XCR1 Antibody-coupled magnetic MicroBeads
Cat.No. : | XCR1-5002M |
- Specification
- Gene Information
- Related Products
Species : | Mouse |
Capacity : | for 2×10^9 total cells |
Background : | Cross-presenting CD8+ conventional dendritic cells (cDCs) play a pivotal role in the induction of protective cytotoxic T lymphocyte (CTL) responses that are vital for the eradication of cancer and viral infections. In the past, studies of CD8+ cDCs have been hampered by their scarcity and the lack of specific cell surface markers. Therefore, methods for the detection and isolation of these cells were commonly based on a multitude of immunophenotypic criteria, including the expression of CD11c and CD8 and the absence of CD3, CD4, SIRP-α, and CD11b. Recently, it was demonstrated that cross-presenting cDCs in lymphoid and non-lymphoid tissues specifically express the two receptors Clec9-α and XCR1. The expression of the latter has been correlated with the ability to take up and cross-present exogenous antigens. |
Application : | Cross-presenting dendritic cells isolated with Anti-XCR1 MicroBead Kit (Spleen) can be used for antigen uptake and antigen processing assays, T cell activation or T cell tolerance induction, cross-priming of cytotoxic T cells, or T helper cell polarization. |
Products Types
◆ Recombinant Protein | ||
Xcr1-585M | Recombinant Mouse Xcr1 protein, His-tagged | +Inquiry |
XCR1-3497C | Recombinant Chicken XCR1 | +Inquiry |
◆ Lysates | ||
XCR1-266HCL | Recombinant Human XCR1 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
0
Inquiry Basket