MFGE8
-
Official Full Name
milk fat globule-EGF factor 8 protein
-
Overview
Apoptotic cells are rapidly removed by phagocytosis to clear the living cells and tissues of intracellular materials being released from dying cells. Phagocytes recognize apoptotic cells through milk fat globule-EGF-factor 8 (MFG-E8). MFG-E8 is a secreted -
Synonyms
MFGE8; milk fat globule-EGF factor 8 protein; lactadherin; MP47; EGF/factor VIII; sperm surface protein SP47; milk fat globule glycoprotein; P47; Mfgm; SED1; MFG-E8; AA408458; AI325141;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Native Proteins
- Bovine
- Chicken
- Cynomolgus Monkey
- Human
- Mouse
- Rat
- Bovine
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Insect Cell
- Insect Cells
- Mammalian Cell
- Mammalian cells
- Milk, also secreted by stimulated macrophages, vascular smooth muscle, endothelial cells
- Wheat Germ
- C
- His
- Myc
- DDK
- GST
- His (Fc)
- Avi
- His|Avi
- His|GST
- His|SUMO
- Myc|DDK
- N/A
- N
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
---|---|---|---|---|---|---|
Human | MFGE8-408H | Active Recombinant Human MFGE8, His-tagged | Mammalian cells | His | ||
Human | MFGE8-587H | Active Recombinant Human MFGE8 protein, His-tagged | Insect Cells | His | Met1-Cys387 | |
Human | MFGE8-422HCL | Recombinant Human MFGE8 cell lysate | Insect Cell | N/A | ||
Human | MFGE8-220H | Recombinant Human MFGE8 Protein, MYC/DDK-tagged, C13 and N15-labeled | HEK293 | C-Myc/DDK | ||
Human | MFGE8-652H | Recombinant Human MFGE8 Protein (24-387 aa), His-SUMO-tagged | E.coli | His/SUMO | 24-387 aa | |
Human | MFGE8-445H | Recombinant Human MFGE8 Protein (Met1-Cys387), His-AVI-tagged, Biotinylated | Insect Cell | His/Avi | Met1-Cys387 | |
Human | MFGE8-4543H | Recombinant Human MFGE8 Protein (Met1-Cys335), N-His tagged | E.coli | N-His | Met1-Cys335 | |
Human | MFGE8-3466H | Recombinant Human MFGE8 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Human | MFGE8-4542H | Recombinant Human MFGE8 Protein (Met1-Lys239, Trp137-Cys387), C-His tagged | E.coli | C-His | Met1-Lys239, Trp137-Cys387 | |
Human | MFGE8-3466H-B | Recombinant Human MFGE8 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Human | MFGE8-4544H | Recombinant Human MFGE8 Protein (Leu24-Cys387), N-His tagged | E.coli | N-His | Leu24-Cys387 | |
Human | MFGE8-4385H | Recombinant Human MFGE8 Protein, GST-tagged | Wheat Germ | GST | ||
Human | MFGE8-1242H | Recombinant Human MFGE8 Protein, MYC/DDK-tagged | HEK293 | Myc/DDK | ||
Human | MFGE8-1775H | Recombinant Human MFGE8 Protein, His&GST-tagged | E.coli | N-His&GST | His65-Ile302 | |
Human | MFGE8-6195HF | Recombinant Full Length Human MFGE8 Protein, GST-tagged | In Vitro Cell Free System | GST | 387 amino acids | |
Mouse | Mfge8-407M | Active Recombinant Mouse Mfge8, His-tagged | Mammalian cells | His | ||
Mouse | Mfge8-6768M | Recombinant Mouse Mfge8 protein, His-tagged | E.coli | His | Ile159~Ser417 (Accession # P21956) | |
Mouse | Mfge8-4056M | Recombinant Mouse Mfge8 Protein, Myc/DDK-tagged | HEK293T | Myc/DDK | ||
Mouse | Mfge8-5514M-B | Recombinant Mouse Mfge8 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Mouse | Mfge8-5514M | Recombinant Mouse Mfge8 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Rat | Mfge8-6769R | Recombinant Rat Mfge8 protein, His & GST-tagged | E.coli | His/GST | Cys73~Arg421 (Accession # P70490) | |
Bovine | MFGE8-8518B | Native Bovine MFGE8, Fluoresence-labeled | Bovine | N/A | ||
Bovine | MFGE8-288B | Native Bovine Lactadherin | Milk, also secreted by stimulated macrophages, vascular smooth muscle, endothelial cells | N/A | ||
Bovine | MFGE8-289B | Native MFG-E8 | Milk, also secreted by stimulated macrophages, vascular smooth muscle, endothelial cells | N/A | ||
Cynomolgus Monkey | MFGE8-688C | Recombinant Cynomolgus MFGE8 Protein, His-tagged | Mammalian Cell | His | ||
