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UGT1A3

Official Full Name

UDP glucuronosyltransferase 1 family, polypeptide A3
Overview

This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5 exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. Substrates of this enzyme include estrone, 2-hydroxyestrone, and metabolites of benzo alpha-pyrene.
Synonyms

UGT1A3; UDP glucuronosyltransferase 1 family, polypeptide A3; UDP glycosyltransferase 1 family, polypeptide A3; UDP-glucuronosyltransferase 1-3; UGT1C; EC 2.4.1.17; GNT 1; GNT1; UDP glucuronosyltransferase 1 3; UDP glucuronosyltransferase 1 family polypeptide A3; UDP glucuronosyltransferase 1A3; UDP glucuronosyltransferase; UDP glycosyltransferase 1 family polypeptide A3; UDPGT; UGT 1; UGT 1C; UGT1; UGT1 03; UGT1*3; UGT1.3; OTTHUMP00000065193; UDP-glucuronosyltransferase 1-C; UDP-glucuronosyltransferase 1A3; UGT-1C; UGT1-03; UDPGT 1-3;

Type

Recombinant Proteins

Species

Homo sapiens (Human)
Human
Rattus norvegicus (Rat)

Source

E.coli expression system
HEK293
HEK293T
In Vitro Cell Free System
Insect cells
Wheat Germ

Tag

His
Myc
DDK
Myc|DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	UGT1A3-207H	Recombinant Human UGT1A3	Wheat Germ	N/A		Inquiry
Human	UGT1A3-512H	Recombinant Human UGT1A3 Protein, MYC/DDK-tagged	HEK293	Myc/DDK		Inquiry
Human	UGT1A3-98H	Active Recombinant Human UGT1A3 Protein	Insect cells			Inquiry
Human	UGT1A3-3375H	Recombinant Human UGT1A3 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK		Inquiry
Human	UGT1A3-539HF	Recombinant Full Length Human UGT1A3 Protein	In Vitro Cell Free System		534 amino acids	Inquiry
Homo sapiens (Human)	RFL8549HF	Recombinant Full Length Human Udp-Glucuronosyltransferase 1-3(Ugt1A3) Protein, His-Tagged	E.coli expression system	His	Full Length of Mature Protein (29-534)	Inquiry
Rattus norvegicus (Rat)	RFL8576RF	Recombinant Full Length Rat Udp-Glucuronosyltransferase 1-3(Ugt1) Protein, His-Tagged	E.coli expression system	His	Full Length of Mature Protein (26-531)	Inquiry

Involved Pathway
Protein Function
Interacting Protein
UGT1A3 Related Articles

UGT1A3 involved in several pathways and played different roles in them. We selected most pathways UGT1A3 participated on our site, such as Pentose and glucuronate interconversions, Ascorbate and aldarate metabolism, Steroid hormone biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with UGT1A3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Pentose and glucuronate interconversions	UGT1A2;ALDH2.2;XYLB;UGT5G1;UGT1A3;ALDH3A2A;DCXR;KL;AKR1B10
Ascorbate and aldarate metabolism	ALDH2.2;UGT1A3;ALDH9A1A.1;UGT1A6A;UGT1A7C;UGT1A9;UGT1A6;ALDH9A1B;ALDH2.1
Steroid hormone biosynthesis	CYP3A7;COMTA;HSD17B8;CYP2C55;CYP2C37;CYP2C39;UGT1A9;CYP2C54;PPP1R2
Starch and sucrose metabolism	SI;ENPP1;GYS1;Amy1;AMY2A;UGT1A9;UGT1AB;HK2;UGP2
Retinol metabolism	CYP3A41A;RETSATL;CYP2C38;DGAT1;UGT2B7;ALDH1A2;RDH8;CYP2A12;UGT2A2
Porphyrin and chlorophyll metabolism	HMOX1A;UGT1A7C;GUSB;UGT1A1;HMOX2A;COX15;HCCSB;UGT1A6;UGT1A6A
Metabolism of xenobiotics by cytochrome P	ALDH3B1;UGT1A1;MGST1;ALDH1A3;CBR1;CBR1L;GSTT1;GSTM7;AKR7A2
Drug metabolism - cytochrome P	UGT2A3;UGT2A2;FMO1;GSTA3;GSTM6;AOX3;GSTA2;GSTM;GSTA1
Drug metabolism - other enzymes	ITPA;UGT1A6;NAT1;UGT1A1;GUSB;UGT1AB;UPP2;UCK2;UMPS
Metabolic pathways	DPYD;UQCRC2B;PTDSS2;PYGMA;TPI1A;KMO;MTHFD1L;MAN2A2;NADSYN1
Chemical carcinogenesis	GSTP2;ALDH3B2;CYP2C19;GSTM7;GSTA4;ADH2-2;SULT2A1;UGT2A3;CYP2A6

UGT1A3 has several biochemical functions, for example, enzyme binding, glucuronosyltransferase activity, NOT glucuronosyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by UGT1A3 itself. We selected most functions UGT1A3 had, and list some proteins which have the same functions with UGT1A3. You can find most of the proteins on our site.

Function	Related Protein
enzyme binding	DVL1;NOXA1;TGFB1;HIST1H2AG;TAL1;CAV1;PLCB1;ZFHX3;PEX7
glucuronosyltransferase activity	UGT1A3;UGT5D1;UGT2A3;UGT5E1;UGT1B1;UGT1B5;UGT2B3;CSGALNACT1;UGT2A5
NOT glucuronosyltransferase activity	UGT1A1;UGT1A4;UGT1A6;UGT1A3;UGT1A9;UGT1A7
protein heterodimerization activity	ITGB1A;TAF13;CLNS1A;HIST1H47;SCUBE1;ZHX3;BNIP3L;CEBPB;OSTB
protein homodimerization activity	AXIN1;ACVR1;P2RX4;GDNF;ZFP652;TARBP2;DHDPSL;MAP3K9;MITD1
retinoic acid binding	CRABP2B;PTGDSB;CRABP2;CYP26B1;CRABP2A;CRABP1;NR2F2;LRAT;LCN12

UGT1A3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UGT1A3 here. Most of them are supplied by our site. Hope this information will be useful for your research of UGT1A3.

Lee, SJ; Park, JB; et al. In vitro selective inhibition of human UDP-glucuronosyltransferase (UGT) 1A4 by finasteride, and prediction of in vivo drug-drug interactions. TOXICOLOGY LETTERS 232:458-465(2015).

Tian, XG; Liang, SC; et al. Regioselective Glucuronidation of Andrographolide and Its Major Derivatives: Metabolite Identification, Isozyme Contribution, and Species Differences. AAPS JOURNAL 17:156-166(2015).