Creative BioMart to Present at IMMUNOLOGY2024™|May 3-7, 2024|Booth #512 Learn More

SLC4A4

Official Full Name

solute carrier family 4, sodium bicarbonate cotransporter, member 4
Overview

This gene encodes a sodium bicarbonate cotransporter (NBC) involved in the regulation of bicarbonate secretion and absorption and intracellular pH. Mutations in this gene are associated with proximal renal tubular acidosis. Multiple transcript variants encoding different isoforms have been found for this gene.
Synonyms

SLC4A4; solute carrier family 4, sodium bicarbonate cotransporter, member 4; electrogenic sodium bicarbonate cotransporter 1; NBC-like protein; Na+HCO3- cotransporter 4; Na(+)/HCO3(-) cotransporter; sodium bicarbonate cotransporter; solute carrier family;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Rat

Source

E.coli
HEK293
Mammalian Cell

Tag

GST
His
His (Fc)
Avi

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	SLC4A4-505H	Recombinant Human SLC4A4 , His-tagged	E.coli	His		Inquiry
Human	SLC4A4-31418TH	Recombinant Human SLC4A4, His-tagged	E.coli	His	424 amino acids	Inquiry
Human	SLC4A4-31419TH	Recombinant Human SLC4A4, His-tagged	E.coli	His		Inquiry
Human	SLC4A4-2775H	Recombinant Human SLC4A4, GST-tagged	E.coli	GST	25-354aa	$319 / 25ug
Rat	SLC4A4-5551R	Recombinant Rat SLC4A4 Protein	Mammalian Cell	His		Inquiry
Rat	SLC4A4-5210R-B	Recombinant Rat SLC4A4 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rat	SLC4A4-5210R	Recombinant Rat SLC4A4 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry

Involved Pathway
Protein Function
Interacting Protein
SLC4A4 Related Articles

SLC4A4 involved in several pathways and played different roles in them. We selected most pathways SLC4A4 participated on our site, such as Proximal tubule bicarbonate reclamation, Pancreatic secretion, Bile secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC4A4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Proximal tubule bicarbonate reclamation	ATP1B3;ATP1A1;SLC4A4;PCK1;AQP1;Car4;SLC25A10;SLC38A3;ATP1B4
Pancreatic secretion	ATP1A2;CPA2;RAP1B;PRSS1;RAB3D;CLCA5;ITPR3;ATP2A3;CLCA2
Bile secretion	SULT2A1;SCARB1;ADCY3;AQP8;SLCO1B1;ATP1A2;KCNN2;SLC22A1;AQP1

SLC4A4 has several biochemical functions, for example, inorganic anion exchanger activity, protein binding, sodium:bicarbonate symporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC4A4 itself. We selected most functions SLC4A4 had, and list some proteins which have the same functions with SLC4A4. You can find most of the proteins on our site.

Function	Related Protein
inorganic anion exchanger activity	SLC22A6;Slc4a2;SLC4A4;SLC22A20;SLC4A2B;SLC4A3;SLC22A8;SLC4A1A;SLC4A1
protein binding	SFN;C4orf19;RAB9B;VEGFA;CTPS2;UBL4A;MRPL44;PALM;DHX8
sodium:bicarbonate symporter activity	SLC26A3.1;SLC26A6L;SLC4A8;SLC4A4A;SLC4A4

SLC4A4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC4A4 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC4A4.

CA4; SREBF2; glpF

Jalali, R; Guo, J; et al. NBCe1 (SLC4A4) a potential pH regulator in enamel organ cells during enamel development in the mouse. CELL AND TISSUE RESEARCH 358:433-442(2014).

Gregorio, SF; Carvalho, ESM; et al. Endocrine regulation of carbonate precipitate formation in marine fish intestine by stanniocalcin and PTHrP. JOURNAL OF EXPERIMENTAL BIOLOGY 217:1555-1562(2014).