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RAG1

Official Full Name

recombination activating gene 1
Overview

The sequences encoding antigen receptors are split into multiple germline segments which are then combined by a process called V(D)J recombination during immune cells development. A variable (V) segment is combined with a joining (J) segment, and in some
Synonyms

RAG1; recombination activating gene 1; V(D)J recombination-activating protein 1; MGC43321; recombination activating protein 1; RING finger protein 74; RNF74; V(D)J recombination activating protein 1; RAG-1;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Chicken
Mouse
Rhesus Macaque
Zebrafish

Source

HEK293
Mammalian Cell

Tag

His
His (Fc)
Avi

Species	Cat.#	Product name	Source (Host)	Tag	Price
Mouse	RAG1-13889M	Recombinant Mouse RAG1 Protein	Mammalian Cell	His	Inquiry
Mouse	RAG1-7400M-B	Recombinant Mouse RAG1 Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Mouse	RAG1-7400M	Recombinant Mouse RAG1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry
Rhesus Macaque	RAG1-3776R	Recombinant Rhesus monkey RAG1 Protein, His-tagged	Mammalian Cell	His	Inquiry
Rhesus Macaque	RAG1-3593R-B	Recombinant Rhesus Macaque RAG1 Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Rhesus Macaque	RAG1-3593R	Recombinant Rhesus Macaque RAG1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry
Zebrafish	RAG1-8963Z	Recombinant Zebrafish RAG1	Mammalian Cell	His	Inquiry
Chicken	RAG1-2853C	Recombinant Chicken RAG1	Mammalian Cell	His	Inquiry

Involved Pathway
Protein Function
Interacting Protein
RAG1 Related Articles

RAG1 involved in several pathways and played different roles in them. We selected most pathways RAG1 participated on our site, such as FoxO signaling pathway, Primary i, nodeficiency, which may be useful for your reference. Also, other proteins which involved in the same pathway with RAG1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
FoxO signaling pathway	PLK1;IGF1RB;KRAS;BNIP4;RBL2;IRS2;GABARAPL2;RAF1A;IGF1R
Primary i	CD8B;RAG2;AIRE;CD4;CD40;CD8A;ZAP70;CD3E;IL7R
nodeficiency	IL7R;PTPRC;CD8B;ZAP70;AICDA;RAG2;BLNK;RAG1;RFXAP

RAG1 has several biochemical functions, for example, DNA binding, T/G mismatch-specific endonuclease activity, UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RAG1 itself. We selected most functions RAG1 had, and list some proteins which have the same functions with RAG1. You can find most of the proteins on our site.

