NRAS
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Official Full Name
neuroblastoma RAS viral (v-ras) oncogene homolog
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Overview
This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in this gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia -
Synonyms
NRAS; neuroblastoma RAS viral (v-ras) oncogene homolog; GTPase NRas; N ras; N-ras protein part 4; transforming protein N-Ras; v-ras neuroblastoma RAS viral oncogene homolog; NS6; ALPS4; N-ras; NRAS1;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Cynomolgus Monkey
- Human
- Mouse
- Rat
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- Bacterial expression system
- E.coli
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- Mammalian cells
- Wheat Germ
- biotinylated
- Flag
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- Myc|DDK
- N/A
- No tag
- Involved Pathway
- Protein Function
- Interacting Protein
- NRAS Related Articles
- NRAS Related Research Area
- NRAS Related Signal Pathway
NRAS involved in several pathways and played different roles in them. We selected most pathways NRAS participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with NRAS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| MAPK signaling pathway | HSPA8;HSP70L;FGF13A;ZAK;MAP3K3;NLK2;CASP3B;STMN1B;PDGFB |
| ErbB signaling pathway | MAPK8B;HRASB;EREG;PIK3CD;PIK3CG;RPS6KB2;PRKCB;ERBB3A;STAT5A |
| Ras signaling pathway | PLA2G1B;FASLG;RASGRP3;ARF6;PLA2G2A;VEGFA;NGF;FGF14;GAB2 |
| Rap signaling pathway | VASP;BCAR1;INS;GRIN2A;FGF17;IGF1R;RAPGEF6;CALM3;SIPA1L1 |
| Chemokine signaling pathway | XCL1;Ccl9;CRKL;CCL28;SHC3;RAC2;CCR9;NFKBIB;CCL8 |
| FoxO signaling pathway | PRKAB1A;PLK1;SMAD4;RAG1;GABARAP;PLK2B;PIK3R5;CCNB2;S1PR1 |
| Sphingolipid signaling pathway | PLCB3;PPP2R1B;LASS4;PPP2R2C;SGPP1;SPTLC2;MAPK3;LASS2;SMPD2 |
| Phospholipase D signaling pathway | PRKCA;PPAP2A;Kitl;PTGFR;AVPR1A;LPAR2;DGKE;AKT2;PIK3CA |
| PIK-Akt signaling pathway | IGF1R;FOXO3;ITGA9;FGF4;IL7R;ITGA5;IFNA14;PPP2R3C;PPP2R5C |
| Axon guidance | ROBO2;FGF20A;ITSN1;CLTC;SEMA3E;FGF18B;CXCL12;SLC14A2;PLXNB2 |
| VEGF signaling pathway | PIK3CD;MAPK11;PIK3R3;RAC1;SHC2;PIK3R3A;NOS3;AKT2;RAC3B |
| Tight junction | CLDN10A;CDC42L2;PRKCDA;MAGI2;RHOAB;PPP2CB;CLDN1;ACTN3;VAPAL |
| Gap junction | GRM5;TUBA3D;HTR2C;TUBA8L3;PLCB2;TUBA3A;RAF1A;HTR2A;GJD2 |
| Signaling pathways regulating pluripotency of stem cells | FZD3;KRAS;WNT7A;ZIC3;FZD6;ID4;IL6ST;HRAS;ISL1 |
| Natural killer cell mediated cytotoxicity | MAP2K1;IFNAR1;KLRC1;ITGB2;PIK3R2;KIR2DL1;TNFSF10;RAET1E;NCR2 |
| T cell receptor signaling pathway | PPP3CB;RELA;GRAPA;CD4;PPP3R1;NFKBIB;PPP3R2;CBLB;PIK3CD |
| B cell receptor signaling pathway | NFKBIA;cgr2b;CD81;ITPR2;TTC6;GSK3B;PTPN18;LCP2A;MAP2K1 |
| Fc epsilon RI signaling pathway | IL5;PLCG2;MAPK9;PLA2G4B;GRB2;KRAS;GM-CSF;MAPK8;RAC2 |
| Long-term potentiation | CALM1;PRKCG;GRIN2C;PLCB4;ATF4;RAP1A;MAP2K2;PRKCB;PRKCA |
| Neurotrophin signaling pathway | RPS6KA3;RPS6KA6;SHC3;GSK3B;PIK3CG;KRAS;SHC1;ARHGDIG;ARHGDIB |
| Cholinergic synapse | PLCB1;PRKCG;CHRNA3;PIK3CG;GNB4;ACHE;PRKCA;HRAS;PIK3R3 |
| Serotonergic synapse | GNAS;CYP2C39;GNG4;ALOX15;GNB3;ARAF;PRKACB;PLA2G4D;PLCB1 |
| Long-term depression | PPP2R1A;MAP2K2;HRAS;CRH;PLA2G4D;KRAS;PRKCB;GNAI2;LYN |
| Regulation of actin cytoskeleton | F2R;VAV2;BCAR1;PXNA;ITGB1B.2;MAP2K2B;ITGA2;PIP5K1B;ACTB2 |
