receptor; opisthotonus; InsP3R type I; protein PCD-6; InsP> 3< R type I; type 1 InsP3 receptor; Purkinje cell protein 1; inositol 1,4,5-triphosphate receptor 1; type 1 inositol 1,4,5-trisphosphate receptor; inositol 1,4,5-trisphosphate-binding protein P400; opt; Ip3r; P400; Pcp1; IP3R1; Pcp-1; D6Pas2; InsP3R; Itpr-1; Gm10429; ENSMUSG00000072853;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse

Source

E.coli
HEK293
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
N

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	ITPR1-4945H	Recombinant Human ITPR1 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	ITPR1-2346H	Recombinant Human ITPR1 Protein, His-tagged	E.coli	N-His	Gly112-Val287	Inquiry
Mouse	ITPR1-8389M	Recombinant Mouse ITPR1 Protein	Mammalian Cell	His		Inquiry
Mouse	ITPR1-4655M	Recombinant Mouse ITPR1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	ITPR1-4655M-B	Recombinant Mouse ITPR1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Chicken	ITPR1-4075C	Recombinant Chicken ITPR1	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
ITPR1 Related Articles

ITPR1 involved in several pathways and played different roles in them. We selected most pathways ITPR1 participated on our site, such as Calcium signaling pathway, cGMP-PKG signaling pathway, Phosphatidylinositol signaling system, which may be useful for your reference. Also, other proteins which involved in the same pathway with ITPR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Calcium signaling pathway	SLC8A1;P2RX1;PHKG1A;TACR3L;MYLK;CYSLTR1;ADRB2A;PLCE1;ERBB3A
cGMP-PKG signaling pathway	GNAI1;GATA4;NPR1;PLCB2;INS1;INS;GNA11;AGTR1A;MYH7
Phosphatidylinositol signaling system	IPPK;PRKCBA;CALM;PI4KB;PIP5K1BB;PLCB2;PTEN;PIK3CD;PIP5K2
Oocyte meiosis	PPP1CAA;RPS6KA6;MAD2L2;SMC1B;CPEB3;CALM1;ITPR3;SPDYA;YWHABB
Vascular smooth muscle contraction	CACNA1C;KCNMB2;PRKCQ;AGTR1B;GNA15.1;PLA2G4AA;CALM2B;CALM;ADCY2B
Gap junction	CSNK1DA;TUBA3D;PDGFB;ITPR3;HTR2C;GUCY1A3;GRM5;PLCB4;PDGFD
Platelet activation	PLCB1;APBB1IP;PIK3R3;P2RX1;TLN1;ITGA2B;FGA;VASP;PTGIR
Circadian entrainment	KCNJ6;CAMK2A;GNB4;MAPK1;RPS6KA5;NOS1AP;GNB2;PLCB2;KCNJ9
Long-term potentiation	RAP1B;PPP3CB;PPP1R1A;ITPR1;RPS6KA2;HRAS;CAMK2B;CAMK2A;ATF4
Retrograde endocannabinoid signaling	GNAI1;GRIA3;GABRA6;GABRA4;GNG5;GNG10;PRKCB;RIMS1;GRIA2
Glutamatergic synapse	PRKACG;GRIA4;PPP3CC;GRM5;SLC38A2;ITPR1;SHANK2;Adcy4;PPP3CA
Cholinergic synapse	KCNQ4;HRAS;CHRM2;KCNJ4;CAMK2A;GNAI1;GNAO1;CHRM5;GNG5
Serotonergic synapse	GNB3;PLCB4;HTR1B;SLC6A4;ALOX12E;PRKCB;MAP2K1;GNGT2;HTR2B
Dopaminergic synapse	GRIN2B;ITPR1;CALML3;GNB1;GNAQ;CREB3L3;PPP2R1A;ATF4;CREB3L1
Long-term depression	GUCY1A3;HRAS;RAF1;IGF1;GNA11;BRAF;GRIA3;PLCB2;PRKG2
Inflammatory mediator regulation of TRP channels	TRPV2;PLCG2;ITPR1;PLCB1;ALOX12;IGF1;ASIC3;CYP4A12A;PIK3R2
GnRH signaling pathway	CACNA1SA;MAP2K1;CALM3B;GNAS;MAP3K1;MAPK8A;MMP2;GNAQ;PTK2BB
Estrogen signaling pathway	HSP90AA1;PIK3CD;OPRM1;RAF1;PIK3R3;SHC1;PIK3R5;SHC3;PRKACG
Thyroid hormone synthesis	Adcy4;TG;TPO;ATP1B2;DUOXA2;FXYD2;CANX;GNAS;PRKCB
Oxytocin signaling pathway	PTGS2;CACNB3;PLCB4;CAMKK2;OXTR;PPP1CA;KCNJ14;PRKAG2;PPP1R12C
Renin secretion	CALM3;CALM4;GNAI1;PTGER2;ACE;PPP3CC;AGTR1A;PPP3R1;PRKG2
Aldosterone synthesis and secretion	HSD3B5;AGTR1;SLC14A2;CAMK4;PRKD3;STAR;NPR1;PRKACA;DDX1
Salivary secretion	PRKACA;MUC5B;ATP1A4;PLCB2;ATP1B4;ITPR1;VAMP2;PLCB4;CST1
Gastric acid secretion	PLCB1;ATP4B;ATP1A3;KCNJ2;MYLK3;PRKCB;GNAI3;KCNK2;SST
Pancreatic secretion	CPB1;CPA2;ATP1B1;PLCB3;RYR2;TRPC1;SLC9A1;CLCA3;ATP2B1
Alzheimers disease	PPP3CA;LRP1;MAPT;COX6B1;NDUFB11;PLCB2;IDE;UQCRFS1;APOE
Huntingtons disease	NDUFS3;ATP5O;RCOR1;TFAM;Atp5g2;NDUFA3;DNALC4;COX7C;NDUFS4
Proteoglycans in cancer	PPP1R12A;WNT10B;PRKCA;GPC1;MAPK13;HOXD10;PIK3R5;PPP1R12B;PRKCB

