NKX3-1
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Official Full Name
NK3 homeobox 1
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Overview
The Nkx3.1 gene is an androgen regulated prostate-specific homeobox gene, located on chromosome 8p21. In mice the homologue Nkx3.1 is exclusively expressed in prostate epithelium. In humans, Nkx3.1 expression is also restricted to the prostate. Many data show that Nkx3.1 expression is highly, but not exclusively, specific for the prostate. -
Synonyms
NKX3-1; NK3 homeobox 1; NK homeobox (Drosophila), family 3, A , NK3 transcription factor related, locus 1 (Drosophila) , NKX3A; homeobox protein Nkx-3.1; BAPX2; NKX3.1; NK homeobox, family 3, A; homeobox protein NK-3 homolog A; NK3 transcription factor homolog A; NK3 transcription factor related, locus 1; NKX3; NKX3A;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rhesus Macaque
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- NKX3-1 Related Articles
- NKX3-1 Related Research Area
NKX3-1 involved in several pathways and played different roles in them. We selected most pathways NKX3-1 participated on our site, such as Pathways in cancer, Prostate cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with NKX3-1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Pathways in cancer | GNGT1;RASSF5;GNG4;BCL2L1;AXIN1;KRAS;FGF13;GNA12;ABL1 |
Prostate cancer | PDGFD;PIK3R1;TCF7L2;NFKB1;NDRG1;GSK3B;MTOR;FOXO1;CREB5 |
NKX3-1 has several biochemical functions, for example, DNA binding, MADS box domain binding, androgen receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NKX3-1 itself. We selected most functions NKX3-1 had, and list some proteins which have the same functions with NKX3-1. You can find most of the proteins on our site.
Function | Related Protein |
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DNA binding | ZFP191;NKX1.2LB;ZEB1B;GTF2A1L;HOXD13;PBX3B;HNF4A;DDX3X;CAMTA1 |
MADS box domain binding | NKX3-1;NKX3 |
androgen receptor activity | NKX3-1;Ar;NR1I3;NKX3 |
core promoter binding | NOTCH1;SFPQ;IFI16;TFAP2C;RB1;ARNTL;NKX3-1;PSPC1;CLOCK |
contributes_to cysteine-type endopeptidase activator activity involved in apoptotic process | CDKN1B;NKX3;NKX3-1 |
estrogen receptor activity | ESR2;GPR30;ESR2A;ESR1;NKX3;NKX3-1;LEF1;ESR2B |
estrogen receptor binding | TRIP4;NRIP1;NKX3-1;DDX17;CCDC62;ARRB1;TAF10;PPARG;NSD1 |
histone deacetylase binding | PHB;HIC1;DNMT3B;YWHAB;MAGEA1;MEF2A;KPNA2;HIF1A;CDC20 |
protein binding | CPS1;ABLIM1;AKR1A1;LDLR;FOXK1;CDC5L;STAT6;FRAG1;GDI1 |
protein kinase activator activity | GPRC5B;PRKAG2;STK11;CAB39;MT3;DBF4B;DAXX;MAPK8IP2;EPO |
protein self-association | PCSK9;AGXT;AXIN1;S100A7A;TRIM32;AGTR1A;MDH2;DYRK1A;ZFP639 |
sequence-specific DNA binding | SATB1A;HOXB8A;PRDM16;WT1;DLX6A;FOXJ1A;TRP53;HOXA3;THRAA |
contributes_to transcription factor activity, RNA polymerase II core promoter sequence-specific | NKX3-1;SRF |
transcription factor activity, sequence-specific DNA binding | PDX1;EGR3;CREB5;HOXB3;BSX;PRRX2;GPBP1;BACH1A;GATA1A |
transcription factor binding | TBL1X;ERCC3;PIANP;TCF12;PER1;SMAD2;LEF1;SIRT2;SNF8 |
transcription regulatory region DNA binding | TRP53;BRD7;NCOR1;TOMM20A;TCF7;XRCC5;SP1;RFX3;CTCFL |
transcription regulatory region sequence-specific DNA binding | GATA1;EGR1;ARNTL1A;ARNTL;NFE2L2A;NR5A5;NKX3-1;SOX2;BACH1B |
NKX3-1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NKX3-1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NKX3-1.
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