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TFAP2B

Official Full Name

transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
Overview

This gene encodes a member of the AP-2 family of transcription factors. AP-2 proteins form homo- or hetero-dimers with;other AP-2 family members and bind specific DNA sequences. They are thought to stimulate cell proliferation and;suppress terminal differentiation of specific cell types during embryonic development. Specific AP-2 family members;differ in their expression patterns and binding affinity for different promoters. This protein functions as both a;transcriptional activator and repressor. Mutations in this gene result in autosomal dominant Char syndrome, suggesting;that this gene functions in the differentiation of neural crest cell derivatives.
Synonyms

TFAP2B; transcription factor AP-2 beta (activating enhancer binding protein 2 beta); transcription factor AP 2 beta (activating enhancer binding protein 2 beta); transcription factor AP-2-beta; AP2 B; Activating enhancer binding protein 2 beta; AP 2B; AP2B; AP2beta; MGC21381; OTTHUMP00000039925; TFAP 2B; Transcription factor AP 2 beta; Transcription factor AP2 beta; AP2-beta; OTTHUMP00000016595; activating enhancer-binding protein 2-beta; AP-2B; AP2-B;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	TFAP2B-3193H	Recombinant Human TFAP2B, GST-tagged	E.coli	GST	C-term-350aa	$319 / 25ug
Human	TFAP2B-586H	Recombinant Human TFAP2B Protein, His-tagged	E.coli	His		Inquiry
Zebrafish	TFAP2B-2570Z	Recombinant Zebrafish TFAP2B	Mammalian Cell	His		Inquiry
Zebrafish	TFAP2B-3056Z	Recombinant Zebrafish TFAP2B	Mammalian Cell	His		Inquiry
Chicken	TFAP2B-6457C	Recombinant Chicken TFAP2B	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein

TFAP2B involved in several pathways and played different roles in them. We selected most pathways TFAP2B participated on our site, such as Neural Crest Differentiation, which may be useful for your reference. Also, other proteins which involved in the same pathway with TFAP2B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Neural Crest Differentiation	OLIG2;DMBX1;TXLNB;MBP;CTBP2;ZIC1;ASCL1;FOXD3;TFAP2A

TFAP2B has several biochemical functions, for example, DNA binding, RNA polymerase II core promoter sequence-specific DNA binding, RNA polymerase II transcription coactivator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TFAP2B itself. We selected most functions TFAP2B had, and list some proteins which have the same functions with TFAP2B. You can find most of the proteins on our site.

Function	Related Protein
DNA binding	ZBTB16;HOXB5B;ARHGEF38;EZH2;ZNF224;ZFP367;ZNF26;ZFP629;ORC1L
RNA polymerase II core promoter sequence-specific DNA binding	ZFPM1;NR4A2;STAT5A;MITF;TBR1;HOXB3;H2AFZ;SOX11;SP3
RNA polymerase II transcription coactivator activity	MED12L;MEF2A;ISL1;TFAP2B;HYAL2;PITX2;CITED4;PHF17;MKL1B
RNA polymerase II transcription corepressor activity	URI1;TBX15;SIN3AA;HDAC1;TLE1;RBBP8;HEYL;RERE;TCERG1
RNA polymerase II transcription factor activity, sequence-specific DNA binding	HIF1AB;ETS1;FOXH1;RUNX3;TP73;FOXN1;ZNF446;TFAP2A;EOMESA
cysteine-type endopeptidase inhibitor activity involved in apoptotic process	IGF1RA;VIL1;BIRC3;DPEP1;TFAP2B;PRDX3;SERPINB1A;RPS6KA1;TNFSF14
enhancer sequence-specific DNA binding	FOXN4;HMGB2;KLF6A;KLF7B;TBX19;GATA1;ISL1;GATA4;XBP1
protein binding	NCAPH;PBRM1;HILPDA;GRIN2C;GRIK3;GALNT2;CNOT6L;TIMP2;RFX4
protein dimerization activity	AHRRB;FAP;TFAP2C;ATOH7;NLGN1;MXD3;PIP4K2AA;NEUROG2;OLIG3
protein heterodimerization activity	TAL1;BHLHE40;H2AFX;TP53;ODZ4;ADD2;HSPD1;PDZD7;BCL11A
protein homodimerization activity	FGFR1;APOE;BMP4;DNM1L;UGT1A7;MLL1;CARS;GSTM1;ABCB9
sequence-specific DNA binding	TRP53;FOXD1;SIX9;HOXB13;PAX7;CREB5;POU1F1;ZFP110;NR6A1A
transcription coactivator activity	RNF20;ARID1A;NCOA4;COPS5;HSF2;TBPL1;LPIN3;RAN;TFDP1B
transcription corepressor activity	BHLHE40;SKOR1A;TLE4;TFAP2B;LHX1;SSX1;NFIL3;ARHGAP35;NR1H4
transcription factor activity, RNA polymerase II core promoter sequence-specific	PAX7;HEY1;NKX3;TFAP2B;SMAD3;MEF2C;HEY2;HEYL;MAX
transcription factor activity, sequence-specific DNA binding	PBX1;NKX2-5;HOXD3;TBX18;MTA3;KAT7B;PRDM1A;TCF25;NR1D4B
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding	EBF4;GLI2;NKX2-5;DDIT3;FOXK2;CAMTA2;SMAD4;FOXI1;SOX1

TFAP2B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TFAP2B here. Most of them are supplied by our site. Hope this information will be useful for your research of TFAP2B.

CITED2; UBE2I; HIST1H2AC; VPS11