Cynomolgus Monkey | MFGE8-434C | Recombinant Cynomolgus Monkey MFGE8 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Cynomolgus Monkey | MFGE8-434C-B | Recombinant Cynomolgus Monkey MFGE8 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Chicken | MFGE8-4726C | Recombinant Chicken MFGE8 | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
- MFGE8 Related Articles
- MFGE8 Related Research Area
MFGE8 involved in several pathways and played different roles in them. We selected most pathways MFGE8 participated on our site, such as Amyloid formation, Integrins in angiogenesis, Metabolism of proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with MFGE8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
---|---|
Amyloid formation | CST3;TTR;LTF;NAT8B;HIST3H2BB;APCS;HIST4H4;ODAM;TGFBI |
Integrins in angiogenesis | MFGE8;CSF1R;CSF1;EDIL3;ANGPTL3 |
Metabolism of proteins | ARSE;IGFBP2B;GALNT13;ADAMTS20;NAPG;BET1;FKBP9;DPH5;SEC63 |
MFGE8 has several biochemical functions, for example, integrin binding, phosphatidylethanolamine binding, phosphatidylserine binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MFGE8 itself. We selected most functions MFGE8 had, and list some proteins which have the same functions with MFGE8. You can find most of the proteins on our site.
Function | Related Protein |
---|---|
integrin binding | EGFL6;ICAM3;LAMB1;COL3A1;ADAM25;ESM1;DMP1;ADAM10;CIB2 |
phosphatidylethanolamine binding | NF1;ESYT2;ANXA11;CD300A;PEMT;LC3;MFGE8;PEBP1 |
phosphatidylserine binding | JPH2;SYT4;CD300A;SCARB1;RPE65;MARK1;OSBPL8;ANXA9;PLCD1 |
MFGE8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MFGE8 here. Most of them are supplied by our site. Hope this information will be useful for your research of MFGE8.
MYC
- Q&As
- Reviews
Q&As (6)
Ask a questionThe structure of MFGE8 determines its ability and stability to bind to other proteins. The study of its structure can help us understand its function and mechanism of action.
MFGE8 can interact with a variety of other proteins, including Caspase-3, Caspase-8, EGFR, etc. These interactions enable it to regulate processes such as apoptosis, signal transduction, and cell adhesion.
Future studies of MFGE8 may focus on the following aspects: its structure-function relationship, mechanisms of interaction with other proteins, regulatory mechanisms in cells, and potential therapeutic applications. At the same time, the study of MFGE8's interaction with specific signal transduction pathways and its regulatory effect on cell growth and differentiation will also become one of the future research priorities.
Therapeutic strategies for MFGE8 may include regulating its expression level, inhibiting its interaction with other proteins, and promoting or inhibiting its function. These methods may have potential applications in the treatment of cancer, neurodegenerative diseases, and autoimmune diseases.
In neurodegenerative diseases, MFGE8 may influence the survival and death processes of neurons by regulating apoptosis and signal transduction. It could be a potential target for the treatment of neurodegenerative diseases.
Drug development against MFGE8 needs to consider its specificity, safety, pharmacokinetic properties, and potential side effects. In addition, issues such as the dosage form, route of administration and design of clinical trials need to be considered.
Customer Reviews (3)
Write a reviewIt has high application effect and safety in clinical treatment.
MFGE8 has a high resolution in Western blots, which can distinguish similar protein molecular weights.
Good stability and activity retention during long-term storage.
Ask a Question for All MFGE8 Products
Required fields are marked with *
My Review for All MFGE8 Products
Required fields are marked with *