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VPRBP

Official Full Name

Vpr (HIV-1) binding protein
Overview

VprBP may act as a receptor for CUL4-DDB1 ubiquitin ligase complex. In case of HIV1 infection, this protein is recruited by HIV1 VPR protein which is believed to result in an arrest of the cell cyccle in the G2 phase.
Synonyms

VPRBP; Vpr (HIV-1) binding protein; DCAF1; protein VPRBP; Vpr-binding protein; vpr-interacting protein; HIV-1 Vpr-binding protein; DDB1 and CUL4 associated factor 1; DDB1- and CUL4-associated factor 1; serine/threonine-protein kinase VPRBP;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	VPRBP-1088H	Recombinant Human VPRBP protein, His-tagged	E.coli	His	1045-1396aa	Inquiry
Mouse	VPRBP-18354M	Recombinant Mouse VPRBP Protein	Mammalian Cell	His		Inquiry
Mouse	VPRBP-10055M	Recombinant Mouse VPRBP Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	VPRBP-10055M-B	Recombinant Mouse VPRBP Protein Pre-coupled Magnetic Beads	HEK293			Inquiry

Involved Pathway
Protein Function
Interacting Protein

VPRBP involved in several pathways and played different roles in them. We selected most pathways VPRBP participated on our site, such as Adaptive Immune System, Antigen processing: Ubiquitination &amp, Proteasome degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with VPRBP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Adaptive Immune System	EVL;AP1S1;NRG4;ARF1;PJA2;ASB6;RNF4;ASB9;GRAP2B
Antigen processing: Ubiquitination &amp	RNF25;UBE2U;UBE2J2;ASB14;UBE2V1;TRAF7;RNF111;FBXO17;BLMH
Proteasome degradation	LRSAM1;ASB11;ASB14;LRRC41;PJA1;ASB8;UBR1;TRIM11;RNF144B
Class I MHC mediated antigen processing &amp	LTN1;ATG7;FBXO17;TRIM41;KLHL21;ASB11;TRAF7;UBE2E3;UBA5
presentation	ARIH2;ASB8;B2ML;UBE2J2;TRAF7;ASB11;WSB1;HUWE1;SPSB1
Immune System	MKRN1;LTF;ASB8;EDA;BTR16;KLRF1;AP1G1;RBCK1;ATG7
mRNA processing	RBM39;CELF2;HNRNPL;HNRNPD;PRPF4B;EIF4E3;CLK3;DDX20;PRPF4BB

VPRBP has several biochemical functions, for example, ATP binding, histone kinase activity (H2A-T120 specific), kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by VPRBP itself. We selected most functions VPRBP had, and list some proteins which have the same functions with VPRBP. You can find most of the proteins on our site.

Function	Related Protein
ATP binding	CDKL3;DDX20;Fert2;GUCY2F;P2RX1;NME7;P2RX3B;NPR1;AKT3A
histone kinase activity (H2A-T120 specific)
kinase activity	CKMB;PIK3R3B;PRKCBP1L;GRK1A;CDK14;CCL3;PRKACBA;BMPR1BA;ALPK2
nucleotide binding	PRKACAA;RIPK4;TRIOA;SMG1;SRSF1B;SRSF1;MAPK14A;RAB12;GLULA
protein serine/threonine kinase activity	MAPKAPK2;CAMK1DA;LRRK2;HIPK3;IRAK4;CSNK2A1;CASK;AKT2;ULK3
transferase activity	CSNK1G2B;NME2A;PRKCDA;CKMT2A;PLAUB;PFKFB2A;ROCK2A;UAP1L1;UGT5B2

VPRBP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with VPRBP here. Most of them are supplied by our site. Hope this information will be useful for your research of VPRBP.

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