KALRN
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Official Full Name
kalirin, RhoGEF kinase
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Overview
Huntingtons disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein that interacts with the huntingtin-associated protein 1, which is a huntingtin binding protein that may function in vesicle trafficking. Alternatively spliced transcript variants encoding different isoforms have been described. -
Synonyms
KALRN; kalirin, RhoGEF kinase; HAPIP, huntingtin associated protein interacting protein (duo); kalirin; ARHGEF24; DUET; duo; Hs.8004; serine/threonine kinase with Dbl and pleckstrin homology domains; TRAD; huntingtin-associated protein interacti;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Mouse
- Rat
- HEK293
- Mammalian Cell
- His
- His (Fc)
- Avi
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Mouse | KALRN-8442M | Recombinant Mouse KALRN Protein | Mammalian Cell | His |
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| Mouse | KALRN-4696M-B | Recombinant Mouse KALRN Protein Pre-coupled Magnetic Beads | HEK293 |
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| Mouse | KALRN-4696M | Recombinant Mouse KALRN Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Rat | KALRN-3150R | Recombinant Rat KALRN Protein | Mammalian Cell | His |
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| Rat | KALRN-2806R-B | Recombinant Rat KALRN Protein Pre-coupled Magnetic Beads | HEK293 |
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| Rat | KALRN-2806R | Recombinant Rat KALRN Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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- Involved Pathway
- Protein Function
- Interacting Protein
KALRN involved in several pathways and played different roles in them. We selected most pathways KALRN participated on our site, such as Axon guidance, Cell death signalling via NRAGE, NRIF and NADE, Developmental Biology, which may be useful for your reference. Also, other proteins which involved in the same pathway with KALRN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Axon guidance | KLB;CLASP1;TRPC7;PTPRA;LOC608458;GFRA2;ABL1;PEA15A;FGF8B |
| Cell death signalling via NRAGE, NRIF and NADE | KALRN;BCL2L11;MCF2L;ARHGEF18;FGD4;ITGB3BP;ITSN1;TIAM2;ARHGEF18A |
| Developmental Biology | LGI3;MED20;DRAP1;INSM1A;ACTR2B;TRPC5;CFC1;CNKSR1;EPHB4B |
| EPH-Ephrin signaling | EPHA2A;ARPC4;MYL12A;ITSN1;AP2B1;EFNA5;EFNA1;ARPC1B;EPHA2 |
| EPHB-mediated forward signaling | CFL1;EFNB2;ARHGEF28;EPHB4A;ACTR2;KALRNB;ARPC3;EFNB1;ARPC5 |
| G alpha (12/13) signalling events | ECT2;NET1;ADRA1B;ARHGEF3;ARHGEF1A;ITSN1;TRIO;KALRNB;ADRA1D |
| G alpha (q) signalling events | ARHGEF25;CHRM1;AGT;KISS1;LPAR5A;CCK;LTB4R;GCGB;ABHD12 |
| GPCR downstream signaling | SSTR2;LPAR1;SST1.1;OR56A1;OR52B4;TAS2R7;ARHGEF17;CRHR1;ADRA2C |
KALRN has several biochemical functions, for example, ATP binding, Rho guanyl-nucleotide exchange factor activity, enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KALRN itself. We selected most functions KALRN had, and list some proteins which have the same functions with KALRN. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | FPGS;EHD2;HSPA4A;PRKY;ACTA1A;UBE2KA;NLRP1;RAD51B;CFTR |
| Rho guanyl-nucleotide exchange factor activity | FARP2;MCF2L;ARHGEF37;PLEKHG2;AKAP13;ARHGEF1A;ARHGEF17;TRIO;ARHGEF25 |
| enzyme binding | Il6ra;PTPLAD2;Ar;DDC;EIF4E;AKIRIN2;PICK1;C2orf56;BRCA1 |
| guanyl-nucleotide exchange factor activity | SERGEF;TIAM2;DOCK6;RASGRP3;PTGIR;DOCK5;SH2D3A;DOCK4;DENND6A |
| kinase activity | NME2A;MARCKSB;CSNK1G2A;PHKG1A;CAMK1DA;PRKACBA;PPM1E;KALRN;PTK2BB |
| metal ion binding | CYP4F18;ZRSR2;CD209B;TANK;NAIP6;ENTPD7;NUBPL;Scd2;BTR12 |
| nucleotide binding | CNGA4;ZCRB1;CLK2B;DCLK1A;ERBB3B;DCKL1B;MYO10;PKM;LTB4R |
| protein kinase activity | EPHA4A;MAP4K3;PAK2;FGFR1B;LIMK1A;AKT2L;EIF2AK2;PRKG2;DAPK1 |
| protein serine/threonine kinase activity | STK38L;ICK;DYRK1A;DYRK4;SRPK1B;Aatk;CLK3;PRKACBA;MAPKAPK5 |
| transferase activity | AGPAT9L;MAP3K12;Acnat1;MAPK14B;PRKACBB;EPHB4A;CDYL;PIK3R3B;UAP1L1 |
KALRN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KALRN here. Most of them are supplied by our site. Hope this information will be useful for your research of KALRN.
HAP1; Sncaip; Grin1; Grin2b; Dlg4; Ywhab
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