MGLL
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Official Full Name
Mgll monoglyceride lipase
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Overview
This gene encodes a serine hydrolase of the AB hydrolase superfamily that catalyzes the conversion of;monoacylglycerides to free fatty acids and glycerol. The encoded protein plays a critical role in several;physiological processes including pain and nociperception through hydrolysis of the endocannabinoid;2-arachidonoylglycerol. Expression of this gene may play a role in cancer tumorigenesis and metastasis. Alternatively;spliced transcript variants encoding multiple isoforms have been observed for this gene. -
Synonyms
MGLL; monoglyceride lipase; monoacylglycerol lipase; Mgl; Magl; AA589436;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Yeast
- Flag
- GST
- His
- His (Fc)
- Avi
- His|SUMO
- Myc
- DDK
- N/A
- N
- No tag
- T7
- Involved Pathway
- Protein Function
- Interacting Protein
- MGLL Related Articles
- MGLL Related Research Area
MGLL involved in several pathways and played different roles in them. We selected most pathways MGLL participated on our site, such as Acyl chain remodeling of DAG and TAG, Arachidonate production from DAG, Effects of PIP2 hydrolysis, which may be useful for your reference. Also, other proteins which involved in the same pathway with MGLL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
---|---|
Acyl chain remodeling of DAG and TAG | AWAT1;DGAT1B;AWAT2;MGLL |
Arachidonate production from DAG | ABHD12;ABHD6B;MGLL |
Effects of PIP2 hydrolysis | TRPC3;TRPC7;TAE1;DGKG;DGKB;ABHD6B;RASGRP2;DGKQ;PRKCHB |
G alpha (q) signalling events | RASGRP2;LPAR2A;RGS19;EDN2;PROKR1;ANXA1A;PROKR1A;GRP;TAE1 |
GPCR downstream signaling | PTGDR2;OR7D2;S1PR1;RLN3A;ARHGEF17;S1PR5B;CCR9;NMUR1;RGS7 |
Gastrin-CREB signalling pathway via PKC and MAPK | HCRT;GPR4;NTS;FPR-RS3;GPR132;PROKR1;NMS;GPR65;NMBA |
Glycerolipid metabolism | LIPF;ALDH2;DGKQ;DGKZ;LPIN2;TAE1;PPAP2C;AGPAT3;AGPAT2 |
Glycerophospholipid biosynthesis | PLBD1;BCHE;CPNE1;PLA2G16;GPAT2;PLD6;CHKB;PLD4;DGAT1B |
MGLL has several biochemical functions, for example, acylglycerol lipase activity, lysophospholipase activity, protein homodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MGLL itself. We selected most functions MGLL had, and list some proteins which have the same functions with MGLL. You can find most of the proteins on our site.
Function | Related Protein |
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acylglycerol lipase activity | ABHD12;PNLIPRP2;FAAH;MGLL;ABHD6 |
lysophospholipase activity | PNPLA7A;MGLL;PNPLA7;PLA2G4F;LYPLA1;PLB1;PLA2G4AA;ASPG;ENPP2 |
protein homodimerization activity | DMRT3A;CRYBB2;NOD1;CPNE1;PTS;UGT1A9;ANO2;MTUS2;FASN |
MGLL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MGLL here. Most of them are supplied by our site. Hope this information will be useful for your research of MGLL.
CHGB; mdtI; q5ngv3_fratt
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