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ITSN1

Official Full Name

intersectin 1 (SH3 domain protein)
Overview

The protein encoded by this gene is a cytoplasmic membrane-associated protein that indirectly coordinates endocytic membrane traffic with the actin assembly machinery. In addition, the encoded protein may regulate the formation of clathrin-coated vesicles and could be involved in synaptic vesicle recycling. This protein has been shown to interact with dynamin, CDC42, SNAP23, SNAP25, SPIN90, EPS15, EPN1, EPN2, and STN2. Multiple transcript variants encoding different isoforms have been found for this gene, but the full-length nature of only two of them have been characterized so far.
Synonyms

ITSN1; intersectin 1 (SH3 domain protein); ITSN, SH3D1A; intersectin-1; human intersectin SH3 domain containing protein SH3P17; intersectin 1 short form variant 3; intersectin 1 short form variant; 11; intersectin short variant 12; MGC134948; MGC134949; S;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Rat
Zebrafish

Source

E.coli
HEK293
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
His|T7
N

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	ITSN1-28347TH	Recombinant Human ITSN1, His-tagged	E.coli	His		Inquiry
Human	ITSN1-16H	Recombinant Human ITSN1, GST-tagged	Wheat Germ	GST		Inquiry
Mouse	ITSN1-8395M	Recombinant Mouse ITSN1 Protein	Mammalian Cell	His		Inquiry
Mouse	ITSN1-4660M	Recombinant Mouse ITSN1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	Itsn1-1702M	Recombinant Mouse Itsn1 Protein, His-tagged	E.coli	N-His	Met1-Pro151	Inquiry
Mouse	ITSN1-4660M-B	Recombinant Mouse ITSN1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rat	Itsn1-7873R	Recombinant Rat Itsn1 protein, His & T7-tagged	E.coli	His/T7	Met1~Gln227 (Accession # Q9WVE9)	Inquiry
Zebrafish	ITSN1-11829Z	Recombinant Zebrafish ITSN1	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
ITSN1 Related Articles

ITSN1 involved in several pathways and played different roles in them. We selected most pathways ITSN1 participated on our site, such as Axon guidance, Cell death signalling via NRAGE, NRIF and NADE, Developmental Biology, which may be useful for your reference. Also, other proteins which involved in the same pathway with ITSN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Axon guidance	SPNA1;DPYSL5A;KCNQ2;ARPC3;NCK1;PAK7;EFNB1;NRG4;SCN9A
Cell death signalling via NRAGE, NRIF and NADE	ARHGEF1A;FGD2;CASP2;ARHGEF3;OBSCN;ARHGAP4A;AATF;FGD4A;ARHGAP4
Developmental Biology	PEBP1;AP2S1;DUSP4;SMAD3B;NR5A1;EFNA1B;SPAG9;DUSP2;RND1L
EPH-Ephrin signaling	ARPC1A;EFNB1;EPHA4A;EFNB2A;ARPC3;SDCBP;AP2S1;ACTR3;EPHA2A
EPHB forward signaling	ITSN1;EFNB1;GRB7;EFNA5;EFNB3;EFNB2
EPHB-mediated forward signaling	ARPC4;ARHGEF28;CFL1;KALRNB;EFNB2A;EFNB1;EPHB3A;ARPC3;EFNB2
G alpha (12/13) signalling events	AKAP13;ARHGEF16;KALRN;ITSN1;ARHGEF18A;FGD4;ARHGEF1A;ADRA1D;GNA13B
GPCR downstream signaling	QRFPR;PDE10A;CXCL13;ADORA1;RGS19;CHRM1;PNOC;OPN1LW1;LPAR2A

ITSN1 has several biochemical functions, for example, Rho guanyl-nucleotide exchange factor activity, calcium ion binding, guanyl-nucleotide exchange factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ITSN1 itself. We selected most functions ITSN1 had, and list some proteins which have the same functions with ITSN1. You can find most of the proteins on our site.

Function	Related Protein
Rho guanyl-nucleotide exchange factor activity	PLEKHG5;ARHGEF1;ARHGEF1A;PLEKHG2;PREX1;ARHGEF28;ARHGEF1B;ALS2CL;RASGRF2
calcium ion binding	S100A10B;CDH4;LRP2A;PCDHA8;Npnt;CETN1;MCFD2;MYL7;NOTCH3
guanyl-nucleotide exchange factor activity	DOCK11;DOCK6;DENND1C;RAPGEF5B;VAV3B;ARFGEF1;GCGR;RABIF;TBC1D10A
kinase activator activity	TAB1;ITSN1;MOBKL1A
proline-rich region binding	YAP1;ABI2;TCERG1;PRPF40A;CCND1;ITSN1;RABAC1;CSK;APBB1
protein binding	RRAD;SCRIB;VPS26A;MATN2;TPCN2;C1orf21;SETD8;BCL2L10;RBBP5
protein complex scaffold	WWC1;C9orf142;SLC9A3R1;MAGI1;SEPT2;MPP7;TELO2;ISCU;AKAP6

ITSN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ITSN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ITSN1.

CBL; DNM2; WASL

Russo, A; Okur, MN; et al. Phosphatidylinositol 3-kinase, class 2 beta (PI3KC2 beta) isoform contributes to neuroblastoma tumorigenesis. CANCER LETTERS 359:262-268(2015).

Kong, XD; Liu, N; et al. Bioinformatics analysis of biomarkers and transcriptional factor motifs in Down syndrome. BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH 47:834-841(2014).