TAB2
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Official Full Name
TGF-beta activated kinase 1/MAP3K7 binding protein 2
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Overview
TAK1 is a mitogen-activated protein kinase kinase kinase activated by TGF-beta and various pro-inflammatory signals. In vivo, TAK1 activation requires its association with TAK1 binding protein 1 (TAB1), which triggers TAK1 autophosphorylation at Thr184 an -
Synonyms
TAB2; TGF-beta activated kinase 1/MAP3K7 binding protein 2; MAP3K7IP2, mitogen activated protein kinase kinase kinase 7 interacting protein 2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2; KIAA0733; TAB-2; TAK1-binding protein 2; TGF-beta-act;
- Cell & Tissue Lysates
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- Insect Cell
- Mammalian Cell
- GST
- His
- His (Fc)
- Avi
- His|Myc
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- TAB2 Related Articles
TAB2 involved in several pathways and played different roles in them. We selected most pathways TAB2 participated on our site, such as MAPK signaling pathway, NF-kappa B signaling pathway, Osteoclast differentiation, which may be useful for your reference. Also, other proteins which involved in the same pathway with TAB2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| MAPK signaling pathway | FGF19;PPP3R2;CACNB1;ARRB2A;TGFBR1B;MAP3K13;MAX;PRKACAB;FGF7 |
| NF-kappa B signaling pathway | CCL21;CCL19;BCL10;CXCL2;BCL2;LTBR;MAP3K14;TNF;ERC1 |
| Osteoclast differentiation | LILRB5;MITF;BTK;TRAF2;PIK3CB;PPARG;LILRA2;FYN;MAPK3 |
| Toll-like receptor signaling pathway | PIK3CG;CCL3L3;LBP;IKBKG;IFNA17;CCL3L1;TLR4BB;RIPK1;IRAK4 |
| NOD-like receptor signaling pathway | NAIP1;IL-8;SGUT1;IL1B;TNF;PSTPIP1;CARD8;MAPK12B;MAPK10 |
| TNF signaling pathway | CCL5;PIK3CD;TNFAIP3;MAPK10;MAPK9;PIK3R3;MAP3K7IP3;MAGI2;LTA |
| Leishmaniasis | TGFB3;IL12B;TRAF6;HLA-DPB1;NFKB1;ITGB2L;MAPK1;HLA-DOA;ITGB1 |
| Toxoplasmosis | HLA-DOB;TGFB3;BIRC7;Toxoplasma Gondii Profilin Family Protein;STAT1;Toxoplasma Gondii Microneme Protein MIC3;LAMC1;HSPA6;PIK3R2 |
| Measles | FAS;TNFRSF10A;IRAK1;TNFSF10;HSPA1L;PIK3CB;FYN;IKBKE;IL13 |
| Herpes simplex infection | IFNA1;SRSF9;BF1;NXF1;PPP1CC;PER1A;MAPK9;HLA-DPA1;ARNTL1A |
| Epstein-Barr virus infection | TRP53;HSPA2;AKAP8L;RELA;SPI1;GTF2B;IKBKB;GTF2E1;YWHAZ |
TAB2 has several biochemical functions, for example, K63-linked polyubiquitin binding, protein binding, zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TAB2 itself. We selected most functions TAB2 had, and list some proteins which have the same functions with TAB2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| K63-linked polyubiquitin binding | RNF169;IKBKG;UIMC1;ZRANB1;OTUD7B;SQSTM1;RNF168;TNFAIP3;ZRANB1B |
| protein binding | HIST1H2AI;KISS1R;KDM5A;SPSB2;GDI2;TCEB3;AMHR2;ANXA5;LCMT1 |
| zinc ion binding | MT3;TRIM35-1;PYGO2;SH3RF2;ZMIZ1;RABGGTB;GFI1;DBF4B;APEX2 |
TAB2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TAB2 here. Most of them are supplied by our site. Hope this information will be useful for your research of TAB2.
TAB1; MAP3K7; BECN1
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