SLC26A5
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Official Full Name
solute carrier family 26, member 5 (prestin)
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Overview
This gene encodes a member of the SLC26A/SulP transporter family. The protein functions as a molecular motor in motile outer hair cells (OHCs) of the cochlea, inducing changes in cell length that act to amplify sound levels. The transmembrane protein is an incomplete anion transporter, and does not allow anions to cross the cell membrane but instead undergoes a conformational change in response to changes in intracellular Cl- levels that results in a change in cell length. The protein functions at microsecond rates, which is several orders of magnitude faster than conventional molecular motor proteins. Mutations in this gene are potential candidates for causing neurosensory deafness. Multiple transcript variants encoding different isoforms have been found for this gene. -
Synonyms
SLC26A5; solute carrier family 26, member 5 (prestin); PRES, prestin (motor protein); prestin; deafness; neurosensory; autosomal recessive; 61; DFNB61; Deafness neurosensory autosomal recessive 61; DFNB 61; MGC118886; MGC118887; MGC118888; MGC118889; PRES; Prestin (motor protein); S26A5_HUMAN; Solute carrier family 26 member 5 (prestin); Solute carrier family 26 member 5; OTTHUMP00000195085; OTTHUMP00000195086; OTTHUMP00000195087; OTTHUMP00000195088; OTTHUMP00000195089; OTTHUMP00000195090; OTTHUMP00000195091; OTTHUMP00000195092; OTTHUMP00000211775; OTTHUMP00000211776;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Pig
- Rat
- Zebrafish
- E.coli
- HEK293
- Mammalian Cell
- Wheat Germ
- Yeast
- GST
- His
- His (Fc)
- Avi
- N
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | SLC26A5-112H | Recombinant Human SLC26A5, GST-tagged | Wheat Germ | GST | ||
Human | SLC26A5-1520H | Recombinant Human SLC26A5 Protein, His-tagged | Yeast | His | ||
Mouse | SLC26A5-15343M | Recombinant Mouse SLC26A5 Protein | Mammalian Cell | His | ||
Mouse | SLC26A5-8302M-B | Recombinant Mouse SLC26A5 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Mouse | SLC26A5-8302M | Recombinant Mouse SLC26A5 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Rat | SLC26A5-5486R | Recombinant Rat SLC26A5 Protein | Mammalian Cell | His | ||
Rat | SLC26A5-5145R | Recombinant Rat SLC26A5 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Rat | SLC26A5-5145R-B | Recombinant Rat SLC26A5 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Zebrafish | SLC26A5-11519Z | Recombinant Zebrafish SLC26A5 | Mammalian Cell | His | ||
Pig | SLC26A5-1190P | Recombinant Pig SLC26A5 Protein, His-tagged | E.coli | N-His | Ala524-Ser712 | |
Chicken | SLC26A5-3517C | Recombinant Chicken SLC26A5 | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
- SLC26A5 Related Articles
SLC26A5 involved in several pathways and played different roles in them. We selected most pathways SLC26A5 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC26A5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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SLC26A5 has several biochemical functions, for example, anion:anion antiporter activity, bicarbonate transmembrane transporter activity, chloride channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC26A5 itself. We selected most functions SLC26A5 had, and list some proteins which have the same functions with SLC26A5. You can find most of the proteins on our site.
Function | Related Protein |
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anion:anion antiporter activity | SLC26A6;SLC4A8;SLC4A11;SLC26A3;SLC26A5;SLC4A1;SLC26A3.1;SLC22A9;SLC26A2 |
bicarbonate transmembrane transporter activity | SLC26A4;SLC4A1B;SLC4A1;SLC26A11;CFTR;SLC26A1;SLC4A11;SLC26A9;SLC26A2 |
chloride channel activity | SLC1A4;CLICA;SLC26A3;TTYH3B;ANO2;CLIC6;TTYH2;SLC26A3.1;SLC26A9 |
oxalate transmembrane transporter activity | SLC26A6;SLC26A3;SLC26A11;SLC26A3.1;SLC26A6L;SLC26A4;SLC26A5;SLC26A2;SLC26A9 |
protein homodimerization activity | PVR;RPS19;ATP2A1;LCN2;DPYD;GABRR1;ANXA9;TERF2;BAX |
secondary active sulfate transmembrane transporter activity | SLC26A3;SLC26A6L;SLC13A1;SLC26A7;SLC26A3.1;SLC26A3.2;SLC26A4;SLC26A5;SLC26A6 |
spectrin binding | SLC26A5;USH1G;MYO7A;EPB41;GNB1;KIF3A;PDE6G;UNC13A;SPTAN1 |
sulfate transmembrane transporter activity | SLC26A11;SLC26A3;SLC26A2;SLC26A9;SLC26A4;SLC26A7;SLC26A3.2;SLC26A1;SLC26A3.1 |
transcription factor binding | NFYC;KAT2B;POU5F1;HDAC3;PPP1R13B;CCND1;PRKDC;MLXIPL;APBB2 |
SLC26A5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC26A5 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC26A5.
- Q&As
- Reviews
Q&As (5)
Ask a questionSLC26A5 mutations are relatively rare compared to other genetic causes of hearing loss, but they are implicated in certain cases of hereditary hearing impairment.
As of now, there are no SLC26A5-specific treatments approved for widespread clinical use, but research continues in this field.
Progress in understanding SLC26A5 could pave the way for innovative treatments that specifically target the underlying causes of certain types of hearing loss.
The effectiveness of SLC26A5-targeted therapies in fully restoring hearing largely depends on the nature and extent of the mutation and its impact on outer hair cell function.
While primarily associated with genetic hearing loss, understanding SLC26A5 function could provide insights into age-related hearing decline and potential interventions.
Customer Reviews (3)
Write a reviewThis collaborative partnership greatly contributes to the success of my research projects and facilitates meaningful contributions to the scientific community.
The manufacturer's support and expertise further enhance the utility of SLC26A5 in my experimental work, ensuring reliable and high-quality results.
Another advantage of using SLC26A5 protein in trials is its potential as a therapeutic agent.
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