ITPR1 has several biochemical functions, for example, calcium channel activity, calcium channel inhibitor activity, inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ITPR1 itself. We selected most functions ITPR1 had, and list some proteins which have the same functions with ITPR1. You can find most of the proteins on our site.

Function	Related Protein
calcium channel activity	RYR1;TRPC3;CACNA1BA;RYR2;CACNG2B;TMEM37;TRPN1;SLC24A2;SLC24A5
calcium channel inhibitor activity	SLC30A1;AMBP;PHPT1;SLC30A1B;CCDC109B;STX1A;ITPR1;TNNI3;FKBP1AB
inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity	AKR1C1;ITPR3;ITPR2;ITPR1
intracellular ligand-gated calcium channel activity	RYR2;ITPR1;AKR1C1;TRPA1;ITPR3
ion channel activity	KCNF1A;TRPA1A;SCN8AA;ASIC4;FXYD6;KCNC1B;SCN4AA;GJD3;KCNC3B
phosphatidylinositol binding	SLC12A9;SNX7;SEPT12;NOXO1A;ITPR2;PIK3C2G;MTM1;TULP4A;SNX31
protein C-terminus binding	XRCC6;SHANK1;PPM1A;TCF4;HRAS;VPS36;HESX1;TRIM3;PCGF1
protein binding	ATM;NCBP1;ERLIN1;ATF7IP;SNX20;ATL2;RHOA;PIK3C3;OBFC1
protein complex binding	DRD1A;ERCC8;LCA5;DAG1;TRAF2;CCND1;Cel;RAN;RELA
protein phosphatase binding	HSF4;JAK3;MVP;ITPR1;CDKN1B;DLG4;GNB2L1;KCNN4;TRAF3

ITPR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ITPR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ITPR1.

Erp44; Hspa9; Htt; Vdac1; Aco2; Ppif; Hap1; Hap1; PRKACB; HTT; CALM1; Ywhae; Ywhaz

Jarius, S; Scharf, M; et al. Antibodies to the inositol 1,4,5-trisphosphate receptor type 1 (ITPR1) in cerebellar ataxia. Journal of Neuroinflammation 11:-(2014).

Sarachana, T; Hu, VW; et al. Genome-wide identification of transcriptional targets of RORA reveals direct regulation of multiple genes associated with autism spectrum disorder. MOLECULAR AUTISM 4:-(2013).