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SOS1

Official Full Name

son of sevenless homolog 1 (Drosophila)
Overview

This gene encodes a protein that is a guanine nucleotide exchange factor for RAS proteins, membrane proteins that bind guanine nucleotides and participate in signal transduction pathways. GTP binding activates and GTP hydrolysis inactivates RAS proteins. The product of this gene may regulate RAS proteins by facilitating the exchange of GTP for GDP. Mutations in this gene are associated with gingival fibromatosis 1 and Noonan syndrome type 4. [provided by RefSeq, Jul 2008]
Synonyms

SOS1; son of sevenless homolog 1 (Drosophila); GF1; HGF; NS4; GGF1; GINGF; son of sevenless homolog 1; SOS-1; guanine nucleotide exchange factor; gingival fibromatosis, hereditary, 1;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	SOS1-1568HCL	Recombinant Human SOS1 293 Cell Lysate	HEK293	N/A		Inquiry
Human	SOS1-13H	Recombinant Human SOS1 Protein, His-tagged	E.coli	His		Inquiry
Human	SOS1-38H	Active Recombinant Human SOS1 Protein (564-1049), N-His tagged	E.coli	N-His	564-1049	Inquiry
Zebrafish	SOS1-5322Z	Recombinant Zebrafish SOS1	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
SOS1 Related Signal Pathway

SOS1 involved in several pathways and played different roles in them. We selected most pathways SOS1 participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SOS1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
MAPK signaling pathway	MEF2CA;BDNF;PPP3CC;GADD45B;DUSP16;CACNG6A;PAK1;GRB2;HRASA
ErbB signaling pathway	BAD;PTK2AB;PAK3;HBEGFA;MAPK8A;PTK2AA;PRKCB;GAB1;CAMK2D
Ras signaling pathway	ABL1;LAT;ARF6;FGF17;CALML3;CALM4;PDGFB;IGF1;PLD1
Chemokine signaling pathway	CCL19;CXCL16;PLCB2;RELA;HRAS;CXCL9;CCL23;CCR1L1;PIK3R5
FoxO signaling pathway	INS1;MAPK8B;FOXO1B;IGF1;FOXO1;INS;PIK3R3;IGF1R;SLC2A4
Phospholipase D signaling pathway	TSC1;AGPAT3;PLA2G4C;RALGDS;INSR;FYN;AGTR1B;CYTH1;DGKE
PIK-Akt signaling pathway	PIK3R1;NGFR;BAD;TLR4;PRKAA1;FGF21;PRLR;PPP2R5C;GNG11
Dorso-ventral axis formation	CPEB1A;SPIRE1;EGFRA;NOTCH1B;GRB2;PIWIL2;CPEB2;NOTCH1A;CPEB1
Focal adhesion	EGFRA;CAPN2B;FYNA;COL1A1;PARVB;COL27A1;ITGB5;CAPN2;TNK2
Gap junction	PRKCB;CDK1;GNAI1;TUBA1C;NRAS;SOS1;CSNK1DA;PDGFA;CX35B
Jak-STAT signaling pathway	IFNA13;GRB2B;IL9;IL13RA2;RAF1;SOS1;EPO;CTF1;TSLP
Natural killer cell mediated cytotoxicity	VAV3;ZAP70;PRKCG;KIR2DL4;TNFRSF10C;PPP3CC;KLRC1;KIR2DS3;IFNA12
T cell receptor signaling pathway	PDPK1;IKBKB;IL5;PAK3;PIK3R5;PPP3R1;CD8B;GRAPA;MAPK1
B cell receptor signaling pathway	MAPK4;CARD11;CD72;CDK2;PIK3R2;VAV1;CRKL;VAV2;LAT2
Fc epsilon RI signaling pathway	PIK3CG;IL3;LCP2;PIK3CD;IL13;PIK3R5;AKT2;IL4;VAV3
Neurotrophin signaling pathway	GSK3B;MAPK9;PIK3R5;PSEN1;NGFRAP1;MAP3K1;SH2B1;MAP2K2;CALML5
Regulation of actin cytoskeleton	INS2;RAC2;ITGB1;PIP4K2B;ABI2B;ACTN2;FGF3;PAK6B;FGF20
Insulin signaling pathway	IKBKB;SOCS1A;HK1;PRKACG;PIK3CA;PPP1CAB;ACACA;FBP1A;PRKACBB
GnRH signaling pathway	PTK2B;SOS1;RAF1;MAPK13;MAP2K4;LHB;PRKACBB;MAP2K3;CALM2
Estrogen signaling pathway	CALML3;GABBR2;ITPR3;MAP2K2;PRKACB;HSPA6;AKT1;HRAS;CREB5
Prolactin signaling pathway	ESR1;PIK3R2;SOCS2;MAPK9;FOS;CCND2;CCND1;PIK3R3;LHB
Alcoholism	GRIN3B;GNGT2;SHC2;HIST3H2A;HDAC7;GNB2;GNAO1;SLC29A1;HIST1H2AL
Hepatitis C	TRP53;CLDN16;MAPK10;Ifna15;ARAF;TP53;IFNB1;CLDN7;TNF
Pathways in cancer	BCL2L1;LPAR2;FOXO1;STK36;FZD9;DAPK3;PTCH1;LAMA2;AXIN2
Proteoglycans in cancer	LUM;PLCE1;IL12B;PTCH1;DROSHA;ITPR3;STAT3;GAB1;MAPK13
MicroRNAs in cancer	RECK;ROCK1;BAK1;ATM;PLCG2;UBE2I;RDX;SOX4;CYP24A1
Renal cell carcinoma	SLC2A1;BRAF;AHA-1;TCEB2;EP300;MAPK1;TGFB1;PDGFB;FLCN
Endometrial cancer	PIK3CB;PIK3CA;TCF7;PIK3R3;AXIN2;ELK1;TRP53;TP53;PIK3R5
Glioma	CAMK2B;PDGFRA;CAMK2A;PIK3R1;PIK3R3;SHC4;TP53;MAP2K1;CALM2
Prostate cancer	PDPK1;PDGFA;TP53;TGFA;BAD;IGF1R;MAP2K2;MAPK1;NFKB1
Chronic myeloid leukemia	MECOM;PIK3CA;CRK;TP53;STAT5B;RUNX1;HDAC1;MAPK1;PIK3R3
Acute myeloid leukemia	RAF1;PIK3R1;RARA;CCND1;AKT2;TCF7L2;MAP2K2;SPI1;PIK3CD
Non-small cell lung cancer	PLCG2;PIK3CB;PRKCG;PIK3R1;PIK3R5;GRB2;MAP2K2;EML4;FHIT
Choline metabolism in cancer	RPS6KB1;PIP5K1A;DGKE;LYPLA1;PDGFB;PIK3R5;DGKZ;PLA2G4F;SLC44A1

