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WIPI1

Official Full Name

WD repeat domain, phosphoinositide interacting 1
Overview

WD40 repeat proteins are key components of many essential biologic functions. They regulate the assembly of;multiprotein complexes by presenting a beta-propeller platform for simultaneous and reversible protein-protein;interactions. Members of the WIPI subfamily of WD40 repeat proteins, such as WIPI1, have a 7-bladed propeller;structure and contain a conserved motif for interaction with phospholipids (Proikas-Cezanne et al., 2004 (PubMed;15602573)).
Synonyms

WIPI1; WD repeat domain, phosphoinositide interacting 1; WD repeat domain phosphoinositide-interacting protein 1; Atg18; ATG18A; FLJ10055; WIPI49; ATG 18; Atg18 protein homolog; WD repeat domain phosphoinositide interacting 1; WD repeat domain phosphoinositide interacting protein 1; WD40 repeat protein interacting with phosphoinositides of 49 kDa; WD40 repeat protein interacting with phosphoInositides of 49kDa; WIPI 1 alpha; WIPI 1; WIPI 49; WIPI 49 kDa; WIPI-1; WIPI1_HUMAN; WIPI-1 alpha;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	WIPI1-3733H	Recombinant Human WIPI1, GST-tagged	E.coli	GST	346-446aa	$319 / 25ug
Human	WIPI1-310HCL	Recombinant Human WIPI1 293 Cell Lysate	HEK293	N/A		Inquiry
Zebrafish	WIPI1-10706Z	Recombinant Zebrafish WIPI1	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein

WIPI1 involved in several pathways and played different roles in them. We selected most pathways WIPI1 participated on our site, such as Cellular responses to stress, IRE1alpha activates chaperones, Macroautophagy, which may be useful for your reference. Also, other proteins which involved in the same pathway with WIPI1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Cellular responses to stress	PHC1;EHMT2;BMI1B;IGFBP7;RING1;ACD;AGO1;HIF1AL;C11orf73
IRE1alpha activates chaperones	SEC61B;DDX11;YIF1A;CTDSP2;PREB;C19orf10;TPP1;FKBP14;CXXC1
Macroautophagy	ATG9A;ATG4A;WIPI1;ATG101;LC3;WIPI2;AMBRA1;AMBRA1B;GABARAPL2
Metabolism of proteins	NAPG;DPH2;SLC34A2A;SFTPB;TOMM20;CNIH3;YKT6;LDHD;MPDU1A
Unfolded Protein Response (UPR)	SEC63;YIF1A;PDIA6;SERP1;WIPI1;YY2;KLHDC3;CXXC1;HDGF
XBP1(S) activates chaperone genes	PDIA6;KLHDC3;YIF1A;HYOU1;KDELR3;ASNA1;WIPI1;SERP1;DNAJB9

WIPI1 has several biochemical functions, for example, androgen receptor binding, estrogen receptor binding, phosphatidylinositol-3,5-bisphosphate binding. Some of the functions are cooperated with other proteins, some of the functions could acted by WIPI1 itself. We selected most functions WIPI1 had, and list some proteins which have the same functions with WIPI1. You can find most of the proteins on our site.

Function	Related Protein
androgen receptor binding	PRMT2;TRIM68;CCNE1;FOXH1;RB1;TCF21;KAT5;PRKCB;DAXX
estrogen receptor binding	TMEM38A;DDX17;CTNNB1;PPID;TRIP4;CNOT1;DDX54;WIPI1;TAF10
phosphatidylinositol-3,5-bisphosphate binding	MAPKAP1;CLVS1;SH3PXD2B;SESTD1;WDR45L;JPH2;PHLDA3;D6WSU116E;RAG2
phosphatidylinositol-3-phosphate binding	PARD3;ZFYVE26;SNX3;SNX24;SH3PXD2B;NCF4;WDR45;FAM21C;SNX20
receptor binding	Ren1;PVRL2L;STOML2;TESPA1;F2RL1;PCSK1N;HAO1;FGF11A;GLA

WIPI1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with WIPI1 here. Most of them are supplied by our site. Hope this information will be useful for your research of WIPI1.

pi3p; LGALS7B; PKP1; ATG2A; PPA1; KCTD15; BECN1; ATG12