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ITPR3

Official Full Name

inositol 1,4,5-trisphosphate receptor, type 3
Overview

Inositol 1,4,5-triphosphate receptor, also known as IP3R or InsP3R, is a member of the intracellular calcium release channel family and is located in the endoplasmic reticulum. IP3R functions as a Ca2+ release channel for intracellular stores of calcium i
Synonyms

ITPR3; inositol 1,4,5-trisphosphate receptor, type 3; inositol 1,4,5 triphosphate receptor, type 3; inositol 1,4,5-trisphosphate receptor type 3; IP3R3; insP3R3; IP3 receptor; type 3 InsP3 receptor; inositol 1,4,5-triphosphate receptor, type 3; IP3R; FLJ3;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Rat
Zebrafish

Source

E.coli
HEK293
Mammalian Cell

Tag

His
His (Fc)
Avi
N
GST

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	ITPR3-1701H	Recombinant Human ITPR3 Protein, His&GST-tagged	E.coli	N-His&GST	Phe2389-Asp2496	Inquiry
Mouse	ITPR3-8391M	Recombinant Mouse ITPR3 Protein	Mammalian Cell	His		Inquiry
Mouse	ITPR3-4656M-B	Recombinant Mouse ITPR3 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	ITPR3-4656M	Recombinant Mouse ITPR3 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	ITPR3-3127R	Recombinant Rat ITPR3 Protein	Mammalian Cell	His		Inquiry
Rat	ITPR3-2783R	Recombinant Rat ITPR3 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	ITPR3-2783R-B	Recombinant Rat ITPR3 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	ITPR3-6830Z	Recombinant Zebrafish ITPR3	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
ITPR3 Related Articles

ITPR3 involved in several pathways and played different roles in them. We selected most pathways ITPR3 participated on our site, such as Calcium signaling pathway, cGMP-PKG signaling pathway, Phosphatidylinositol signaling system, which may be useful for your reference. Also, other proteins which involved in the same pathway with ITPR3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Calcium signaling pathway	SLC8A3;LTB4R2;ERBB2;SLC25A4;CAMK2B;ATP2A2B;CAMK2D2;RYR3;STIM1A
cGMP-PKG signaling pathway	CREB3L2;PDE2A;GUCY1B3;MAPK1;VDAC3;PRKCE;MEF2D;AKT2;GNAQ
Phosphatidylinositol signaling system	CALM3B;PLCD1A;INPP4A;PI4K2A;MTMR1A;PIP5K1A;INPP1;PIK3CB;PIK3R3
Oocyte meiosis	ANAPC13;PPP1CC;YWHAE2;PPP1CAA;SPDYB;PLK1;ANAPC5;PPP2R5CB;PPP2R5D
Vascular smooth muscle contraction	PPP1CAA;GUCY1B3;CALD1B;KCNMB1;CACNA1SB;PLA2G3;ITPR3;RHOAD;GNA12A
Gap junction	PRKG2;GRB2;TUBA8L;MAP2K2A;PRKACA;CSNK1DA;GNA15.1;HRAS;TUBA1A
Platelet activation	GP6;F2R;VAMP8;GUCY1B3;COL24A1;PLCB4;PRKACA;PTGIR;TBXAS1
Circadian entrainment	PLCB2;GNGT1;GNAI3;ITPR1;PLCB1;PER3;GNG4;GNG2;RYR2
Long-term potentiation	ARAF;PPP1CA;CALM3;PRKCA;CAMK2B;RPS6KA1;GRIA2;RPS6KA3;RAF1
Retrograde endocannabinoid signaling	SLC17A8;GRIA4;GABRR3;SLC17A7;GRM5;Adcy4;PRKACB;PRKACG;GABRA2
Glutamatergic synapse	SHANK2;GNG10;PRKCB;GRM1;GRIK1;GRIN2C;SHANK3;SLC1A6;GNAO1
Cholinergic synapse	KCNJ4;PRKCA;GNA11;CAMK2B;MAPK1;PLCB1;CHRNB4;PIK3R2;ITPR1
Serotonergic synapse	KCND2;GNG7;GNG2;GNG11;SLC18A2;GNB2;ALOX12E;PLA2G4F;GNG8
Dopaminergic synapse	MAOA;PPP2R2C;SCN1A;GRIA2;PRKACG;COMT;SLC18A1;GNG11;GSK3A
Long-term depression	MAPK1;ARAF;GUCY1B3;PPP1R17;MAP2K1;LYN;RYR1;GRIA3;GRIA2
Taste transduction	TAS1R3;TAS1R1;TAS2R13;PRKACG;TAS2R134;TAS2R118;PRKACB;ITPR3;SCNN1G
Inflammatory mediator regulation of TRP channels	CAMK2A;NTRK1;Adcy4;HTR2A;ACCN3;TRPM8;MAP2K3;HTR2B;IL1B
Insulin secretion	ATP1B1;FFAR1;GNAQ;PLCB4;GPR119;ATP1A3;PRKCB;ATP1A4;GNAS
GnRH signaling pathway	CALML3;MAPK12;PRKACBA;MAP2K6;GNA11B;PRKACG;GRB2B;GNAQ;MAPK7
Estrogen signaling pathway	ATF6B;SHC2;PRKACG;CREB3L2;ITPR1;AKT1;GNAI1;SHC1;PRKACA
Thyroid hormone synthesis	ATP1A2;GPX3;SLC5A5;ITPR3;GNAS;DUOX2;TPO;ATP1B3;GPX6
Oxytocin signaling pathway	GNAQ;CALM1;NPR1;ITPR1;MEF2C;PRKCB;MAPK7;PPP3CC;CALML5
Renin secretion	PPP3CC;ORAI1;CLCA5;PDE1B;PRKG2;PDE1C;PPP3R2;ITPR3;PLCB1
Aldosterone synthesis and secretion	CREB3L1;CREB3L4;LDLR;NPR1;PLCB2;GNA11;ADCY1;PRKCG;PRKD1
Salivary secretion	ATP2B4;PRKACG;ITPR3;TRPV6;LYZ1;CALML3;PLCB1;DMBT1;STATH
Gastric acid secretion	PLCB3;ATP1B2;CCKBR;CALM3;KCNK2;KCNJ10;CAMK2G;CALM4;CAMK2A
Pancreatic secretion	RAB3D;PLA2G12B;ATP2A3;ATP2B4;ATP1A2;ATP2A2;BST1;Slc4a2;TRPC1
Alzheimers disease	PLCB1;NDUFA4;COX8A;ATP2A2;BACE1;APH1C;ERN1;NDUFC2;COX6A2
Proteoglycans in cancer	LUM;AKT2;PPP1R12C;RDX;CBLC;FZD2;PRKACG;PLAU;WNT9A

