ALDH7A1
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Official Full Name
aldehyde dehydrogenase 7 family, member A1
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Overview
The protein encoded by this gene is a member of subfamily 7 in the aldehyde dehydrogenase gene family. These enzymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. This particular member has homology to a previously described protein from the green garden pea, the 26g pea turgor protein. It is also involved in lysine catabolism that is known to occur in the mitochondrial matrix. Recent reports show that this protein is found both in the cytosol and the mitochondria, and the two forms likely arise from the use of alternative translation initiation sites. An additional variant encoding a different isoform has also been found for this gene. Mutations in this gene are associated with pyridoxine-dependent epilepsy. Several related pseudogenes have also been identified. -
Synonyms
ALDH7A1; aldehyde dehydrogenase 7 family, member A1; ATQ1; alpha-aminoadipic semialdehyde dehydrogenase; 26g turgor protein homolog; alpha AASA dehydrogenase; alpha aminoadipic semialdehyde dehydrogenase; antiquitin 1; delta1 piperideine 6 carboxylate dehydrogenease; EPD; P6c dehydrogenase; PDE; Aldehyde dehydrogenase 7 A1; Antiquitin; antiquitin-1; OTTHUMP00000159189; OTTHUMP00000242046; alpha-AASA dehydrogenase; betaine aldehyde dehydrogenase; delta1-piperideine-6-carboxylate dehydrogenase;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- MYC
- DDK
- N/A
- N
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | ALDH7A1-452H | Recombinant Human ALDH7A1 Protein, GST-tagged | Wheat Germ | GST | ||
Human | ALDH7A1-868H | Recombinant Human ALDH7A1 protein, His-tagged | E.coli | His | Ser2-Gln511 | |
Human | ALDH7A1-8915HCL | Recombinant Human ALDH7A1 293 Cell Lysate | HEK293 | N/A | ||
Human | ALDH7A1-1416HF | Recombinant Full Length Human ALDH7A1 Protein, GST-tagged | In Vitro Cell Free System | GST | 511 amino acids | |
Human | ALDH7A1-0391H | Recombinant Human ALDH7A1 Protein (Met1-Gln539), N-His-tagged | E.coli | N-His | Met1-Gln539 | |
Mouse | ALDH7A1-1533M | Recombinant Mouse ALDH7A1 Protein | Mammalian Cell | His | ||
Mouse | Aldh7a1-1358M | Recombinant Mouse Aldh7a1 protein, His-tagged | E.coli | His | Met29~Gln539 (Accession # Q9DBF1) | |
Mouse | ALDH7A1-459M | Recombinant Mouse ALDH7A1 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Mouse | Aldh7a1-481M | Recombinant Mouse Aldh7a1 Protein, MYC/DDK-tagged | HEK293T | MYC/DDK | ||
Mouse | ALDH7A1-459M-B | Recombinant Mouse ALDH7A1 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Rat | ALDH7A1-623R | Recombinant Rat ALDH7A1 Protein | Mammalian Cell | His | ||
Rat | Aldh7a1-1359R | Recombinant Rat Aldh7a1 protein, His-tagged | E.coli | His | Leu28~Gln539 (Accession # Q64057) | |
Rat | ALDH7A1-279R-B | Recombinant Rat ALDH7A1 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Rat | ALDH7A1-279R | Recombinant Rat ALDH7A1 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Zebrafish | ALDH7A1-11996Z | Recombinant Zebrafish ALDH7A1 | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
ALDH7A1 involved in several pathways and played different roles in them. We selected most pathways ALDH7A1 participated on our site, such as Glycolysis / Gluconeogenesis, Ascorbate and aldarate metabolism, Fatty acid degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with ALDH7A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Glycolysis / Gluconeogenesis | GPI1;ADH1B;GPIB;GAPDHS;TPI1A;ALDOAB;ALDOAA;ALDH3A1;DLAT |
Ascorbate and aldarate metabolism | UGT1AB;ALDH2;UGT1A4;UGT2B15;ALDH2.2;GKUP;UGT2A1;MIOX;UGT2B7 |
Fatty acid degradation | ADH6;ALDH3A2;HADHB;ALDH9A1B;ECI2;ACADM;ALDH2.1;ADH1A;ACSL4B |
Glycine, serine and threonine metabolism | SHMT1;GCSH;PSPH;PGAM1B;AGXT2;AGXTB;ALDH7A1;MAOA;CBSB |
Valine, leucine and isoleucine degradation | BCKDHA;BCAT2;AUH;OXCT2A;ALDH3A2A;DLDH;ALDH6A1;MCCC2;AOX3 |
Lysine biosynthesis | ALDH7A1;AADAT |
Lysine degradation | HADH;HYKK.2;GCDHA;ALDH9A1B;SETD1BA;PLOD1;DLST;SUV420H2;BBOX1 |
Arginine and proline metabolism | P4HA2;GOT2B;GOT2A;GAMT;AZIN2;MAOB;AMD1;CKB;SAT1A.1 |
Histidine metabolism | MAOA;ALDH1B1;HNMT;HAL;ASPA;ALDH3B2;ALDH7A1;FTCD;CARNS1 |
Tryptophan metabolism | GCDH;CYP1A;TDO2A;AOX2P;IL4I1;TPH1;TDO2B;AOX3;GCDHB |
beta-Alanine metabolism | GAD1;GAD1B;ACADM;HIBCH;CNDP1;ALDH3B1;ALDH3A1;ALDH2.2;MLYCD |
Glycerolipid metabolism | ALDH2.1;GLA;AGPAT9L;DGKQ;PPAP2B;MOGAT3;PNLIPRP3;PNPLA3;AKR1B1L |
Pyruvate metabolism | PKLR;ACAT1;ACACA;LDHC;ALDH1B1;ALDH2;ALDH9A1B;GRHPRB;ALDH2.1 |
Metabolic pathways | B4GALT3;CHKB;THTPA;INPP5J;NMNAT2;PKLR;GATC;PLCD3A;B3GALT2 |
Biosynthesis of amino acids | NAGS;GOT2;PSPH;IDH3G;MAT2A;PFKMA;ALDOA;TKTB;PKMA |
ALDH7A1 has several biochemical functions, for example, L-aminoadipate-semialdehyde dehydrogenase activity, aldehyde dehydrogenase (NAD) activity, betaine-aldehyde dehydrogenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ALDH7A1 itself. We selected most functions ALDH7A1 had, and list some proteins which have the same functions with ALDH7A1. You can find most of the proteins on our site.
