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TOPORS

Official Full Name

topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase
Overview

This gene encodes a nuclear protein which is serine and arginine rich, and contains a RING-type zinc finger domain. It is highly expressed in the testis, and functions as an ubiquitin-protein E3 ligase. Mutations in this gene are associated with retinitis pigmentosa type 31. Alternatively spliced transcript variants, encoding different isoforms, have been observed for this locus.
Synonyms

TOPORS; topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase; retinitis pigmentosa 31 (autosomal dominant) , RP31, topoisomerase I binding, arginine/serine rich; E3 ubiquitin-protein ligase Topors; LUN; TP53BPL; SUMO1-protein E3 lig;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	TOPORS-3354H	Recombinant Human TOPORS, His-tagged	E.coli	His	1-332aa	$319 / 25ug
Rhesus Macaque	TOPORS-4903R	Recombinant Rhesus monkey TOPORS Protein, His-tagged	Mammalian Cell	His		Inquiry
Rhesus Macaque	TOPORS-4717R	Recombinant Rhesus Macaque TOPORS Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rhesus Macaque	TOPORS-4717R-B	Recombinant Rhesus Macaque TOPORS Protein Pre-coupled Magnetic Beads	HEK293			Inquiry

Involved Pathway
Protein Function
Interacting Protein

TOPORS involved in several pathways and played different roles in them. We selected most pathways TOPORS participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with TOPORS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

TOPORS has several biochemical functions, for example, DNA binding, DNA topoisomerase binding, SUMO transferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TOPORS itself. We selected most functions TOPORS had, and list some proteins which have the same functions with TOPORS. You can find most of the proteins on our site.

Function	Related Protein
DNA binding	FOXF2;TBL1XR1;RFXANK;ENG1B;RFX5;INSM1B;CDKN2A;SNAPC4;TBL1Y
DNA topoisomerase binding	SETMAR;TOPORS
SUMO transferase activity	TOPORS;PIAS4;SUMO1;UBE2IA;SUMO4;UBE2IB;CBX4;SUMO3;NSMCE2
antigen binding	TSPAN4;PPP2R1A;FCN3;LILRA2;HNRNPM;IGJ;IGKC;LILRB4;IGLL1
ligase activity	PELI3;TRIM4;MEX3C;BIRC2;UHRF2;TRIM37;MARCH5L;CDC34B;RNF212
protein binding	C17orf81;RAB27A;GPR37L1;ADAM8;ESR1;ZEB1;FAM192A;SSU72;ERG
ubiquitin protein ligase activity	RNF2;UBE2NB;RABGEF1;MDM2;PPIL2;HECTD2;RAD18;NEDD4L;TRIM37
ubiquitin-protein transferase activity	TRIM69;BIRC7;IRAK1;UBE2D4;FBXL5;ZNRF3;FBXL14B;FBXO7;RNF146
zinc ion binding	RBM14A;BMI1A;ADAMTS18;ZNF598;ADAM28;CA8;ADAM23;PRKCA;LMO4

TOPORS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TOPORS here. Most of them are supplied by our site. Hope this information will be useful for your research of TOPORS.

TP53; CASP8; Rep78; UBE2L6; Tp53; Rep68; UBE2D1; UBE2D3; UBE2N; UBE2D2; SATB1; SETX; SNIP1; pyrC; UBE2W; UBE2D4; UBE2J1