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NCOA4

Official Full Name

nuclear receptor coactivator 4
Overview

This gene encodes an androgen receptor coactivator. The encoded protein interacts with the androgen receptor in a ligand-dependent manner to enhance its transcriptional activity. Chromosomal translocations between this gene and the ret tyrosine kinase gene, also located on chromosome 10, have been associated with papillary thyroid carcinoma. Alternatively spliced transcript variants have been described. Pseudogenes are present on chromosomes 4, 5, 10, and 14.
Synonyms

NCOA4; nuclear receptor coactivator 4; ARA70; DKFZp762E1112; ELE1; PTC3; RET activating gene ELE1; RFG; NCoA-4; ret fused; 70 kDa AR-activator; RET-activating gene ELE1; 70 kDa androgen receptor coactivator; androgen receptor-associated protein of 70 kDa;

Type

Recombinant Proteins
Cell & Tissue Lysates

Species

Chicken
Human
Mouse
Zebrafish

Source

E.coli
HEK293
HEK293T
Mammalian Cell

Tag

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	NCOA4-1214H	Recombinant Human NCOA4, His-tagged	E.coli	His	N-term-400aa	$319 / 25ug
Human	NCOA4-3940HCL	Recombinant Human NCOA4 293 Cell Lysate	HEK293	N/A		Inquiry
Human	NCOA4-423H	Recombinant Human NCOA4 Protein, MYC/DDK-tagged, C13 and N15-labeled	HEK293	C-Myc/DDK		Inquiry
Mouse	Ncoa4-4315M	Recombinant Mouse Ncoa4 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry
Zebrafish	NCOA4-11351Z	Recombinant Zebrafish NCOA4	Mammalian Cell	His		Inquiry
Chicken	NCOA4-1634C	Recombinant Chicken NCOA4	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
NCOA4 Related Articles

NCOA4 involved in several pathways and played different roles in them. We selected most pathways NCOA4 participated on our site, such as Pathways in cancer, Thyroid cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with NCOA4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Pathways in cancer	WNT8B;FGF4;PDGFRA;PTK2;WNT11;WNT1;MAPK3;MITF;FGF11
Thyroid cancer	LEF1;PAX8;MAP2K1;MAP2K2;RXRG;MAPK1;KRAS;RXRB;TP53

NCOA4 has several biochemical functions, for example, androgen receptor binding, transcription coactivator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NCOA4 itself. We selected most functions NCOA4 had, and list some proteins which have the same functions with NCOA4. You can find most of the proteins on our site.

Function	Related Protein
androgen receptor binding	NCOA1;TCF21;CALR;PRPF6;NCOA4;RB1;PRKCBB;TGFB1I1;FOXH1
transcription coactivator activity	GTF2A2;RAP2C;ATXN7L3;CITED4;SUB1B;SUB1A;BRD7;ESR2;YAP1

NCOA4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NCOA4 here. Most of them are supplied by our site. Hope this information will be useful for your research of NCOA4.

AR; AKT1; q81sn0_bacan; spoIVA; ATXN2; PSMD14; PSMC1; USP43; Psmd6

Harada, K; Kakuda, Y; et al. Alteration of energy metabolism in the pathogenesis of bile duct lesions in primary biliary cirrhosis. JOURNAL OF CLINICAL PATHOLOGY 67:396-402(2014).

Chien, CD; Kirilyuk, A; et al. Role of the Nuclear Receptor Coactivator AIB1-Delta 4 Splice Variant in the Control of Gene Transcription. JOURNAL OF BIOLOGICAL CHEMISTRY 286:26813-26827(2011).