T cell Activation Beads
Cat.No. : | T-3014M |
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Species : | Human |
Beads Size : | 1mL |
Capacity : | Up to 2×10^8 T cells |
Formulation : | Biodegradable matrix-coated nanoparticles conjugated with anti-CD3 and anti-CD28 antibodies supplied in phosphate buffered-saline (PBS), containing Human Serum Albumin (HSA), pH 7.0 - 7.4. |
Background : | The T cell Activation reagent induces T cell activation and expansion in enriched T cells or PBMCs. The T cell Activation reagent is composed of biodegradable matrix-coated nanoparticles conjugated with mouse anti-human CD3 and mouse anti-human CD28 antibodies. The small sized particulate structure of the activation reagent enables its easy removal by media washing or centrifugation. The recommended titer of 1:200 has been found to achieve efficient stimulation of majority of T cell subsets. For special applications, the optimal stimulation titer should be determined experimentally. Excessive amount of the T cell Activation reagent may result in over-activation of T cells risking activation-induced cell death. During cell expansion using the T cell Activation reagent, the cells take up to 13 days after reagent application to show optimal expansion. Restimulation after 13 days can be performed for longer cultivation. The T cell Activation reagent can be used together with cytokines such as human IL-2, IL-15, and IL-7 for more efficient activation. |
Application : | T cell Activation reagent has been developed for in vitro activation and expansion of enriched T cell populations or cells from hematological cell populations (e.g. PBMCs). |
Storage : | Store at 2-8 °C. Do not freeze. |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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