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PPP2R1A

  • Official Full Name

    protein phosphatase 2, regulatory subunit A, alpha

  • Overview

    This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes an alpha isoform of the constant regulatory subunit A. Alternatively spliced transcript variants have been described.
  • Synonyms

    PPP2R1A; protein phosphatase 2, regulatory subunit A, alpha; protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform , protein phosphatase 2 (formerly 2A), regulatory subunit A, alpha isoform; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform; PP2A Aalpha; PR65A; protein phosphatase 2; 65kDa regulatory subunit A; protein phosphatase 2A; regulatory subunit A; alpha isoform; 6330556D22Rik; Alpha isoform of regulatory subunit A, protein phosphatase; DKFZp470L0914; Medium tumor antigen-associated 61 kDa protein; MGC128399; MGC786; MGC83000; MGC95083; PP2A; PP2A subunit A PR65-alpha isoform; PP2A subunit A R1 alpha isoform; PP2A, subunit A, PR65-alpha isoform; PP2A, subunit A, R1-alpha isoform; ppp2r1a-b; PR65; Protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform; Protein phosphatase 2 (Formerly 2A), regulatory subunit A (PR 65), alpha isoform, isoform CRA_a; Protein phosphatase 2 (formerly 2A), regulatory subunit A,; Protein phosphatase 2 regulatory subunit A alpha isoform; Protein phosphatase 2, 65-KD regulatory subunit A, alpha; Protein phosphatase 2, regulatory subunit A, alpha isoform; Protein phosphatase 2, structural/regulatory subunit A, alpha; Serine threonine protein phosphatase 65 kDa; Serine/threonine protein phosphatase 2A 65 KDA regulatory subunit A alpha isoform; PP2A subunit A isoform R1-alpha; PP2A subunit A isoform PR65-alpha; protein phosphatase 2 (formerly 2A), regulatory subunit A (P; PP2AAALPHA; PP2A-Aalpha;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Sf9 insect cells
  • C
  • His
  • Flag
  • GST
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PPP2R1A-37H Recombinant Human PPP2R1A protein, His-tagged Insect Cell His
Human PPP2R1A-43H Recombinant Human PPP2R1A protein, His-tagged E.coli His
Human PPP2R1A-27571TH Recombinant Human PPP2R1A, His-tagged E.coli His
Human PPP2R1A-1914H Recombinant Human PPP2R1A, GST-tagged E.coli GST 239-589aa
Human PPP2R1A-2926HCL Recombinant Human PPP2R1A 293 Cell Lysate HEK293 N/A
Human PPP2R1A-5688H Recombinant Human PPP2R1A Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human PPP2R1A-49H Recombinant Human PPP2R1A Protein, Full Length, N-GST tagged Sf9 insect cells N-GST Full Length
Human PPP2R1A-1750H Recombinant Human PPP2R1A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human PPP2R1A-281HFL Recombinant Full Length Human PPP2R1A Protein, C-Flag-tagged Mammalian cells Flag
Human PPP2R1A-1750H-B Recombinant Human PPP2R1A Protein Pre-coupled Magnetic Beads HEK293
Human PPP2R1A-5964H Recombinant Human PPP2R1A Protein (Met180-Ala589), C-His tagged E.coli C-His Met180-Ala589
Mouse PPP2R1A-13251M Recombinant Mouse PPP2R1A Protein Mammalian Cell His
Mouse PPP2R1A-7031M-B Recombinant Mouse PPP2R1A Protein Pre-coupled Magnetic Beads HEK293
Mouse PPP2R1A-7031M Recombinant Mouse PPP2R1A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Ppp2r1a-5078M Recombinant Mouse Ppp2r1a Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Ppp2r1a-6778M Recombinant Mouse Ppp2r1a Protein (Met1-Ala589), C-His tagged E.coli C-His Met1-Ala589
Rhesus Macaque PPP2R1A-3571R Recombinant Rhesus monkey PPP2R1A Protein, His-tagged Mammalian Cell His
Rhesus Macaque PPP2R1A-3389R Recombinant Rhesus Macaque PPP2R1A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque PPP2R1A-3389R-B Recombinant Rhesus Macaque PPP2R1A Protein Pre-coupled Magnetic Beads HEK293
Zebrafish PPP2R1A-12554Z Recombinant Zebrafish PPP2R1A Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PPP2R1A Related Articles
  • PPP2R1A Related Research Area