Function | Related Protein |
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L-aminoadipate-semialdehyde dehydrogenase activity | |
aldehyde dehydrogenase (NAD) activity | ALDH9A1B;ALDH7A1;ALDH1A1;ALDH3A2A;ALDH9A1;ALDH3B2;ALDH3A2;ALDH1B1;ALDH3A2B |
betaine-aldehyde dehydrogenase activity | |
protein binding | SNRPF;ADI1;ABL1;WDR48;WDR25;TREX1;GADD45G;TNFRSF12A;ZC3H12A |
ALDH7A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ALDH7A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ALDH7A1.
EPS8; DDA1; UBA5; RECQL5; Rc3h2; Rc3h1
- Q&As
- Reviews
Q&As (14)
Ask a questionYes, ALDH7A1 deficiency can be diagnosed through genetic testing. Genetic testing can identify mutations in the ALDH7A1 gene, confirming the diagnosis of this condition. It is typically recommended to perform genetic testing for individuals with clinical signs and symptoms consistent with pyridoxine-dependent epilepsy.
Yes, researchers continue to investigate ALDH7A1 protein and its role in lysine metabolism, pyridoxine-dependent epilepsy, and other related disorders. Some studies focus on understanding the molecular mechanisms underlying ALDH7A1 deficiency and developing potential therapies for affected individuals.
ALDH7A1 protein is known to interact with certain proteins, such as DPC4/SMAD4 and SP1 transcription factor. These interactions may play a role in the regulation of gene expression and cellular processes.
ALDH7A1 protein has also been reported to be involved in the metabolism of pipecolic acid, which is derived from lysine and is important for the biosynthesis of neurotransmitters and the regulation of fatty acid metabolism.
There are no specific dietary recommendations solely for ALDH7A1 deficiency. However, as with any seizure disorder, it is generally recommended for individuals to follow a well-balanced diet and avoid triggers that may worsen seizures, such as excessive caffeine or alcohol consumption.
ALDH7A1 protein participates in the lysine degradation pathway.
Yes, the main treatment for pyridoxine-dependent epilepsy caused by ALDH7A1 deficiency is the administration of pyridoxine (vitamin B6) supplements. This treatment helps to bypass the metabolic pathway that is disrupted due to the ALDH7A1 deficiency and can effectively control seizures in most individuals with this condition. In some cases, additional medications may be prescribed to further manage the seizures.
The ALDH7A1 gene, which encodes the ALDH7A1 protein, is located on chromosome 5q31.3. Mutations in this gene can lead to the deficiency of ALDH7A1 protein, causing pyridoxine-dependent epilepsy.
The regulation of ALDH7A1 protein is not fully understood. However, studies suggest that its expression can be influenced by several factors, including hormonal signals, nutrient availability, and genetic variations.
ALDH7A1 deficiency itself is not considered a progressive disorder. However, if left untreated, the seizures associated with this condition can lead to developmental delays and intellectual disabilities. With early diagnosis and appropriate treatment, the prognosis for individuals with ALDH7A1 deficiency can be improved.
Yes, the ALDH7A1 protein is found in various tissues, including the brain, liver, kidney, and other organs. However, its expression levels may vary among tissues.
Yes, there are support groups and resources available for individuals and families affected by ALDH7A1 deficiency. Organizations such as the Pyridoxine-Dependent Epilepsy Family Association provide support, information, and resources for affected individuals and their families. Medical professionals can also provide guidance and connect individuals with the relevant support networks.
In addition to pyridoxine-dependent epilepsy, mutations in the ALDH7A1 gene can also cause a rare inherited disorder known as hyperlysinemia type 2. This condition is characterized by high levels of lysine in the blood, urine, and tissues.
Deficiency of ALDH7A1 protein results in a rare metabolic disorder called pyridoxine-dependent epilepsy (PDE). This disorder is characterized by seizures that are unresponsive to conventional anti-seizure medications but can be controlled with the administration of vitamin B6 (pyridoxine) or its active form pyridoxal-5'-phosphate.
Customer Reviews (3)
Write a reviewI highly recommend the ALDH7A1 Protein to fellow researchers seeking a high-quality protein that not only meets their experimental requirements but is also accompanied by exceptional technical support.
The ALDH7A1 Protein's consistent stability and robust performance make it an indispensable tool for studying its multifaceted roles and mechanisms within vital biochemical pathways and cellular processes.
What truly distinguishes the ALDH7A1 Protein is the unparalleled technical support provided by the manufacturer.
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