Function	Related Protein
DNA binding	SPATA24;HIST1H2BJ;POLR1C;ZFPM1;CBFB;PHTF2;EF1;ASCL3;DNASE1L2
T/G mismatch-specific endonuclease activity	MEIOB;ZRANB3;SMG6;EXO5;RNASEKB;RNASEKA;GDPD4;REXO4;REXO1
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity	DTX1;SIAH2L;LTN1;MARCH6;RFWD2;RAG1;MARCH11;NEURL3;UBE2IB
acid-amino acid ligase activity	RNF41;RAG1;TRIM25;UBA3
catalytic activity	PBLD1;GOT2B;PCYT1AB;NRD1B;NANSB;ISOC2;MOGS;ETNPPL;PCYT1AA
coenzyme F420-0 gamma-glutamyl ligase activity	TRIM71;RC3H2;UBR1;MARCH5L;RNF180;HECW2;MARCH11;MARCH6;RNF144AB
coenzyme F420-2 alpha-glutamyl ligase activity	LTN1;RC3H2;MUL1A;SIAH1A;MARCH6;RFWD2;RNF149;UBE2IB;SIAH2L
endonuclease activity	EAR1;OGG1;EAR14;G3BP1;ERN2;SETMAR;PNKP;ANG;ENDOU2
histone binding	SERPINB1A;NCAPD2;JAK2;HIST1H4M;SART3;ANP32E;SET;HIST1H3G;HIST2H4
hydrolase activity	HAGHL;CTDNEP1;SHHA;ADAMTS7;ATP2B1;CTDNEP1A;MEIOB;RTEL1;HE2
hydrolase activity, acting on ester bonds	ASPA;LIPM;SMFN;ACY3.1;LIPK;APMAP;LIPN;RAG1;C11orf54
ligase activity	RNF115;RNF149;HUWE1;RNF144A;MIB1;BIRC2;UBE3B;STUB1;DTX4
metal ion binding	MAT2AB;SPNA1;PRDM1A;ZFP879;FGD1;ZIC2A;DOHH;ZFP36L1;XPNPEP2
nuclease activity	EXOSC9;TMPPE;DNASE2A;EXO5;EAR5;USB1;PARN;FANCM;REXO1
nucleic acid binding	DHX36;ZFP92;SP3A;SNRNP27;YY1B;EAR3;PRDM12B;EWSR1B;ZNF219
phosphoric ester hydrolase activity	SACM1L;TMPPE;SYNJ1;SACM1LB;RNASEKA;SMG6;INPP5F;RAG1;MEIOB
protein binding	Shh;COMMD2;HNRNPUL1;NPC2;TMEM119;MCM4;RLN3;STXBP2;LRP2
protein homodimerization activity	BHLHE40;ERBB4;FBXO4;ASNS;GDNF;LDB1;PVRL3;SETMAR;MYPOP
protein-glutamic acid ligase activity	RNF144AB;MUL1A;TRIM50;UBE2IB;MGRN1A;ZNRF2B;SHRPRBCK1R;SIAH1A;RNF144AA
protein-glycine ligase activity	MARCH9;TRIM41;TRIM71;TMEM129;RNF149;MARCH11;LTN1;NEURL3;UBE2IB
protein-glycine ligase activity, elongating	TRIM71;RC3H2;TRIM50;NEURL3;SIAH1A;MGRN1A;MARCH11;RNF149;RFWD2
protein-glycine ligase activity, initiating	HERC2;SIAH1A;NEURL1B;SHRPRBCK1R;MARCH6;G2E3;ZNRF3;RNF144AB;TRIM41
retroviral 3 processing activity	ZRANB3;ENDOU2;RAG1;REXO4;RNASEKB;GDPD4;EXO5;REXO1;SMG6
ribosomal S6-glutamic acid ligase activity	UBE2IA;RAG1;SIAH2L;TRIM41;TRIM50;NEURL1B;RFWD2;TMEM129;SHRPRBCK1R
sequence-specific DNA binding	TBX5;DLX4A;TCF7L1A;ZNF187;DBPB;TLX2;HOXC11A;POU2F1A;LHX1A
tubulin-glutamic acid ligase activity	RFWD2;RNF144AB;MARCH9;HERC2;MUL1A;MARCH6;ARIH1L;TMEM129;NEURL3
tubulin-glycine ligase activity	ZNRF3;FLR;TRIM50;NEURL1B;MYLIPA;MUL1A;MARCH4;RNF180;TRIM71
ubiquitin protein ligase activity	RNF146;UBE3C;TRAIP;BRAP;ANKIB1;ITCH;UBE2H;CBL;LTN1
ubiquitin-protein transferase activity	MDM2;RNF4;RNF181;FBXL6;PAX6;MIB1;BIRC5;BIRC2;PRKCQ
zinc ion binding	ZDHHC3A;MARCH1;ZACN;SMAD3;ADAM12;PPARG;ESR1;LNX2A;UBR2

RAG1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RAG1 here. Most of them are supplied by our site. Hope this information will be useful for your research of RAG1.

Rag2; VPRBP; KPNA1; Ywhae; CUL4A

Aird, AL; Nevitt, CD; et al. Adipose-derived stromal vascular fraction cells isolated from old animals exhibit reduced capacity to support the formation of microvascular networks. EXPERIMENTAL GERONTOLOGY 63:18-26(2015).

Zhang, Y; Hu, XY; et al. Anti-CD40-induced inflammatory E-cadherin plus dendritic cells enhance T cell responses and antitumour immunity in murine Lewis lung carcinoma. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH 34:-(2015).