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RAB3GAP2

Official Full Name

RAB3 GTPase activating protein subunit 2 (non-catalytic)
Overview

The protein encoded by this gene belongs to the RAB3 protein family, members of which are involved in regulated exocytosis of neurotransmitters and hormones. This protein forms the Rab3 GTPase-activating complex with RAB3GAP1, where it constitutes the regulatory subunit, whereas the latter functions as the catalytic subunit. This gene has the highest level of expression in the brain, consistent with it having a key role in neurodevelopment. Mutations in this gene are associated with Martsolf syndrome.
Synonyms

RAB3GAP2; RAB3 GTPase activating protein subunit 2 (non-catalytic); rab3 GTPase-activating protein non-catalytic subunit; DKFZP434D245; KIAA0839; RAB3 GAP150; RGAP-iso; rab3-GAP p150; rab3-GAP regulatory subunit; rab3 GTPase-activating protein 150 kDa sub;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Rat
Zebrafish

Source

E.coli
HEK293
Mammalian Cell

Tag

His
His (Fc)
Avi

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	RAB3GAP2-2123H	Recombinant Human RAB3GAP2, His-tagged	E.coli	His	1-204aa	$319 / 25ug
Rat	RAB3GAP2-4893R	Recombinant Rat RAB3GAP2 Protein	Mammalian Cell	His		Inquiry
Rat	RAB3GAP2-4552R	Recombinant Rat RAB3GAP2 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	RAB3GAP2-4552R-B	Recombinant Rat RAB3GAP2 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	RAB3GAP2-1254Z	Recombinant Zebrafish RAB3GAP2	Mammalian Cell	His		Inquiry
Chicken	RAB3GAP2-3995C	Recombinant Chicken RAB3GAP2	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
RAB3GAP2 Related Articles

RAB3GAP2 involved in several pathways and played different roles in them. We selected most pathways RAB3GAP2 participated on our site, such as Effects of Botulinum toxin, which may be useful for your reference. Also, other proteins which involved in the same pathway with RAB3GAP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Effects of Botulinum toxin	CHRNA1;UNC13B;RAB3GAP2;CCDC167

RAB3GAP2 has several biochemical functions, for example, GTPase activator activity, Rab GTPase binding, contributes_to Rab guanyl-nucleotide exchange factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RAB3GAP2 itself. We selected most functions RAB3GAP2 had, and list some proteins which have the same functions with RAB3GAP2. You can find most of the proteins on our site.

Function	Related Protein
GTPase activator activity	ASAP2B;EVI5L;ALDH1A2;SRGAP2;RGS3;FAM13B1;TBC1D22B;TBC1D3;RGS5A
Rab GTPase binding	ACAP2;RGP1;RUSC2;RABGGTB;LLGL2;MLPH;UNC13D;RIMS1;NGFR
contributes_to Rab guanyl-nucleotide exchange factor activity	RAB3GAP2;RAB3GAP1
enzyme activator activity	CXCL1;DBNL;RAB3GAP2;CFLAR;PSAPL1;DCP1A;MMP16;UBA2;TAB1
enzyme regulator activity	DPM2;PPP1R7;PSMD3;DCP1B;BRCC3;PSMD2;GCLM;EIF2B1;ATP6V1H
protein heterodimerization activity	TBX15;HIST1H4E;HIST1H2BF;PDGFA;VEGFB;SOX5;TTR;IKZF3;HIST1H2BK

RAB3GAP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RAB3GAP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of RAB3GAP2.

MAP1LC3A; PTP4A3; ARF6; GSTK1; pi3p; GABARAP

Park, AK; Liegel, RP; et al. Targeted disruption of Tbc1d20 with zinc-finger nucleases causes cataracts and testicular abnormalities in mice. BMC GENETICS 15:-(2014).

Spang, N; Feldmann, A; et al. RAB3GAP1 and RAB3GAP2 modulate basal and rapamycin-induced autophagy. AUTOPHAGY 10:2297-2309(2014).