VCP
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Official Full Name
valosin containing protein
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Overview
Valosin-containing protein (VCP) is a highly conserved and abundant 97 kDa protein that belongs to the AAA (ATPase associated with a variety of cellular activities) family of proteins. VCP assembles as a homo-hexamer, forming a ring with a channel at its -
Synonyms
VCP; valosin containing protein; transitional endoplasmic reticulum ATPase; IBMPFD; p97; TER ATPase; yeast Cdc48p homolog; valosin-containing protein; 15S Mg(2+)-ATPase p97 subunit; TERA; ALS14; MGC8560; MGC131997; MGC148092;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- Zebrafish
- E.coli
- HEK293
- HEK293T
- Insect cell
- Mamanlian cells
- Mammalian Cell
- Flag
- GST
- His
- His (Fc)
- Avi
- His|T7
- Myc
- DDK
- Myc|DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- VCP Related Articles
- VCP Related Research Area
VCP involved in several pathways and played different roles in them. We selected most pathways VCP participated on our site, such as Protein processing in endoplasmic reticulum, Legionellosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with VCP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Protein processing in endoplasmic reticulum | HSPA1A;SEL1L2;ATXN3L;LMAN2;SAR1A;TRAM1;UBQLN4;NGLY1;ERO1LB |
Legionellosis | HSPA1A;VCP;SAR1B;NLRC4;IL6;IL12A;TNF;HSF1;C3 |
VCP has several biochemical functions, for example, ADP binding, ATP binding, ATPase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by VCP itself. We selected most functions VCP had, and list some proteins which have the same functions with VCP. You can find most of the proteins on our site.
Function | Related Protein |
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ADP binding | P2RY1;LONP1;ABCG1;MIEF1;PRKAG2;CYB5R3;ERN1;MYO6;ATP1A1 |
ATP binding | CDKL1;SMOK2B;FES;TSSK1;PAPSS2B;KIFC2;STK38A;GLULC;PRKACBB |
ATPase activity | ATAD1A;KIF15;KIF2A;ABCG2A;ENTPD2;EIF4A1B;CLPB;KIF2C;KIF6 |
BAT3 complex binding | VCP;USP13;AMFR;SGTA |
K48-linked polyubiquitin binding | UFD1L;IKBKE;UBXN1;VCP |
MHC class I protein binding | VCP;ATP5B;PILRB;TUBB4B;TAP1;CD244;PILRB2;CD8B;HLA-E |
deubiquitinase activator activity | |
identical protein binding | ALAD;C1QTNF2;NFKB1;PPP1R13L;DES;GOT1;PRPF19;ETNPPL;BNIP2 |
lipid binding | PRAM1;ESYT3;C3;HDLBP;FAM125A;FFAR1;FAM123B;CPTP;FABP10A |
poly(A) RNA binding | TCP1;NOL7;RPL27A;DHX34;RBMX2;MSI1;NHP2L1;DDX42;NUPL2 |
polyubiquitin binding | RAD23B;UBQLN4;BRCC3;PSMD4;AGL;DNAJB2;PSMD4B;BAG6;FAM175B |
protein binding | LC3;WNT11;FAM158A;C6orf108;GRN;GFER;USP44;FAM115A;CASP9 |
protein domain specific binding | HIST1H4H;CTBP1;HIST2H4A;TACC2;MTOR;IL1B;RCC2;NFE2L2;STX18 |
protein phosphatase binding | DLG4;IRS2;TRP53;VRK3;HSF4;RPA3;PARD3;ANAPC4;STAT6 |
ubiquitin protein ligase binding | STUB1;MOAP1;BAG5;GABARAPL1;PTPN22;PIAS1;MYOD1;PER3;CCT2 |
ubiquitin-like protein ligase binding | VCP;TRIP4;CDK5RAP3;USP13;CEBPB;DDRGK1 |
ubiquitin-specific protease binding | AMFR;BAG6;VCP;MARCH6;SELS;PARK7;PARK2;VPS24;SART3 |
VCP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with VCP here. Most of them are supplied by our site. Hope this information will be useful for your research of VCP.
ATXN3; NSFL1C; UBXN6
- Q&As
- Reviews
Q&As (5)
Ask a questionYes, genetic testing can identify mutations in the VCP gene, aiding in the diagnosis of VCP-related disorders.
Currently, VCP protein levels are not widely used as a diagnostic marker, but ongoing research may reveal its potential utility in the future.
The potential therapeutic targeting of VCP is an area of active research, with efforts to develop drugs that modulate its activity for the treatment of specific diseases.
Yes, alterations in VCP function may contribute to various health conditions, including autoimmune diseases and metabolic disorders.
VCP plays a crucial role in eliminating misfolded or damaged proteins, contributing to cellular protein quality control mechanisms.
Customer Reviews (3)
Write a reviewThis can involve organizing conferences, workshops, and webinars to discuss the latest advancements, share research findings, and broaden the understanding of VCP function.
Researchers have successfully utilized VCP protein in electron microscopy studies, unraveling crucial insights into protein interactions and conformational changes.
The exceptional performance of VCP protein in both ELISA and protein electron microscopy structure analysis positions it as a valuable tool in a broad range of research applications.
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