Tert
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Official Full Name
Telomerase reverse transcriptase
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Overview
Telomerase is a ribonucleoprotein complex that replicates telomere ends by the addition of the Telomere repeat TTAGGG. Human Telomerase Reverse Transcriptase (hTERT) is one of the three core components of the enzyme-the catalytic subunit. Since male germ cells and the majority of human cancers have unlimited replicative capacity, they observe high levels of telomerase activity. hTERT is repressed in most somatic cells expect in proliferating progenitor cells and activated lymphocytes. In contrast, hTERT is activated in approximately 85% of human cancer tissues. Due to the biological function of hTERT, it has been seen as the most general of tumor markers known and has significant potential for diagnostics, prognostics, and therapeutics. -
Synonyms
DKCA2; DKCB4; EST2; PFBMFT1; TCS1; TP2; TRT; hEST2; hTRT; telomerase catalytic subunit; telomerase-associated protein 2;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- HEK293
- Mammalian Cell
- C
- His
- His (Fc)
- Avi
- His|GST
- His|SUMO
- N/A
- N
- GST
- Involved Pathway
- Protein Function
- Interacting Protein
- Tert Related Research Area
Tert involved in several pathways and played different roles in them. We selected most pathways Tert participated on our site, such as HTLV-I infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with Tert were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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HTLV-I infection | CD3D;KRAS;HLA-DRB3;PPP3R2;TP53;DVL3;VAC14;GPS2;HLA-DPB1 |
Tert has several biochemical functions, for example, DNA binding, RNA binding, RNA-directed DNA polymerase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Tert itself. We selected most functions Tert had, and list some proteins which have the same functions with Tert. You can find most of the proteins on our site.
Function | Related Protein |
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DNA binding | SMARCAD1;ZHX2;ZNF559-ZNF177;POU3F3;CMYB;SNAPC3;ZFP354B;ZBED2;RAD52 |
RNA binding | PHAX;SNRNP70;PSMA6;ALYREF;OASL2;RPL18;EIF4EA;KIN;C14orf166 |
RNA-directed DNA polymerase activity | |
contributes_to RNA-directed RNA polymerase activity | |
metal ion binding | COQ7;FUZ;SNAI2;KAT6A;KLF6;ZFP473;CCDC76;PVALB5;ZNF461 |
nucleotidyltransferase activity | UAP1L1;GDPGP1;PAPSS1;PAPSS2;POLN;MOCS3;POLE2;GKUP;PRIM2 |
protein binding | MRPS23;RFC3;MARCH5;COG7;SEPT3;IFNA2;Artn;EMP1;VAMP2 |
protein homodimerization activity | AGR2;MECOM;PDCD6IP;PLDN;TRPM8;NOS2;CREB3;TERT;STOM |
tRNA binding | XPO5;PSTK;EIF2A;AARSD1;TRMU;CTU2;AARS2;MADD;FARS2 |
telomerase RNA binding | TERT;HNRNPU;NOP10;NHP2;GAR1;HNRNPC;WRAP53;DKC1;PINX1 |
telomerase RNA reverse transcriptase activity | |
contributes_to telomerase RNA reverse transcriptase activity | |
telomerase activity | PRIM2;UAP1L1;PTGES3;TERT;CCDC111;DKC1;CTU1 |
telomeric DNA binding | TERFA;TERF1;TERT;TERF2;POT1A;OBFC1;PIF1;CDAN1;TINF2 |
transcription coactivator binding | PASD1;ZBTB49;TERT;NR4A3;RORA |
Tert has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Tert here. Most of them are supplied by our site. Hope this information will be useful for your research of Tert.
terc_human_rna; RUVBL1
- Q&As
- Reviews
Q&As (5)
Ask a questionYes, mutations in the TERT gene have been identified in certain genetic disorders. Understanding these mutations can be crucial for diagnosing and managing related conditions.
One challenge is the potential impact on normal, healthy cells, as they also rely on TERT for telomere maintenance. Specific targeting of cancer cells without affecting normal cells is a significant hurdle.
The ethical implications include concerns about unintended consequences, potential misuse, and ensuring equitable access to TERT-based therapies.
Research suggests that TERT expression levels may be indicative of treatment response. Patients with higher TERT expression might respond differently to certain therapies.
TERT's role in maintaining telomeres is linked to cellular aging. Exploring ways to modulate TERT expression could have implications for anti-aging interventions.
Customer Reviews (3)
Write a reviewThis existing knowledge base provides a solid foundation for designing experiments and interpreting results, ultimately enhancing the efficiency and reliability of trials involving TERT protein.
With their support, I can confidently explore the intricacies of TERT and make significant contributions to the understanding of its functions in various biological processes.
Extensive research has been conducted on TERT, making it relatively accessible and well-understood in terms of its structure and functions.
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