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NPAS2

Official Full Name

neuronal PAS domain protein 2
Overview

The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH)-PAS family of transcription factors. A similar mouse protein may play a regulatory role in the acquisition of specific types of memory. It also may function as a part of a molecular clock operative in the mammalian forebrain.
Synonyms

NPAS2; neuronal PAS domain protein 2; neuronal PAS domain-containing protein 2; bHLHe9; MOP4; PASD4; Basic helix loop helix PAS protein MOP4; Basic-helix-loop-helix-PAS protein MOP4; Class E basic helix-loop-helix protein 9; FLJ23138; Member of PAS protein 4; Member of PAS superfamily 4; MGC71151; Neuronal PAS domain containing protein 2; Neuronal PAS2; NPAS2_HUMAN; PAS domain-containing protein 4; OTTHUMP00000161260;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	NPAS2-1208HCL	Recombinant Human NPAS2 cell lysate		N/A		Inquiry
Human	NPAS2-6015H	Recombinant Human NPAS2 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	NPAS2-6606HF	Recombinant Full Length Human NPAS2 Protein, GST-tagged	In Vitro Cell Free System	GST	824 amino acids	Inquiry
Zebrafish	NPAS2-9595Z	Recombinant Zebrafish NPAS2	Mammalian Cell	His		Inquiry
Chicken	NPAS2-2256C	Recombinant Chicken NPAS2	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein

NPAS2 involved in several pathways and played different roles in them. We selected most pathways NPAS2 participated on our site, such as Circadian rhythm, which may be useful for your reference. Also, other proteins which involved in the same pathway with NPAS2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Circadian rhythm	RORB;PRKAG3;PER1;RBX1;PRKAA1;PRKAB2;FBXW11;SKP1;PRKAB1

NPAS2 has several biochemical functions, for example, DNA binding, Hsp90 protein binding, core promoter binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NPAS2 itself. We selected most functions NPAS2 had, and list some proteins which have the same functions with NPAS2. You can find most of the proteins on our site.

Function	Related Protein
DNA binding	TIGD6;MXTX1;ZNF624;FOXD5;ZNF184;HIST1H4I;CHD1;TADA2B;Arid4b
Hsp90 protein binding	NASP;UNC45A;GBP1;FKBP6;PACRG;CSNK2A1;ERN1;HIF1A;CDC37
core promoter binding	ELK4;E2F3;REST;INSM1B;E2F1;HDAC6;NKX3;GTF2B;RELB
metal ion binding	ASGR1;ZFYVE21;NME7;GNE;ZFP827;ZNF830;CYP2J6;MYO9B;LHX2B
protein binding	PSMB9;BAHD1;FAM122A;KPNA2;GDI2;CHERP;ARL4A;ERP27;SYTL4
protein dimerization activity	SIM1B;HPSE;SREBF1;HES2;AHRRB;HIF1AB;ATOH1B;ANO7;HEY1
transcription factor activity, sequence-specific DNA binding	GATA2;ZNF234;DRAP1;RORAB;NFYA;NFE2L3;CARF;NEUROD1;INSM1B

NPAS2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NPAS2 here. Most of them are supplied by our site. Hope this information will be useful for your research of NPAS2.

Clock; BHLHE40; RORC; CSNK2B; Cry1; RPL6; Cry2; Arntl