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NHLRC1

Official Full Name

NHL repeat containing 1
Overview

The protein encoded by this gene is a single subunit E3 ubiquitin ligase. Laforin is polyubiquitinated by the encoded;protein. Defects in this intronless gene lead to an accumulation of laforin and onset of Lafora disease, also known as;progressive myoclonic epilepsy type 2 (EPM2).
Synonyms

NHLRC1; NHL repeat containing 1; E3 ubiquitin-protein ligase NHLRC1; bA204B7.2; epilepsy; progressive myoclonus type 2B; EPM2B; malin; MGC119265; EPM2A; MGC119262; MGC119264; NHL repeat containing protein 1; NHL repeat-containing protein 1; NHLC1_HUMAN; NHLRC 1;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	NHLRC1-1291H	Recombinant Human NHLRC1, GST-tagged	E.coli	GST	C-310aa	$319 / 25ug
Human	NHLRC1-30H	Recombinant Human NHLRC1 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Rat	NHLRC1-3984R	Recombinant Rat NHLRC1 Protein	Mammalian Cell	His		Inquiry
Rat	NHLRC1-3643R	Recombinant Rat NHLRC1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	NHLRC1-3643R-B	Recombinant Rat NHLRC1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry

Involved Pathway
Protein Function
Interacting Protein
NHLRC1 Related Articles

NHLRC1 involved in several pathways and played different roles in them. We selected most pathways NHLRC1 participated on our site, such as Glucose metabolism, Glycogen synthesis, Metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with NHLRC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Glucose metabolism	AGL;SLC25A1A;PYGMB;GYG2;GYG1B;SLC25A11;EPM2A;SLC25A10;GYG1
Glycogen synthesis	GYG1B;NHLRC1;GYG1A;EPM2A
Metabolism	PLIN2;ACOT12;KCNS3;DGUOK;AGPAT6;ACSF3;GPAT2;UGT1B3;NFYBA
Metabolism of carbohydrates	OXSR1;MAPK1IP1L;B3GNT2;SLC25A12;HPSE;GLB1L;EPM2A;SLC25A11;CHP
Ubiquitin mediated proteolysis	UBOX5;SIAH2L;UBE2G1B;UBE2E1;COP1;UBE2U;SIAH1;ANAPC5;FLJ11011L

NHLRC1 has several biochemical functions, for example, ligase activity, protein binding, ubiquitin protein ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NHLRC1 itself. We selected most functions NHLRC1 had, and list some proteins which have the same functions with NHLRC1. You can find most of the proteins on our site.

Function	Related Protein
ligase activity	NAPRT;RNF180;MUL1A;HECW2;KCNG4;PCXB;MKRN3;RNF25;MARCH1
protein binding	PBX1;MARVELD2;PHC2;PACSIN3;COL3A1;ZFP143;CASK;ATP11C;IFT46
ubiquitin protein ligase activity	TMEM189;MED17;RNF152;MSL2A;ANKIB1;NEDD4;RNF41;TRIM3;TRIM59
ubiquitin-protein transferase activity	UBE3A;LTN1;FBXO21;TRIM37;UHRF2;UBE2Q2;FBXL3;TRAF7;UBE2E3
zinc ion binding	PPARAA;RFFL;SUPT4H1;RNF133;CNOT4;TRIM22;ZFAND3;ZDHHC18;C11orf54

NHLRC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NHLRC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NHLRC1.

EPM2A; Epm2a; HSP90AB1

Smith, JA; Lovley, DR; et al. Outer Cell Surface Components Essential for Fe(III) Oxide Reduction by Geobacter metallireducens. APPLIED AND ENVIRONMENTAL MICROBIOLOGY 79:901-907(2013).

Brackmann, FA; Kiefer, A; et al. Rapidly Progressive Phenotype of Lafora Disease Associated With a Novel NHLRC1 Mutation. PEDIATRIC NEUROLOGY 44:475-477(2011).