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TNPO1

Official Full Name

transportin 1
Overview

This gene encodes the beta subunit of the karyopherin receptor complex which interacts with nuclear localization signals to target nuclear proteins to the nucleus. The karyopherin receptor complex is a heterodimer of an alpha subunit which recognizes the nuclear localization signal and a beta subunit which docks the complex at nucleoporins. Alternate splicing of this gene results in two transcript variants encoding different proteins. [provided by RefSeq, Jul 2008]
Synonyms

TNPO1; transportin 1; MIP; TRN; IPO2; MIP1; KPNB2; transportin-1; importin 2; importin beta 2; importin beta-2; karyopherin beta-2; M9 region interaction protein; karyopherin (importin) beta 2;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Cattle
Human
Mouse

Source

E.coli
HEK293
Mammalian Cell
Wheat Germ

Tag

His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	TNPO1-31605TH	Recombinant Human TNPO1	Wheat Germ	N/A	117 amino acids	Inquiry
Human	TNPO1-342H	Recombinant Human TNPO1 Protein, His-tagged	E.coli	His	Lys626~Val836	Inquiry
Mouse	Tnpo1-343M	Recombinant Mouse Tnpo1 Protein, His-tagged	E.coli	His	Cys597~Ile837	Inquiry
Mouse	TNPO1-17203M	Recombinant Mouse TNPO1 Protein	Mammalian Cell	His		Inquiry
Mouse	TNPO1-9503M	Recombinant Mouse TNPO1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	TNPO1-9503M-B	Recombinant Mouse TNPO1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Cattle	TNPO1-341C	Recombinant Cattle TNPO1 Protein, His-tagged	E.coli	His	Pro593~Val836	Inquiry

Involved Pathway
Protein Function
Interacting Protein

TNPO1 involved in several pathways and played different roles in them. We selected most pathways TNPO1 participated on our site, such as Assembly of the primary cilium, Gene Expression, Intraflagellar transport, which may be useful for your reference. Also, other proteins which involved in the same pathway with TNPO1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Assembly of the primary cilium	EXOC3;NEDD1;AKAP9;MAPRE1A;SSTR3;IFT20;CENPJ;UNC119.1;BBS10
Gene Expression	ZFP2;ZNF566;NR1I2;ZNF143A;ZNF74;ZNF75A;NRBF2B;ZNF710;ADAT1
Intraflagellar transport	IFT88;WDR34;KIFAP3A;KIF17;HSPB11;IFT-20;WDR19;TRIP11;TCTEX1D1
Organelle biogenesis and maintenance	BBS2;RAB3IP;BBS5;POLG2;BBS7;PTCD3;MTIF3;PKD2;MRPS34
Regulation of mRNA stability by proteins that bind AU-rich elements	HNRNPD;SET;KHSRP;ZFP36L1B;ELAVL1;HUG;SETB;SETA;ZFP36L1
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA

TNPO1 has several biochemical functions, for example, Ran GTPase binding, nuclear localization sequence binding, poly(A) RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TNPO1 itself. We selected most functions TNPO1 had, and list some proteins which have the same functions with TNPO1. You can find most of the proteins on our site.

Function	Related Protein
Ran GTPase binding	XPOT;XPO4;XPO6;RANGRF;IPO7;NXT1;TNPO2;IPO5;IPO13
nuclear localization sequence binding	IPO5;KPNA5;NUP214;KPNA2;KPNA1;IPO4;BRAP;TNPO3;NFKBIA
poly(A) RNA binding	RPS19;ZCCHC24;CROP;LBR;SF3A1;DMGDH;TRMT10C;RPS27A;SRP14
protein binding	RSPH3;PPP1R3C;UPF3B;POGZ;GP5;DNPEP;F11;ARL6IP5;GAB2
protein transporter activity	COX18;TIMM9;COG3;KPNA4;IPO5;PPIAL4A;KPNB1;USO1;AP4B1

TNPO1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TNPO1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TNPO1.

RAN; NXF1; LRRK2; L1; L2; E6; L1; L1; ACTB; GRB2; YWHAZ; glsA2; 1-phosphatidyl-1d-myo-inositol 3,5-bisphosphate; 1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate; 15-deoxy-delta(12,14; midostaurin