ITPR3 has several biochemical functions, for example, calcium channel activity, calcium ion binding, inositol 1,3,4,5 tetrakisphosphate binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ITPR3 itself. We selected most functions ITPR3 had, and list some proteins which have the same functions with ITPR3. You can find most of the proteins on our site.

Function	Related Protein
calcium channel activity	TRPC2B;TRPC3;TRPC7A;PSEN1;RYR1B;SLC24A5;TRPC7B;CHRNA10;PKD2L2
calcium ion binding	EFEMP2;GM5077;TMPRSS6;EHD1A;CAPN3;NCAN;LETM1;PPP3R1;F7I
inositol 1,3,4,5 tetrakisphosphate binding	ADAP2;ITPR3;AKR1C1;SYT2;ADAP1
inositol 1,4,5 trisphosphate binding	TRPC6;RPH3A;TRPC2;TRPC1;TRPC3;PLCL1;AKR1C1;TRPC2B;TRPC5A
inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity	ITPR1;ITPR3;AKR1C1;ITPR2
inositol hexakisphosphate binding	AKR1C1;ITPR3
intracellular ligand-gated calcium channel activity	RYR2;ITPR3;ITPR1;AKR1C1;TRPA1
ion channel activity	CLCN1A;CHRNB3B;ASIC4;AKR1C1;GRIN2BB;GRIA3A;CACNA1SA;FXYD5;KCNH1B
phosphatidylinositol binding	ITPR2;SNX18B;SNX17;RPS6KC1;TUB;TNFAIP8L3;ZCCHC2;SNX16;SNX8
protein binding	GCH1;ZNF436;PPP4R2;TBATA;PMS2;RHOT2;SMC3;MAB21L2;NIPAL3

ITPR3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ITPR3 here. Most of them are supplied by our site. Hope this information will be useful for your research of ITPR3.

Abcf1; Lrmp

MARANTO, AR; et al. PRIMARY STRUCTURE, LIGAND-BINDING, AND LOCALIZATION OF THE HUMAN TYPE-3 INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR EXPRESSED IN INTESTINAL EPITHELIUM. JOURNAL OF BIOLOGICAL CHEMISTRY 269:1222-1230(1994).