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TIAM2

Official Full Name

T-cell lymphoma invasion and metastasis 2
Overview

This gene encodes a guanine nucleotide exchange factor. A highly similar mouse protein specifically activates ras-related C3 botulinum substrate 1, converting this Rho-like guanosine triphosphatase (GTPase) from a guanosine diphosphate-bound inactive state to a guanosine triphosphate-bound active state. The encoded protein may play a role in neural cell development. Alternatively spliced transcript variants encoding different isoforms have been described.
Synonyms

TIAM2; T-cell lymphoma invasion and metastasis 2; T-lymphoma invasion and metastasis-inducing protein 2; STEF; FLJ41865; SIF and TIAM1 like exchange factor; SIF and TIAM1-like exchange factor; T cell lymphoma invasion and metastasis 2; T lymphoma invasion and metastasis inducing protein 2; TIAM 2; TIAM-2; TIAM2_HUMAN; OTTHUMP00000017472; OTTHUMP00000231963; OTTHUMP00000231964; OTTHUMP00000231965; OTTHUMP00000231968; OTTHUMP00000238735; OTTHUMP00000238736;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse

Source

E.coli
HEK293
HEK293T
Mammalian Cell

Tag

His
His (Fc)
Avi
Myc
DDK
Myc|DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Price
Human	TIAM2-30624TH	Recombinant Human TIAM2, His-tagged	E.coli	His	Inquiry
Human	TIAM2-1780HCL	Recombinant Human TIAM2 cell lysate		N/A	Inquiry
Human	TIAM2-1048H	Recombinant Human TIAM2 Protein, MYC/DDK-tagged	HEK293	Myc/DDK	Inquiry
Human	TIAM2-517H	Recombinant Human TIAM2 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK	Inquiry
Mouse	TIAM2-16771M	Recombinant Mouse TIAM2 Protein	Mammalian Cell	His	Inquiry
Mouse	Tiam2-6425M	Recombinant Mouse Tiam2 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK	Inquiry
Mouse	TIAM2-9206M	Recombinant Mouse TIAM2 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	Inquiry
Mouse	TIAM2-9206M-B	Recombinant Mouse TIAM2 Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Chicken	TIAM2-4637C	Recombinant Chicken TIAM2	Mammalian Cell	His	Inquiry

Involved Pathway
Protein Function
Interacting Protein

TIAM2 involved in several pathways and played different roles in them. We selected most pathways TIAM2 participated on our site, such as Cell death signalling via NRAGE, NRIF and NADE, Fatty acid, triacylglycerol, and ketone body metabolism, G alpha (12/13) signalling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with TIAM2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Cell death signalling via NRAGE, NRIF and NADE	KALRNB;ITSN1;ARHGEF3;TRIO;ARHGEF9;KALRN;AKAP13;PLEKHG2;BCL2L11
Fatty acid, triacylglycerol, and ketone body metabolism	ACOT12;AGPAT2;MED15;G0S2;ANKRD1;ACOT6;AGT;MTF1;CYP7A1
G alpha (12/13) signalling events	FGD4;GNA13B;TRIO;DCLRE1B;AKAP13;ITSN1;ADRA1B;ADRA1D;KALRNB
GPCR downstream signaling	ARHGEF1A;AKAP13;CGA;OPN5;INSL3;CNR2;ITSN1;SSTR2;RGS12
Metabolism	CYP2K18;BRSK2;CYP26A1;AWAT1;ARSK;CHP;SPTLC1;UPP2;COX14
Metabolism of lipids and lipoproteins	MED22;GDF1;STARD5;CYP4B1;SACM1LB;HSD17B11;AKR1C4;MED6;CEPT1
NRAGE signals death through JNK	FGD4A;FGD2;ARHGEF17;PLEKHG2;ARHGEF1A;ECT2;ARHGEF3;NET1;TIAM2
PPARA activates gene expression	SREBF2;MED6;MED15;MED7;APOA5;MED18;G0S2;MED20;ANKRD1

TIAM2 has several biochemical functions, for example, GTPase activator activity, Rho guanyl-nucleotide exchange factor activity, guanyl-nucleotide exchange factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TIAM2 itself. We selected most functions TIAM2 had, and list some proteins which have the same functions with TIAM2. You can find most of the proteins on our site.

Function	Related Protein
GTPase activator activity	RGS9A;TBC1D3B;CHN1;ARHGDIG;AGFG1B;SMAP2;VPS9D1;ASAP2A;RGS21
Rho guanyl-nucleotide exchange factor activity	DOCK9;ARHGEF3L;DCLRE1B;FGD2;ARHGEF33;C9orf100;ARHGEF16;FGD;BCR
guanyl-nucleotide exchange factor activity	CHRM4;DOCK4B;RAPGEF1B;ARHGEF17;DENND5B;ITSN2A;DIS3;RIC8B;DOCK8
receptor signaling protein activity	FCGR1A;CD19;RAF1A;TYROBP;DOK5;ARF1;FCAR;FLRT2;KLK1B3

TIAM2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TIAM2 here. Most of them are supplied by our site. Hope this information will be useful for your research of TIAM2.

TK1; H2AFX; ANXA7; DNM2; UFD1L; SH3GL2