Recombinant Canine IL6 protein, His-tagged

• Cat.No.: IL6-144C
• Product Overview: Recombinant Canine IL6(21-207aa) fused with His tag at C-terminal was expressed in Insect cells.

Specification

• Description: IL6, as known as Interleukin-6, is a phosphorylated and variably glycosylated cytokine. It is secreted by T cells and macrophages to stimulate immune response during infection and after trauma, especially burns or other tissue damage leading to inflammation. Also, this protein can function as an anti-inflammatory molecule, as in skeletal muscle where it is secreted in response to exercise.
• Source: Insect cells
• Species: Canine
• Tag: His
• Form: Liquid. In Phosphate Buffered Saline (pH 7.4) containing 10% glycerol.
• Molecular Mass: 22.0kDa (195aa)
  18-28kDa (SDS-PAGE under reducing conditions.)
• AA Sequence: FPTPGPLAGD SKDDATSNSL PLTSANKVEE LIKYILGKIS ALRKEMCDKF NKCEDSKEAL AENNLHLPKL EGKDGCFQSG FNQETCLTRI TTGLVEFQLH LNILQNNYEG DKENVKSVHM STKILVQMLK SKVKNQDEVT TPDPTTDASL QAILQSQDEC VKHTTIHLIL RSLEDFLQFS
  LRAVRIMLEH HHHHH
• Endotoxin: < 1.0 EU per 1 microgram of protein (determined by LAL method)
• Purity: > 95% by SDS - PAGE
• Applications: SDS-PAGE
• Storage: Can be stored at +4 centigrade short term (1-2 weeks). For long term storage, aliquot and store at -20 centigrade or -70 centigrade. Avoid repeated freezing and thawing cycles.
• Concentration: 0.5mg/ml (determined by Bradford assay)

Gene Information

• Gene Name: IL6 interleukin 6 [ Canis lupus familiaris ]
• Official Symbol: IL6
• Synonyms: IL-6; interleukin-6; interleukin 6 (interferon, beta 2)
• Gene ID: 403985
• mRNA Refseq: NM_001003301
• Protein Refseq: NP_001003301
• UniProt ID: P41323
• Chromosome Location: IL-6
• Pathway: AGE-RAGE signaling pathway in diabetic complications, organism-specific biosystem; Antifolate resistance, organism-specific biosystem; Cytokine Signaling in Immune system, organism-specific biosystem
• Function: cytokine activity; interleukin-6 receptor binding; growth factor activity