SOS1 has several biochemical functions, for example, DNA binding, GTPase activator activity, Ras guanyl-nucleotide exchange factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SOS1 itself. We selected most functions SOS1 had, and list some proteins which have the same functions with SOS1. You can find most of the proteins on our site.

Function	Related Protein
DNA binding	HOXD3;ZNF599;ZNF225;FOXP1B;DLX5A;ZIM2;SMYD1;HOXC3A;TFDP3
GTPase activator activity	RIC8B;ARFGAP1;ARHGAP31;ARAP1;TBC1D22B;TBC1D2;TBC1D8B;RALBP1;ARHGAP22
Ras guanyl-nucleotide exchange factor activity	RASGRP4;RASGRP1;RAB3A;RGL2;KNDC1;RASGRP3;RAPGEF5;ADRB1;RASGEF1BA
Rho guanyl-nucleotide exchange factor activity	FGD3;ARHGEF2;DOCK11;ITSN2A;FGD2;ARHGEF3;FGD;ARHGEF19;KALRNB
SH3 domain binding	INPPL1B;PDCD6IP;ADAM19;SH3BP1;ELMO3;ADAM10;ARHGAP27;SH3BP2;SHANK3
protein binding	SFRP4;SLC48A1;GNA13;STAU1;GPSM2;LY96;LNX2B;F3;AHCY
protein heterodimerization activity	HIST1H2BM;BNIP3L;SDCBP2;EXT1;TYRO3;ADD1;BRAF;MYOD1;SOX9

SOS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SOS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SOS1.

GRB2