PPP2R1A involved in several pathways and played different roles in them. We selected most pathways PPP2R1A participated on our site, such as mRNA surveillance pathway, Sphingolipid signaling pathway, Oocyte meiosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with PPP2R1A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
mRNA surveillance pathwayCASC3;UPF3B;PPP1CAA;PPP2R5A;MSI1;ETF1A;EIF4A3;PPP1CB;CPSF2
Sphingolipid signaling pathwayPRKCG;MAPK13;RHOA;AKT2;KRAS;MAPK11;PPP2R5B;TRAF2;MAPK1
Oocyte meiosisCAMK2D;PPP2R5A;CTH1;FBXO43;INS1;YWHAQA;PPP2R5EA;CALM2B;STAG3
PIK-Akt signaling pathwayPIK3CB;RAC1;FGF19;HSP90AA1;IL3RA;PDGFB;FOXO3;Il6ra;IGF1R
AMPK signaling pathwayPFKFB3;GYS1;PPP2R2D;PPP2R1B;IGF1R;SIRT1;RAB11B;G6PC2;RAB2A
Adrenergic signaling in cardiomyocytesPPP2R5CB;TPM4B;GNA11A;GNA15.4;RAPGEF4;PIK3CB;TNNC1A;CAMK2A;RAPGEF3
TGF-beta signaling pathwayNOG2;TNF;IFNG1-2;BMPR2B;PITX2;CUL1;SKP1;NBL1;THBS1
Hippo signaling pathwayWNT5A;STK3;WNT7A;BMP6;APC2;WNT5B;ITGB2;PARD6A;SAV1
Tight junctionRHOAA;PRKCA;MYH8;VMHC;SHROOM3;SYMPK;PRKCG;RRAS2;CASKA
Dopaminergic synapseCREB3L4;DRD5;CREB5;GNAS;DRD1;CALM4;GNGT2;PPP3CA;PPP2R2C
Long-term depressionPPP2CB;GRIA3;ARAF;MAP2K2;MAPK1;GNAS;GRIA2;NOS1;NRAS
Chagas disease (American trypanosomiasis)TLR9;NFKB1;IL12A;IFNB1;GNA11;SMAD2;PPP2R1B;GNAL;PIK3R2
Hepatitis COAS1B;IRF3;IFNA5;CLDN8;OAS1;NRAS;CLDN7;STAT2;CXCL8

PPP2R1A has several biochemical functions, for example, antigen binding, protein binding, protein heterodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PPP2R1A itself. We selected most functions PPP2R1A had, and list some proteins which have the same functions with PPP2R1A. You can find most of the proteins on our site.

Function Related Protein
antigen bindingIGKC;KIR2DL3;IGHM;TSPAN4;LILRB4;IGLL1;IGJ;FCN3;MHC1UKA
protein bindingRSL24D1;IQUB;TTC1;RCAN3;JAKMIP1;ZNF496;PMP2;TNNI2;HFE
protein heterodimerization activityKCNH5;CENPA;TIMELESS;HIST1H2A9;TAF6L;GABRR1;SDCBP;HIST2H3C;TWIST1
protein phosphatase type 2A regulator activityPPP2R2D;PPP2R5CB;PPP2R5D;PPME1;EIF2AK2;PPP2R1A;IGBP1;SET;PPP2R2CA
protein serine/threonine phosphatase activityPPEF1;PPP1R3C;PPM1NB;PPP6C;PPM1DA;PDP2;PPP2R5D;MTMR6;ILKAP

PPP2R1A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPP2R1A here. Most of them are supplied by our site. Hope this information will be useful for your research of PPP2R1A.

PPP2CA; PPP2R2A

Becsi, B; Dedinszki, D; et al. Identification of protein phosphatase interacting proteins from normal and UVA-irradiated HaCaT cell lysates by surface plasmon resonance based binding technique using biotin-microcystin-LR as phosphatase capturing molecule. JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY 138:240-248(2014).
Yao, MY; Rogers, NM; et al. Thrombospondin-1 Activation of Signal-Regulatory Protein-alpha Stimulates Reactive Oxygen Species Production and Promotes Renal Ischemia Reperfusion Injury. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY 25:1171-1186(2014).
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