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TLE2

Official Full Name

transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila)
Overview

Transducin-like enhancer protein 2 is a protein that in humans is encoded by the TLE2 gene.
Synonyms

TLE2; transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila); transducin like enhancer of split 2, homolog of Drosophila E(sp1); transducin-like enhancer protein 2; enhancer of split groucho 2; ESG; ESG2; FLJ41188; GRG2; Enhancer of split groucho-like protein 2; Groucho2; KIAA4188; MGC124808; mKIAA4188; Tle2 protein; TLE2_HUMAN; transducin like enhancer of split 2; Transducin like enhancer protein 2; Transducin-like enhancer of split 2, homolog of Drosophila E(spl); transducin-like enhancer of split 2, homolog of Drosophila E(sp1);

Species	Cat.#	Product name	Source (Host)	Tag	Price
Human	TLE2-1050HCL	Recombinant Human TLE2 293 Cell Lysate	HEK293	N/A	Inquiry
Human	TLE2-1209H	Recombinant Human TLE2 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK	Inquiry
Mouse	Tle2-6448M	Recombinant Mouse Tle2 Protein, Myc/DDK-tagged	HEK293T	Myc/DDK	Inquiry
Zebrafish	TLE2-7087Z	Recombinant Zebrafish TLE2	Mammalian Cell	His	Inquiry

Involved Pathway
Protein Function
Interacting Protein

TLE2 involved in several pathways and played different roles in them. We selected most pathways TLE2 participated on our site, such as Deactivation of the beta-catenin transactivating complex, Degradation of beta-catenin by the destruction complex, Formation of the beta-catenin:TCF transactivating complex, which may be useful for your reference. Also, other proteins which involved in the same pathway with TLE2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Deactivation of the beta-catenin transactivating complex	SOX9B;BCL9L;PYGO2;SOX4B;CBY1;TLE1;PYGO1;SOX4A;ASH2L
Degradation of beta-catenin by the destruction complex	TLE3;CTBP1;AES;TLE3B;TLE1;CTBP2;FAM123B;TLE2;TLE4
Formation of the beta-catenin:TCF transactivating complex	PYGO2;TLE2;BCL9L;TLE1;BCL9;H3F3D;TLE3B;RBBP5;ASH2L
NOTCH1 Intracellular Domain Regulates Transcription	TLE3;TLE2;TLE1;HEY2;HEYL;HEY1;TLE4;TUBB3
Regulation of Wnt-mediated beta catenin signaling and target gene transcription	ZCCHC12;TCF4;KRT1;MYOG;TLE2;T;IGF2BP1;TNIK;CBY1
Repression of WNT target genes	TLE4;TLE3;AES;TLE3B;TLE2
Signal Transduction	DHRS3A;ARHGAP4;CNGA1;PPY;CD97;ARHGAP32;KIF14;FST;APOA4B.2
Signaling by NOTCH	MDKB;MDKA;RAB6A;HEYL;TLE3;DLK1;TLE2;DNER;TLE4

TLE2 has several biochemical functions, for example, protein binding, transcription corepressor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TLE2 itself. We selected most functions TLE2 had, and list some proteins which have the same functions with TLE2. You can find most of the proteins on our site.

Function	Related Protein
protein binding	HDGF2;ERBB4;SSX1;MLLT1;MUL1;HIP1R;DAB2;TTC37;CTSL1
transcription corepressor activity	NSD1;DMAP1;CBX4;NR0B1;LHX1A;SKI;CDYL;YAP1;NOC2L

TLE2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TLE2 here. Most of them are supplied by our site. Hope this information will be useful for your research of TLE2.

DDB1; NUDC; CUL4B