| Insulin signaling pathway | PIK3CA;PRKAA2;CALM3;HKDC1;AKT3A;MAPK8A;FLOT2A;PPP1R3CA;SHC3 |
| GnRH signaling pathway | PRKACA;HBEGFA;CACNA1SA;CDC42L;MAPK12B;GNA11;MAP2K4A;MMP14A;MAPK11 |
| Estrogen signaling pathway | HSPA8;SHC4;AKT2;PIK3R1;PIK3R5;MMP2;CALML5;ITPR1;PIK3CD |
| Melanogenesis | FZD8B;WNT4A;GNAO1A;PLCB3;WNT3A;EP300;FZD9;WNT2B;GNAS |
| Prolactin signaling pathway | SOCS5;SOCS1;GALT;AKT1;SHC3;PIK3CA;MAP2K1;PIK3R3;SOCS4 |
| Thyroid hormone signaling pathway | MED27;RCAN2;HDAC3;PIK3CA;PIK3R1;PRKCG;ATP1A1;MED1;NOTCH4 |
| Oxytocin signaling pathway | PPP3CB;MAP2K1;TRPM2;RGS2;CACNB2;HRAS;GNAO1;PPP1R12C;GUCY1B3 |
| Alcoholism | HDAC1;HIST1H3E;SLC29A1;HIST1H2AI;DRD1A;HIST1H2BK;HIST1H2BE;CALM3;MAP2K1 |
| Hepatitis C | TRAF2;OAS1A;NFKBIA;CLDN20;CXCL8;TRADD;EIF2AK4;IFNA2;BAD |
| Hepatitis B | CASP8;SMAD3;PCNA;VDAC3;IFNA17;STAT6;IKBKG;EGR3;GRB2 |
| HTLV-I infection | TP53;CD3D;IL2RB;SLC2A1;POLB;HLA-DRB3;GPS2;FZD2;PDGFRA |
| Pathways in cancer | CKS2;RXRB;FGF12;MSH6;DAPK1;CASP9;GNG11;EGLN1;FGFR1 |
| Viral carcinogenesis | VAC14;SCRIB;ATP6V0D2;TRADD;CDC42;KRAS;ACTN2;DLG1;NFKB2 |
| Proteoglycans in cancer | WNT8B;AKT1;MAP2K1;PPP1CC;PTPN6;PRKACB;PIK3CA;ITGA5;CBLC |
| MicroRNAs in cancer | PIM1;EFNA3;HMGA2;ERBB3;FSCN1;TRIM71;CDC25C;MET;NOTCH4 |
| Renal cell carcinoma | PIK3CD;EGLN2;VHL;TGFB1;PIK3CA;PIK3CG;SOS1;MAP2K1;RAPGEF1 |
| Endometrial cancer | TCF7L2;APC;GSK3B;HRAS;FOXO3;AXIN2;TP53;CTNNA3;MLH1 |
| Glioma | RAF1;MAPK1;SOS1;IGF1R;PIK3R1;TRP53;IGF1;KRAS;CALM3 |
| Prostate cancer | CREB3L3;PDGFRA;IKBKG;TGFA;FGFR2;PIK3R2;RB1;PIK3CA;INS1 |
| Thyroid cancer | TP53;NTRK1;RXRG;RXRB;NRAS;CCDC6;PAX8;TFG;PPARG |
| Melanoma | FGF21;FGF20;FGF3;IGF1R;HGF;FGF22;TRP53;FGF7;PIK3R3 |
| Bladder cancer | THBS1;DAPK1;MAP2K2;MMP9;MAP2K1;TRP53;RB1;RAF1;ARAF |
| Chronic myeloid leukemia | TGFBR2;MDM2;PIK3CB;PTPN11;STAT5B;ARAF;CBL;RAF1;CRKL |
| Acute myeloid leukemia | RUNX1T1;PIK3CA;MYC;CHUK;ARAF;CEBPA;PIK3R5;MAPK1;PPARD |
| Non-small cell lung cancer | RXRG;RARB;PIK3R3;KRAS;BAD;PRKCB;MAP2K2;AKT1;ARAF |
| Central carbon metabolism in cancer | GLS2;C12orf5;PKM2;NTRK3;SLC2A2;SLC7A5;PIK3R1;TRP53;ERBB2 |
| Choline metabolism in cancer | PRKCB;DGKG;EIF4EBP1;PDGFC;CHKA;AKT2;PPAP2A;RHEB;SLC44A2 |
NRAS has several biochemical functions, for example, GTP binding, protein complex binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NRAS itself. We selected most functions NRAS had, and list some proteins which have the same functions with NRAS. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| GTP binding | AGAP1;RERGL;TUBAL3;RAB39B;DNM2;NUDT16;RHOBTB1;SRP54A;RAB7B |
| protein complex binding | KHDRBS1;CEBPA;NCK2;CYFIP1;CDK5RAP2;MYC;GRIN2A;WRN;CASP8 |
NRAS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NRAS here. Most of them are supplied by our site. Hope this information will be useful for your research of NRAS.
gtp; q46342_closo; Pik3ca; FBP2; RGL2; FRAT2; ALDOB; RASA1; XPA; DNAJB1; SRI; AKT1; STX17; RPS20; PPP2CB; EEF1A1; FANCC; CYLC2; SMAD1; MAPKAPK3
Huntzicker, EG; Hotzel, K; et al. Differential Effects of Targeting Notch Receptors in a Mouse Model of Liver Cancer. HEPATOLOGY 61:942-952(2015).
Ciombor, KK; Wu, C; et al. Recent Therapeutic Advances in the Treatment of Colorectal Cancer. ANNUAL REVIEW OF MEDICINE, VOL 66 66:83-95(2015).
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